In:
Blood Purification, S. Karger AG, Vol. 19, No. 1 ( 2001), p. 10-14
Abstract:
〈 i 〉 Aims: 〈 /i 〉 In order to assess the long-term influence of high-flux hemodiafiltration (HDF) on hemodynamic stability in patients with dialysis-related amyloidosis. 〈 i 〉 Methods: 〈 /i 〉 HDF with high-flux dialyzers was performed for a year in 11 patients who had undergone the surgery for carpal tunnel syndrome. Patients were divided into two groups, and for each group synthetic or cellulose membrane dialyzers were applied. 〈 i 〉 Results: 〈 /i 〉 A year after the exchange from standard hemodialysis to HDF with cellulose high-flux dialyzers, β 〈 sub 〉 2 〈 /sub 〉 -microglobulin was decreased (45 ± 3 to 28 ± 2 mg/l, n = 5, p 〈 0.05), but plasma non-refilling ratio was not altered. However, the continuance of synthetic high-flux HDF for a year decreased plasma non-refilling ratio (17 ± 5 to 7 ± 4%, p 〈 0.05), hypotensive episodes (4.3 ± 0.6 to 2.5 ± 0.4 sessions/month, p 〈 0.05) and muscle cramps (3.8 ± 0.5 to 1.8 ± 0.5 sessions/month, p 〈 0.01) in addition to the decrements in serum β 〈 sub 〉 2 〈 /sub 〉 -microglobulin (45 ± 5 to 33 ± 2 mg/l, n = 6, p 〈 0.01). 〈 i 〉 Conclusions: 〈 /i 〉 Although the study on a large number of patients may be required to draw a final conclusion, our present data suggest that biocompatible high-flux HDF is uniquely suited for dialysis-related amyloidosis.
Type of Medium:
Online Resource
ISSN:
0253-5068
,
1421-9735
Language:
English
Publisher:
S. Karger AG
Publication Date:
2001
detail.hit.zdb_id:
1482025-0
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