In:
Pulmonary Circulation, Wiley, Vol. 9, No. 1 ( 2019-01), p. 1-9
Abstract:
Chronic thromboembolic pulmonary hypertension (CTEPH) can cause right heart failure. A concomitant psychiatric disorder (PD) is thought to increase the risk of acute pulmonary thromboembolism; however, whether PDs are associated with deterioration in CTEPH pathophysiology is unclear. In this study, we evaluated the clinical characteristics and prognoses in patients with CTEPH and a co‐existing PD. We retrospectively identified 229 consecutive patients (mean age = 58.7 ± 12.5 years; 160 women) with CTEPH and categorized them according to whether they had a PD (PD group; n = 22, 9.7%) or not (non‐PD group; n = 207, 90.3%). We compared the clinical characteristics, respiratory function, hemodynamics, and clinical courses in the two groups. Those in the PD group had significantly lower exercise tolerance compared to the non‐PD group (6‐min walk test, 309.5 ± 89.5 m vs. 369.4 ± 97.9 m, P = 0.008, percent vital capacity 85.5% ± 17.3% vs. 96.0% ± 15.5%, P = 0.003) and partial pressure of oxygen (PaO 2 ) (54.4 ± 8.6 mmHg vs. 59.3 ± 10.7 mmHg, P = 0.039). Three‐year survival was significantly poorer in the PD group compared to the non‐PD group (66.1% vs 89.7%, P = 0.0026, log‐rank test), particularly in patients who underwent surgery (62.2% vs 89.5%, P 〈 0.001, log‐rank test). A concomitant PD was associated with low exercise tolerance and impaired respiratory function in patients with CTEPH and predicted poor survival, especially in those who underwent a pulmonary endarterectomy.
Type of Medium:
Online Resource
ISSN:
2045-8940
,
2045-8940
DOI:
10.1177/2045894019836420
Language:
English
Publisher:
Wiley
Publication Date:
2019
detail.hit.zdb_id:
2638089-4
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