GLORIA

GEOMAR Library Ocean Research Information Access

X

Ihre E-Mail wurde erfolgreich gesendet. Bitte prüfen Sie Ihren Maileingang.

Leider ist ein Fehler beim E-Mail-Versand aufgetreten. Bitte versuchen Sie es erneut.

Vorgang fortführen?

Exportieren
  • 1
    Online-Ressource
    Online-Ressource
    Assessment of biomarkers influencing treatment success on small intestinal lymphoma in dogs
    Wiley ; 2021
    In:  Veterinary and Comparative Oncology Vol. 19, No. 1 ( 2021-03), p. 123-131
    Details
    In: Veterinary and Comparative Oncology, Wiley, Vol. 19, No. 1 ( 2021-03), p. 123-131
    Kurzfassung: This study aimed to determine a reliable therapeutic biomarker for localized small intestinal lymphoma (SIL) in dogs based on clinical and histopathological features. We retrospectively investigated 84 dogs with localized SIL, including 36 dogs receiving surgery and 48 dogs receiving chemotherapy. The dogs receiving surgery were divided into two subgroups: 18 dogs (group 1) with overall survival (OS) 〈 120 days (median OS) and 18 dogs (group 2) with OS ≥120 days. Correspondingly, the dogs receiving chemotherapy were divided into 24 dogs (group 3) with OS 〈 98 days (median OS) and 24 dogs (group 4) with OS ≥98 days. Clinical, haematological, histopathological and immunohistochemical analyses were comparatively evaluated among the four subgroups. There was no significant difference in OS between the surgery and chemotherapy groups. In dogs receiving surgery, the rate of Ki67‐positive cells was significantly increased in group 1 compared to group 2 and showed no significant difference between groups 3 and 4. In dogs receiving chemotherapy, the rate of O6‐methylguanine‐DNA methyltransferase (MGMT) was significantly higher in group 3 than in group 4 and showed no significant difference between groups 1 and 2. Additionally, our data showed that OS in dogs with higher Ki67 expression might be significantly increased by chemotherapy than by surgery, that of those with higher MGMT expression might be significantly increased by surgery than by chemotherapy, and Ki67 and MGMT were independent of each other. Indices of Ki67 and MGMT are suggested therapeutic biomarkers to determine the optimal first‐line treatment for localized SIL in dogs.
    Materialart: Online-Ressource
    ISSN: 1476-5810 , 1476-5829
    URL: Issue
    URL: Article
    DOI: 10.1111/vco.v19.1
    DOI: 10.1111/vco.12653
    Sprache: Englisch
    Verlag: Wiley
    Publikationsdatum: 2021
    ZDB Id: 2129634-0
    SSG: 22
    Standort Signatur Einschränkungen Verfügbarkeit
    BibTip Andere fanden auch interessant ...
    Online-Ressource
  • 2
    Online-Ressource
    Online-Ressource
    Assessment of hypoxia-targeting therapy for gastrointestinal lymphoma in dogs: Preclinical test using murine models
    Elsevier BV ; 2023
    In:  Research in Veterinary Science Vol. 154 ( 2023-01), p. 22-28
    Details
    In: Research in Veterinary Science, Elsevier BV, Vol. 154 ( 2023-01), p. 22-28
    Materialart: Online-Ressource
    ISSN: 0034-5288
    URL: Article
    DOI: 10.1016/j.rvsc.2022.11.003
    Sprache: Englisch
    Verlag: Elsevier BV
    Publikationsdatum: 2023
    ZDB Id: 2002535-X
    SSG: 22
    Standort Signatur Einschränkungen Verfügbarkeit
    BibTip Andere fanden auch interessant ...
    Online-Ressource
  • 3
    Online-Ressource
    Online-Ressource
    Computed tomography and magnetic resonance imaging findings in dogs with vaginal leiomyoma and leiomyosarcoma
    Wiley ; 2022
    In:  Veterinary Medicine and Science Vol. 8, No. 6 ( 2022-11), p. 2337-2344
    Details
    In: Veterinary Medicine and Science, Wiley, Vol. 8, No. 6 ( 2022-11), p. 2337-2344
    Kurzfassung: In humans, magnetic resonance imaging (MRI) is preferred over computed tomography (CT) for the assessment of pelvic lesions. Although CT findings of several pelvic tumours have been reported in veterinary medicine, MRI findings are limited. Objectives The purpose of this study was to retrospectively compare the CT and MRI findings in dogs with vaginal leiomyoma and leiomyosarcoma. Methods This retrospective study of five dogs compared the CT and MRI findings of intrapelvic lesions, including vaginal leiomyoma ( n  = 4) and leiomyosarcoma ( n  = 1). No invasion of the surrounding tissue was detected on histopathological examination. In this retrospective study, the following parameters of CT and MRI were recorded for each dog: the border between the lesion and the adjacent pelvic organs, including the prostate, rectum or urethra; signal intensity (SI) of the lesion; enhancement pattern; presence of haemorrhage; necrosis or cystic areas and lymphadenopathy. Because SI on MRI is affected by cell density, tumour cell density was analysed using a microscope slide. Results In vaginal leiomyoma, the border between the lesion and the surrounding pelvic organ tends to be clearer on MRI than on CT. In vaginal leiomyosarcoma, the border was comparable between MRI and CT. Each lesion showed heterogeneous enhancement on CT and MRI scans. In each lesion, the assessment of haemorrhage, necrosis, cystic areas and lymphadenopathy was comparable between MRI and CT. The SI of the lesion on T2WI of the vaginal leiomyoma and leiomyosarcoma were hyperintense in four cases (4/4; 100%) and mixed intense in one case (1/1; 100%), respectively. The cell density of leiomyosarcoma is higher than that of leiomyomas. Conclusions The SI on T2WI may be useful for differentiating leiomyoma from leiomyosarcoma. MRI may be useful to differentiate vaginal leiomyomas from leiomyosarcomas and evaluate margins.
    Materialart: Online-Ressource
    ISSN: 2053-1095 , 2053-1095
    URL: Issue
    URL: Article
    DOI: 10.1002/vms3.v8.6
    DOI: 10.1002/vms3.930
    Sprache: Englisch
    Verlag: Wiley
    Publikationsdatum: 2022
    ZDB Id: 2819409-3
    Standort Signatur Einschränkungen Verfügbarkeit
    BibTip Andere fanden auch interessant ...
    Online-Ressource
  • 4
    Online-Ressource
    Online-Ressource
    Computed tomography may detect liver infiltration of canine diffuse hepatic lymphoma
    Wiley ; 2021
    In:  Veterinary Medicine and Science Vol. 7, No. 6 ( 2021-11), p. 2172-2177
    Details
    In: Veterinary Medicine and Science, Wiley, Vol. 7, No. 6 ( 2021-11), p. 2172-2177
    Kurzfassung: In dogs, hepatic lymphoma is characterized by neoplastic lymphocyte infiltration into the liver. Reports on the computed tomography (CT) findings of the liver for canine hepatic lymphoma are few, with only one study of multiple liver lesions type. Objectives The purpose of this study was to retrospectively assess the CT findings of the liver in canine diffuse hepatic lymphoma. Methods As control, five dogs without abnormalities in the liver were included. CT data were analysed, and the following were noted: presence of edge bluntness of the liver, presence of periportal collar sign, the liver size:body weight (BW) ratio and the mean attenuation of liver lesions on pre‐contrast, arterial‐phase, portal‐phase and equilibrium‐phase post‐contrast images. Results On CT examination, edge bluntness of the liver was significantly detected in lymphoma (4/5, 80%), as opposed to the control (0/5, 0%) ( p  = 0.048, φ = 0.82). The periportal collar sign was detected in lymphoma (3/5, 60%), as opposed to the control (0/5, 0%) ( p  = 0.17, φ = 0.65). The liver size:BW ratio of lymphoma cases was significantly higher compared to that of the control cases ( p  = 0.0002, r  = 0.92). The mean Hounsfield unit of lymphoma cases in the pre‐contrast, arterial‐phase, portal‐phase and equilibrium‐phase images were significantly lower than in the control cases ( p  = 0.005, r  = 0.81; p  = 0.0003, r  = 0.91; p  = 0.01, r  = 0.75 and p  = 0.02, r  = 0.71, respectively). Conclusions Hepatic lymphoma should be a differential for a blunted and enlarged liver with hypoattenuation on CT examination.
    Materialart: Online-Ressource
    ISSN: 2053-1095 , 2053-1095
    URL: Issue
    URL: Article
    DOI: 10.1002/vms3.v7.6
    DOI: 10.1002/vms3.598
    Sprache: Englisch
    Verlag: Wiley
    Publikationsdatum: 2021
    ZDB Id: 2819409-3
    Standort Signatur Einschränkungen Verfügbarkeit
    BibTip Andere fanden auch interessant ...
    Online-Ressource
  • 5
    Online-Ressource
    Online-Ressource
    MRI findings, including diffusion-weighted imaging and apparent diffusion coefficient value, in two cats with nasopharyngeal polyps and one cat with lymphoma
    SAGE Publications ; 2018
    In:  Journal of Feline Medicine and Surgery Open Reports Vol. 4, No. 2 ( 2018-07), p. 205511691881225-
    Details
    In: Journal of Feline Medicine and Surgery Open Reports, SAGE Publications, Vol. 4, No. 2 ( 2018-07), p. 205511691881225-
    Kurzfassung: Most nasopharyngeal masses in cats are lymphomas or polyps. To our knowledge, there is no report of MRI findings, including diffusion-weighted imaging (DWI) or apparent diffusion coefficient (ADC) values, of nasopharyngeal lymphomas and nasopharyngeal polyps in cats. This study aimed to evaluate the MRI findings of nasopharyngeal lymphomas and nasopharyngeal polyps, including DWI and ADC values. Methods MRI examination was performed on two cats with a histologically confirmed nasopharyngeal polyp and one cat with lymphoma. The magnetic resonance scanning protocol included T2-weighted imaging (T2WI), T1-weighted imaging (T1WI) and DWI. An ADC map was created based on DWI. ADC values were then calculated. Results MRI of the nasopharyngeal polyps revealed well-defined masses with strong rim enhancement, mass-associated stalk-like structures and asymmetric tympanic bulla lesions. The polyps appeared hyperintense on T2WI, hypo- to isointense on T1WI, and of mixed intensity or hypointense on DWI. On the ADC map, the masses appeared hyperintense. The ADC values of the polyps were 2.07 × 10 −3 mm 2 /s and 2.28 × 10 −3 mm 2 /s. MRI examination of the nasopharyngeal lymphoma revealed a strongly enhancing heterogeneous lesion. The mass appeared mildly hyperintense on T2WI, isointense on T1WI and hyperintense on DWI. On the ADC map, the mass appeared hypointense. The ADC value of the mass was 0.46 ×10 −3 mm 2 /s. The ADC values of the nasopharyngeal polyps were higher than the ADC value of the nasopharyngeal lymphoma. Conclusions and relevance Measurement of ADC values may be useful for differentiating between nasopharyngeal polyps and nasopharyngeal lymphomas.
    Materialart: Online-Ressource
    ISSN: 2055-1169 , 2055-1169
    URL: Article
    DOI: 10.1177/2055116918812254
    Sprache: Englisch
    Verlag: SAGE Publications
    Publikationsdatum: 2018
    ZDB Id: 2822177-1
    Standort Signatur Einschränkungen Verfügbarkeit
    BibTip Andere fanden auch interessant ...
    Online-Ressource
  • 6
    Online-Ressource
    Online-Ressource
    Contrast‐enhanced CT features of pyloric lesions in 17 dogs: Case series
    Wiley ; 2023
    In:  Veterinary Radiology & Ultrasound Vol. 64, No. 2 ( 2023-03), p. 262-270
    Details
    In: Veterinary Radiology & Ultrasound, Wiley, Vol. 64, No. 2 ( 2023-03), p. 262-270
    Kurzfassung: Pyloric outflow obstructions can be caused by several types of lesions. When a thickened gastric wall and pyloric mass are detected, malignant neoplasia must be differentiated from chronic hypertrophic pyloric gastropathy. CT can characterize gastric tumors. However, based on the authors’ review of the literature, there is limited information about the CT findings of pyloric lesions. The purpose of this retrospective case series study was to assess the CT findings of canine pyloric lesions. The following CT parameters were recorded: anatomical area, involved area, lesion shape, growth patterns of wall thickening lesions, enhancement pattern of the lesion in the early and delayed phases, lymphomegaly, and pulmonary metastasis. Seventeen dogs were included in this study and had the following final diagnoses: hyperplasia (five dogs), adenoma (five dogs), adenocarcinoma (three dogs), gastrointestinal stromal tumor (GIST; two dogs), polyposis (one dog), and pyogenic granuloma (one dog). Hyperplasia, adenoma, and polyposis formed mass lesions that involved the mucosal layer. Lymphomegaly was detected in two Jack Russell terriers with hyperplasia; however, the causes were unknown because we did not perform biopsies. All adenocarcinomas formed wall‐thickened lesion that involved the outer layer, with lymphomegaly. All GISTs formed mass lesion that involved the outer layer. The pyogenic granulomas formed symmetric wall‐thickened lesion that involved the mucosal and outer layers. CT facilitated the characterization of canine pyloric lesions using contrast enhancement, based on the involved area and lesion shape. However, polyposis may require caution in diagnosis based on CT findings alone.
    Materialart: Online-Ressource
    ISSN: 1058-8183 , 1740-8261
    URL: Issue
    URL: Article
    DOI: 10.1111/vru.v64.2
    DOI: 10.1111/vru.13193
    Sprache: Englisch
    Verlag: Wiley
    Publikationsdatum: 2023
    ZDB Id: 2142058-0
    SSG: 22
    Standort Signatur Einschränkungen Verfügbarkeit
    BibTip Andere fanden auch interessant ...
    Online-Ressource
  • 7
    Online-Ressource
    Online-Ressource
    Preliminary study of CT features of intermediate- and high-grade alimentary lymphoma and adenocarcinoma in cats
    SAGE Publications ; 2022
    In:  Journal of Feline Medicine and Surgery Vol. 24, No. 10 ( 2022-10), p. 1065-1071
    Details
    In: Journal of Feline Medicine and Surgery, SAGE Publications, Vol. 24, No. 10 ( 2022-10), p. 1065-1071
    Kurzfassung: The ultrasonographic findings of many feline intestinal tumours are similar. This study evaluated the CT features of intermediate- and high-grade alimentary lymphoma and adenocarcinoma in cats. CT was performed on six cats with adenocarcinoma and 14 cats with lymphoma. Comparisons between tumour types were conducted, focusing on CT features, including obstruction (present or absent), growth patterns of lesions (symmetry or asymmetry), layering enhancement (present or absent), location of the lesion, number of lesions (solitary or multiple), lymphadenopathy (present or absent), location of lymphadenopathy, pulmonary metastasis (present or absent) and maximum thickness (mm) of the lesion. The cats with adenocarcinoma (n = 5/6 [83%] ) experienced intestinal obstruction significantly more often than cats with lymphoma (n = 0/14 [0%]; P = 0.0004). Layering enhancement was observed significantly more often in cats with adenocarcinoma (n = 6/6 [100%] ) than in cats with lymphoma (n = 1/14 [7%]; P = 0.0002). Lymphadenopathy was detected significantly more often in cats with lymphoma (n = 14/14 [100%] ) than in cats with adenocarcinoma (n = 2/6 [33%]) ( P = 0.003). In cats with lymphoma, the intestine (12.1 ± 3.9 mm) was significantly thicker than that in cats with adenocarcinoma (6.4 ± 2.3 mm; P = 0.005). Relevance and novel information To the best of our knowledge, no reports have described the characteristics of feline intestinal tumours using CT. Layering enhancement was observed in cats with intestinal adenocarcinomas. No layering enhancement was observed in alimentary lymphoma in cats, but enlarged regional nodes were noted. Lesions with lymphoma were thicker than those with adenocarcinoma. These findings may help differentiate between adenocarcinomas and lymphomas.
    Materialart: Online-Ressource
    ISSN: 1098-612X , 1532-2750
    URL: Article
    DOI: 10.1177/1098612X211046847
    Sprache: Englisch
    Verlag: SAGE Publications
    Publikationsdatum: 2022
    ZDB Id: 2049047-1
    SSG: 22
    Standort Signatur Einschränkungen Verfügbarkeit
    BibTip Andere fanden auch interessant ...
    Online-Ressource
  • 8
    Online-Ressource
    Online-Ressource
    Less enhancement and low apparent diffusion coefficient value on magnetic resonance imaging may be helpful to detect canine prostate adenocarcinoma in case series
    Wiley ; 2020
    In:  Veterinary and Comparative Oncology Vol. 18, No. 4 ( 2020-12), p. 861-865
    Details
    In: Veterinary and Comparative Oncology, Wiley, Vol. 18, No. 4 ( 2020-12), p. 861-865
    Kurzfassung: In dogs, diagnosis of prostate cancer is often delayed because clinical signs are not pathognomonic. Although ultrasonography is mainly performed to detect prostate cancer, the ultrasonographic appearance is not specific. In humans, magnetic resonance imaging (MRI), including diffusion‐weighted imaging (DWI) is used to localize the prostate tumour. To our knowledge, there are no studies of MRI findings for detecting or localizing prostate cancer. The purpose of this study was to assess MRI findings of prostate cancer. As a control, three prostate hyperplasia cases were included. MRI data were analysed, and the following parameters were noted: signal intensity (SI) of prostate lesion on T2‐weighted imaging, T1‐weighted imaging and DWI, enhancement pattern of prostate lesion, and relative contrast enhancement indices (RCEI) and apparent diffusion coefficient (ADC) value of prostate lesion. For MRI examination, the mean RCEI of the adenocarcinoma was significantly lower than that of hyperplasia ( P = .01, r = .8). The SI of the DWI of adenocarcinoma was significantly higher compared to hyperplasia ( P = .03, φ = 1). The mean ADC values of the adenocarcinoma were significantly lower than that of hyperplasia ( P = .03, r = .82). Thus, less enhancement on MRI, and low ADC value on MRI may help to detect prostate adenocarcinoma.
    Materialart: Online-Ressource
    ISSN: 1476-5810 , 1476-5829
    URL: Issue
    URL: Article
    DOI: 10.1111/vco.v18.4
    DOI: 10.1111/vco.12578
    Sprache: Englisch
    Verlag: Wiley
    Publikationsdatum: 2020
    ZDB Id: 2129634-0
    SSG: 22
    Standort Signatur Einschränkungen Verfügbarkeit
    BibTip Andere fanden auch interessant ...
    Online-Ressource
  • 9
    Online-Ressource
    Online-Ressource
    Assessment of Hypoxia-Targeting Therapy for Intestinal T-Cell Lymphoma in Dogs: Preclinical Test Using Murine Models
    Elsevier BV ; 2022
    In:  SSRN Electronic Journal
    Details
    In: SSRN Electronic Journal, Elsevier BV
    Materialart: Online-Ressource
    ISSN: 1556-5068
    URL: Article
    DOI: 10.2139/ssrn.4090297
    Sprache: Englisch
    Verlag: Elsevier BV
    Publikationsdatum: 2022
    Standort Signatur Einschränkungen Verfügbarkeit
    BibTip Andere fanden auch interessant ...
    Online-Ressource
  • 10
    Online-Ressource
    Online-Ressource
    Case Report: Detection of Transferrin in a Dog Suspected of Having Cerebrospinal Fluid Rhinorrhea
    Frontiers Media SA ; 2022
    In:  Frontiers in Veterinary Science Vol. 9 ( 2022-3-4)
    Details
    In: Frontiers in Veterinary Science, Frontiers Media SA, Vol. 9 ( 2022-3-4)
    Kurzfassung: A 12-year-old Yorkshire terrier was referred for epileptic seizures and nasal discharge. The fluid was clear and serous. Cerebrospinal fluid (CSF) rhinorrhea was suspected, based on clinical signs and MRI findings. In humans, analysis of nasal secretions to determine the concentration of glucose and brain-type transferrin has been widely used clinically in order to confirm the presence of CSF rhinorrhea. The glucose concentration in the nasal discharge was 74 mg/dL. Serum-type and brain-type isoforms of transferrin were detectable in the nasal sample. The concentration of glucose and brain-type transferrin could be useful for diagnosing CSF rhinorrhea.
    Materialart: Online-Ressource
    ISSN: 2297-1769
    URL: Article
    DOI: 10.3389/fvets.2022.845809
    Sprache: Unbekannt
    Verlag: Frontiers Media SA
    Publikationsdatum: 2022
    ZDB Id: 2834243-4
    Standort Signatur Einschränkungen Verfügbarkeit
    BibTip Andere fanden auch interessant ...
    Online-Ressource
Schließen ⊗
Diese Webseite nutzt Cookies und das Analyse-Tool Matomo. Weitere Informationen finden Sie hier...