In:
PLOS ONE, Public Library of Science (PLoS), Vol. 17, No. 2 ( 2022-2-14), p. e0263844-
Abstract:
We examined the association between serum miRNA (-192-5p, -122-3p, -320a and -6126-5p) levels and the efficacy of pegylated interferon (Peg-IFN) monotherapy for chronic hepatitis B (CHB) patients. We enrolled 61 CHB patients treated with Peg-IFNα-2a weekly for 48 weeks, of whom 12 had a virological response (VR) and 49 did not VR (non-VR). A VR was defined as HBV DNA 〈 2,000 IU/ml, hepatitis B e antigen (HBeAg)-negative, and nucleos(t)ide analogue free at 48 weeks after the end of treatment. The non-VR group showed a significantly higher HBeAg-positivity rate, ALT, HBV DNA, and serum miR-192-5p levels at baseline ( P = 0.024, P = 0.020, P = 0.007, P = 0.021, respectively). Serum miR-192-5p levels at 24-weeks after the start of treatment were also significantly higher in the non-VR than the VR group ( P = 0.011). Multivariate logistic regression analysis for predicting VR showed that miR-192-5p level at baseline was an independent factor (Odds 4.5, P = 0.041). Serum miR-192-5p levels were significantly correlated with the levels of HBV DNA, hepatitis B core-related antigen, and hepatitis B surface antigen (r = 0.484, 0.384 and 0.759, respectively). The serum miR-192-5p level was useful as a biomarker for the therapeutic efficacy of Peg-IFN in CHB treatment.
Type of Medium:
Online Resource
ISSN:
1932-6203
DOI:
10.1371/journal.pone.0263844
DOI:
10.1371/journal.pone.0263844.g001
DOI:
10.1371/journal.pone.0263844.g002
DOI:
10.1371/journal.pone.0263844.t001
DOI:
10.1371/journal.pone.0263844.t002
DOI:
10.1371/journal.pone.0263844.t003
DOI:
10.1371/journal.pone.0263844.t004
DOI:
10.1371/journal.pone.0263844.t005
DOI:
10.1371/journal.pone.0263844.t006
DOI:
10.1371/journal.pone.0263844.s001
DOI:
10.1371/journal.pone.0263844.s002
DOI:
10.1371/journal.pone.0263844.s003
DOI:
10.1371/journal.pone.0263844.s004
DOI:
10.1371/journal.pone.0263844.s005
DOI:
10.1371/journal.pone.0263844.s006
DOI:
10.1371/journal.pone.0263844.r001
DOI:
10.1371/journal.pone.0263844.r002
DOI:
10.1371/journal.pone.0263844.r003
DOI:
10.1371/journal.pone.0263844.r004
DOI:
10.1371/journal.pone.0263844.r005
DOI:
10.1371/journal.pone.0263844.r006
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2022
detail.hit.zdb_id:
2267670-3
Permalink