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  • Hindawi Limited  (11)
  • Tang, Jie  (11)
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  • Hindawi Limited  (11)
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  • 1
    Online Resource
    Online Resource
    Up-Regulation of RACGAP1 Promotes Progressions of Hepatocellular Carcinoma Regulated by GABPA via PI3K/AKT Pathway
    Hindawi Limited ; 2022
    In:  Oxidative Medicine and Cellular Longevity Vol. 2022 ( 2022-8-2), p. 1-16
    Details
    In: Oxidative Medicine and Cellular Longevity, Hindawi Limited, Vol. 2022 ( 2022-8-2), p. 1-16
    Abstract: Hepatocellular carcinoma (HCC) is one of the dominating tumors causing death due to lack of timely discovery and valid treatment. Abnormal increase of Rac GTPase activating protein 1 (RACGAP1) has been verified to be an oncogene in plenty tumors. The profound mechanism of RACGAP1 was rarely reported in HCC. In this study, we explored the function and mechanism of RACGAP1 in HCC through multiple analysis and experiments. RACGAP1 expression was up-regulated in HCC samples and the high expression of RACGAP1 was an independent prognostic risk factor for HCC patients. Meanwhile, RACGAP1 promoted developments of HCC both in vitro and in vivo. We verified that RACGAP1 promoted proliferation of HCC via PI3K/AKT/CDK2 and PI3K/AKT/GSK3β/Cyclin D1 signaling pathway. RACGAP1 accelerated the invasion and metastasis of HCC via phosphorylation of GSK3β and nuclear translocation of β-catenin. Furthermore, by luciferase reporter assay and Chromatin immunoprecipitation (ChIP) assay, we confirmed Recombinant GA Binding Protein Transcription Factor Alpha (GABPA) regulated the transcription of RACGAP1. All these findings revealed that RACGAP1 promotes the progression of HCC through a novel mechanism, which might be a new therapeutic target for HCC patients.
    Type of Medium: Online Resource
    ISSN: 1942-0994 , 1942-0900
    URL: Article
    DOI: 10.1155/2022/3034150
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2022
    detail.hit.zdb_id: 2455981-7
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  • 2
    Online Resource
    Online Resource
    Dissolvable Trimolybdate Nanowires as Ag Carriers for High-Efficiency Antimicrobial Applications
    Hindawi Limited ; 2012
    In:  ISRN Nanotechnology Vol. 2012 ( 2012-02-15), p. 1-8
    Details
    In: ISRN Nanotechnology, Hindawi Limited, Vol. 2012 ( 2012-02-15), p. 1-8
    Abstract: Elimination of bacteria and other microbes effectively is important to our daily life and a variety of medical applications. Here, we introduce a new kind of trimolybdate nanowires, namely Ag 2 − x ( NH 4 ) x Mo 3 O 10 ⋅ 3 H 2 O , that carry a large amount of Ag atoms in the lattice and Ag-rich nanoparticles on the surface. These nanowires can eliminate bacteria of E. coli , Staphylococcus aureus , and unknown microbes in raw natural water with high efficiency. For example, they can inactivate more than 98% of E. coli with a nanowire concentration of only 5 ppm in the solution. The excellent sterilization performance is attributed to the combined effects of Ag ions, Mo ions, and Ag-rich nanoparticles of the Ag 2 − x ( NH 4 ) x Mo 3 O 10 ⋅ 3 H 2 O nanowires. These nanowires are not dissolvable in deionized water but can be dissolved by the metabolic materials released from bacteria, making them attractive for many biological applications.
    Type of Medium: Online Resource
    ISSN: 2090-6072
    URL: Article
    DOI: 10.5402/2012/539601
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2012
    detail.hit.zdb_id: 2649182-5
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  • 3
    Online Resource
    Online Resource
    Specific Influences of Early Acoustic Environments on Cochlear Hair Cells in Postnatal Mice
    Hindawi Limited ; 2018
    In:  Neural Plasticity Vol. 2018 ( 2018), p. 1-13
    Details
    In: Neural Plasticity, Hindawi Limited, Vol. 2018 ( 2018), p. 1-13
    Abstract: The auditory function develops and matures after birth in many mammalian species. After hearing onset, environmental sounds exert profound and long-term effects on auditory functions. However, the effects of the acoustic environment on the functional development of the peripheral auditory system, especially the cochlear sensory hair cells, are still unclear. In the present study, we exposed mouse pups to frequency-enriched acoustic environments in postnatal days 0–14. The results indicated that the acoustic environment significantly decreased the threshold of the auditory brainstem response in a frequency-specific manner. Compared with controls, no difference was found in the number and alignment of inner and outer hair cells or in the length of hair bundles after acoustic overstimulation. The expression and function of prestin, the motor protein of outer hair cells (OHCs), were specifically increased in OHCs activated by acoustic stimulation at postnatal days 7–11. We analyzed the postnatal maturation of ribbon synapses in the hair cell areas. After acoustic stimulation, the number of ribbon synapses was closer to the mature stage than to the controls. Taken together, these data indicate that early acoustic exposure could promote the functional maturation of cochlear hair cells and the development of hearing.
    Type of Medium: Online Resource
    ISSN: 2090-5904 , 1687-5443
    URL: Article
    DOI: 10.1155/2018/5616930
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2018
    detail.hit.zdb_id: 2236872-3
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  • 4
    Online Resource
    Online Resource
    Analysis of a Viral Infection Model with Delayed Nonlytic Immune Response
    Hindawi Limited ; 2015
    In:  Discrete Dynamics in Nature and Society Vol. 2015 ( 2015), p. 1-11
    Details
    In: Discrete Dynamics in Nature and Society, Hindawi Limited, Vol. 2015 ( 2015), p. 1-11
    Abstract: We investigate the dynamical behavior of a virus infection model with delayed nonlytic immune response. By analyzing corresponding characteristic equations, the local stabilities of two boundary equilibria are established. By using suitable Lyapunov functional and LaSalle’s invariance principle, we establish the global stability of the infection-free equilibrium. We find that the infection free equilibrium E 0 is globally asymptotically stable when R 0 ⩽ 1 , and the infected equilibrium without immunity E 1 is local asymptotically stable when 1 〈 R 0 ⩽ 1 + b β / c d . Under the condition R 0 〉 1 + b β / c d we obtain the sufficient conditions to the local stability of the infected equilibrium with immunity E 2 . We show that the time delay can change the stability of E 2 and lead to the existence of Hopf bifurcations. The stabilities of bifurcating periodic solutions are studied and numerical simulations to our theorems are provided.
    Type of Medium: Online Resource
    ISSN: 1026-0226 , 1607-887X
    URL: Article
    DOI: 10.1155/2015/235420
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2015
    detail.hit.zdb_id: 2033014-5
    SSG: 11
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  • 5
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    Online Resource
    The rs1142345 in TPMT Affects the Therapeutic Effect of Traditional Hypoglycemic Herbs in Prediabetes
    Hindawi Limited ; 2013
    In:  Evidence-Based Complementary and Alternative Medicine Vol. 2013 ( 2013), p. 1-8
    Details
    In: Evidence-Based Complementary and Alternative Medicine, Hindawi Limited, Vol. 2013 ( 2013), p. 1-8
    Abstract: Therapeutic interventions in prediabetes are important in the primary prevention of type 2 diabetes (T2D) and its chronic complications. However, little is known about the pharmacogenetic effect of traditional herbs on prediabetes treatment. A total of 194 impaired glucose tolerance (IGT) subjects were treated with traditional hypoglycemic herbs (Tianqi Jiangtang) for 12 months in this study. DNA samples were genotyped for 184 mutations in 34 genes involved in drug metabolism or transportation. Multinomial logistic regression analysis indicated that rs1142345 ( A 〉 G ) in the thiopurine S-methyltransferase (TPMT) gene was significantly associated with the hypoglycemic effect of the drug ( P = 0.001 , FDR P = 0.043 ). The “G” allele frequencies of rs1142345 in the healthy (subjects reverted from IGT to normal glucose tolerance), maintenance (subjects still had IGT), and deterioration (subjects progressed from IGT to T2D) groups were 0.094, 0.214, and 0.542, respectively. Binary logistic regression analysis indicated that rs1142345 was also significantly associated with the hypoglycemic effect of the drug between the healthy and maintenance groups ( P = 0.027 , OR = 4.828 ) and between the healthy and deterioration groups ( P = 0.001 , OR = 7.811 ). Therefore, rs1142345 was associated with the clinical effect of traditional hypoglycemic herbs. Results also suggested that TPMT was probably involved in the pharmacological mechanisms of T2D.
    Type of Medium: Online Resource
    ISSN: 1741-427X , 1741-4288
    URL: Article
    DOI: 10.1155/2013/327629
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2013
    detail.hit.zdb_id: 2148302-4
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  • 6
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    Effect of Moxibustion on β-EP and Dyn Levels of Pain-Related Indicators in Patients with Rheumatoid Arthritis
    Hindawi Limited ; 2021
    In:  Evidence-Based Complementary and Alternative Medicine Vol. 2021 ( 2021-4-3), p. 1-8
    Details
    In: Evidence-Based Complementary and Alternative Medicine, Hindawi Limited, Vol. 2021 ( 2021-4-3), p. 1-8
    Abstract: Background. Rheumatoid arthritis (RA) is a systemic immunodeficiency disease characterized by persistent synovial inflammation, pannus formation, and bone and cartilage destruction, resulting in joint malformations and function decline. Objective. The purpose of this study is to evaluate the effect of moxibustion on clinical symptoms and levels of pain-related indicators beta-endorphin (β-EP) and dynorphin (Dyn) in patients with RA and to explore the potential anti-inflammatory and analgesic mechanisms of moxibustion in RA treatment. Methods. A total of 64 patients with RA who met the inclusion criteria were randomly and equally classified into the control and treatment groups. The control group received conventional treatment (oral methotrexate, folate, or leflunomide prescribed for a long time). The treatment group was treated with moxibustion at ST36 (Zusanli), BL23 (Shenshu), and Ashi points with respect to the control group. Patients’ clinical symptoms and routine inspection indexes (rheumatoid factor [RF], erythrocyte sedimentation rate [ESR] , and C-reactive protein [CRP]) were recorded before and after treatment. Serum levels of tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), β-EP, and Dyn were determined by enzyme-linked immunosorbent assay (ELISA). The software SPSS24.0 was used for statistical analysis. Results. (1) Compared with the pretreatment result, both of the two groups’ clinical symptoms and routine inspection indexes (RF, ESR, and CRP) improved ( P   〈  0.05), and the improvement of clinical symptoms in the treatment group outperformed that in the control group ( P   〈  0.05). (2) TNF-α and IL-1β levels decreased significantly in the treatment group after treatment ( P   〈  0.01), while no significant difference was observed in the control group ( P   〉  0.05). (3) β-EP and Dyn levels in the treatment group were significantly increased after treatment ( P   〈  0.01, P   〈  0.01), but the control group showed no significant difference ( P   〉  0.05, P   〉  0.05). It is worth mentioning that the serum TNF-α, IL-1β, β-EP, and Dyn levels between the two groups were significantly different after 8 weeks of treatment ( P   〈  0.05). (4) Differences in the serum β-EP and Dyn levels in the patients of the treatment group were correlated with TNF-α and IL-1β levels after treatment, and the correlation was mainly negative (r  〈  0). Conclusion. Moxibustion can improve joint pain in patients with RA using conventional western medicine. One of the mechanisms may affect the serum β-EP and Dyn levels by downregulating the inflammatory factors to play an anti-inflammatory and analgesic role.
    Type of Medium: Online Resource
    ISSN: 1741-4288 , 1741-427X
    URL: Article
    DOI: 10.1155/2021/6637554
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2021
    detail.hit.zdb_id: 2148302-4
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  • 7
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    Effect of Moxibustion on the Serum Levels of MMP-1, MMP-3, and VEGF in Patients with Rheumatoid Arthritis
    Hindawi Limited ; 2020
    In:  Evidence-Based Complementary and Alternative Medicine Vol. 2020 ( 2020-09-17), p. 1-9
    Details
    In: Evidence-Based Complementary and Alternative Medicine, Hindawi Limited, Vol. 2020 ( 2020-09-17), p. 1-9
    Abstract: Background . Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease, which will eventually lead to joints deformity and functional damage. The aim of this research is to evaluate the effect of moxibustion on the serum indicators related to bone and cartilage metabolism, matrix metalloproteinase 1 (MMP-1), matrix metalloproteinase 3 (MMP-3), and vascular endothelial growth factor (VEGF) in patients with RA and to explore the mechanism of moxibustion in the treatment of RA. Methods . We recruited 70 RA patients who met the inclusion criteria, and they were randomly divided into two groups, a treatment group and a control group in equal ratio. The control group took methotrexate, folate, or leflunomide orally, while the treatment group received methotrexate, folate, or leflunomide orally and moxibustion at ST36 (Zusanli), BL23 (Shen shu), and Ashi points. We compared the clinical symptoms, RA serological disease markers and serum contents of interleukin-1 β (IL-1 β ), tumor necrosis factor- α (TNF- α ), MMP-1, MMP-3, and VEGF of RA patients before and after treatment. Results . (1) The clinical symptoms and RA serological disease markers of the two groups improved after treatment ( P   〈  0.05), while the clinical symptoms of the treatment group were significantly improved in comparison with the control group ( P   〈  0.05). (2) The levels of IL-1 β , TNF- α, and VEGF decreased in both groups after treatment ( P   〈  0.05), but the treatment group was significantly decreased compared with the control group ( P   〈  0.05). (3) There were significant differences in MMP-1 and MMP-3 contents after treatment in the treatment group ( P   〈  0.05, P   〈  0.05), while there were no significant differences in the control group ( P   〉  0.05, P   〉  0.05). Above all, the contents of IL-1 β , TNF- α , MMP-1, MMP-3, and VEGF in the treatment group decreased more significantly than those in the control group ( P   〈  0.05). Conclusion . The improvement effect of moxibustion on the clinical symptoms of RA patients may be related to influence on the contents of IL-1 β , TNF- α , MMP-1, MMP-3, and VEGF, and moxibustion may play a potential role in bone protection.
    Type of Medium: Online Resource
    ISSN: 1741-427X , 1741-4288
    URL: Article
    DOI: 10.1155/2020/7150605
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2020
    detail.hit.zdb_id: 2148302-4
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  • 8
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    Understanding the Complexity of Temperature Dynamics in Xinjiang, China, from Multitemporal Scale and Spatial Perspectives
    Hindawi Limited ; 2013
    In:  The Scientific World Journal Vol. 2013 ( 2013), p. 1-9
    Details
    In: The Scientific World Journal, Hindawi Limited, Vol. 2013 ( 2013), p. 1-9
    Abstract: Based on the observed data from 51 meteorological stations during the period from 1958 to 2012 in Xinjiang, China, we investigated the complexity of temperature dynamics from the temporal and spatial perspectives by using a comprehensive approach including the correlation dimension (CD), classical statistics, and geostatistics. The main conclusions are as follows (1) The integer CD values indicate that the temperature dynamics are a complex and chaotic system, which is sensitive to the initial conditions. (2) The complexity of temperature dynamics decreases along with the increase of temporal scale. To describe the temperature dynamics, at least 3 independent variables are needed at daily scale, whereas at least 2 independent variables are needed at monthly, seasonal, and annual scales. (3) The spatial patterns of CD values at different temporal scales indicate that the complex temperature dynamics are derived from the complex landform.
    Type of Medium: Online Resource
    ISSN: 1537-744X
    URL: Article
    DOI: 10.1155/2013/259248
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2013
    detail.hit.zdb_id: 2075968-X
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  • 9
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    A Sparse Gating Convolutional Recurrent Network for Traffic Flow Prediction
    Hindawi Limited ; 2022
    In:  Mathematical Problems in Engineering Vol. 2022 ( 2022-2-22), p. 1-14
    Details
    In: Mathematical Problems in Engineering, Hindawi Limited, Vol. 2022 ( 2022-2-22), p. 1-14
    Abstract: With the continuous development of deep learning, more and more huge deep learning models are developed by researchers, which leads to an exponential increase of the parameters of models. Therein, the convolutional recurrent network as a type of widely used deep learning method is often employed to handle spatiotemporal data, e.g., traffic data. However, because of the large number of parameters in the model, the convolutional recurrent network needs to consume a lot of computing resources and time in the training process. To reduce the consumption of resources, we propose a sparse convolutional recurrent network with a sparse gating mechanism that is able to reduce the complexity of the network by an improved gate unit while keeping the performance of the model. We evaluate the performance of our proposed network on traffic flow datasets, and the experimental results show that the parameters of the model are significantly reduced under the condition of similar prediction accuracy compared with the traditional convolutional recurrent network.
    Type of Medium: Online Resource
    ISSN: 1563-5147 , 1024-123X
    URL: Article
    DOI: 10.1155/2022/6446941
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2022
    detail.hit.zdb_id: 2014442-8
    SSG: 11
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  • 10
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    The Effects of Urethane on Rat Outer Hair Cells
    Hindawi Limited ; 2016
    In:  Neural Plasticity Vol. 2016 ( 2016), p. 1-11
    Details
    In: Neural Plasticity, Hindawi Limited, Vol. 2016 ( 2016), p. 1-11
    Abstract: The cochlea converts sound vibration into electrical impulses and amplifies the low-level sound signal. Urethane, a widely used anesthetic in animal research, has been shown to reduce the neural responses to auditory stimuli. However, the effects of urethane on cochlea, especially on the function of outer hair cells, remain largely unknown. In the present study, we compared the cochlear microphonic responses between awake and urethane-anesthetized rats. The results revealed that the amplitude of the cochlear microphonic was decreased by urethane, resulting in an increase in the threshold at all of the sound frequencies examined. To deduce the possible mechanism underlying the urethane-induced decrease in cochlear sensitivity, we examined the electrical response properties of isolated outer hair cells using whole-cell patch-clamp recording. We found that urethane hyperpolarizes the outer hair cell membrane potential in a dose-dependent manner and elicits larger outward current. This urethane-induced outward current was blocked by strychnine, an antagonist of the α 9 subunit of the nicotinic acetylcholine receptor. Meanwhile, the function of the outer hair cell motor protein, prestin, was not affected. These results suggest that urethane anesthesia is expected to decrease the responses of outer hair cells, whereas the frequency selectivity of cochlea remains unchanged.
    Type of Medium: Online Resource
    ISSN: 2090-5904 , 1687-5443
    URL: Article
    DOI: 10.1155/2016/3512098
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2016
    detail.hit.zdb_id: 2236872-3
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