In:
Annals of Noninvasive Electrocardiology, Wiley, Vol. 21, No. 2 ( 2016-03), p. 126-135
Abstract:
The distribution of late gadolinium enhancement (LGE) on the cardiac MRI (CMR) indicates myocardial fibrosis and provides information of possible reentry substrates. QT dynamicity reflecting repolarization abnormalities has gained attention as a potential prognostic predictive factor. Objective To clarify the correlation between the LGE distribution on CMR and QT dynamicity represented by the QT/RR relationship. Methods CMR and QT/RR analyses using Holter monitoring were performed in 34 patients (24 males, 60 ± 11 years) with ventricular tachycardia (VT) and/or ventricular fibrillation (VF). The LGE on CMR was scored using a 4‐point score in 17 left ventricular segments. The sum of the LGE scores was calculated for each patient. The QT/RR slope and daytime/nighttime QT/RR ratio (day/night ratio) were calculated. The correlation between the slope or the day/night QT/RR ratio and late enhancement findings was analyzed. Results All patients were divided into 23 LGE positive (LGE(+)) and 11 LGE negative (LGE(−)) patients. The slopes of the QTe/RR and QTa /RR were significantly steeper in the LGE(+) than in LGE(−) patients (0.21 ± 0.03 vs 0.13 ± 0.02; P 〈 0.001, 0.19 ± 0.03 vs 0.13 ± 0.02; P 〈 0.001, respectively), and both slopes were significantly correlated with the total LGE scores (r = 0.83, P 〈 0.001; r = 0.71, P 〈 0.001, respectively). In the LGE(+) patients, the QTe day/night (1.37 ± 0.38 vs 0.91 ± 0.33; P = 0.002) and QTa day/night ratios (1.33 ± 0.26 vs 1.06 ± 0.30; P = 0.011) were significantly greater than those in the LGE(−) patients. Conclusion The LGE distribution was closely related to the QT dynamicity, suggesting that a combination of these markers can be a powerful tool for understanding the background pathophysiology.
Type of Medium:
Online Resource
ISSN:
1082-720X
,
1542-474X
DOI:
10.1111/anec.2016.21.issue-2
Language:
English
Publisher:
Wiley
Publication Date:
2016
detail.hit.zdb_id:
2111515-1
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