In:
Current Neurovascular Research, Bentham Science Publishers Ltd., Vol. 17, No. 3 ( 2020-09-29), p. 286-293
Abstract:
Cerebral ischemia causes a strong inflammatory response. Neumentix is a
dietary supplement containing 14.9% rosmarinic acid and 29.9% total phenolic content, which has
been proved to be beneficial against inflammatory response. Therefore, Neumentix’s effect on anti-inflammatory and blood brain barrier (BBB) disruption in transient middle cerebral artery occlusion
(tMCAO) model mice is investigated in this study. Methods: After the pretreatment of vehicle or Neumentix 134 mg/kg/d, intraperitoneal injection
(i.p.) (containing rosmarinic acid 20 mg/kg/d) for 14 days, mice were subjected to tMCAO for 60 min and kept receiving vehicle or Neumentix daily 5 days afterward. Results: Neumentix treatment ameliorated neurobehavioral impairment in the corner test (5d after
tMCAO, **P 〈 0.01), reduced infarct volume (#P 〈 0.05), suppressed expression of ionized calciumbinding
adapter molecule-1 (Iba-1), tumor necrosis factor alpha (TNF-α) and monocyte chemoattractant protein-1 (MCP-1) (###P 〈 0.001), and improved the integrity of BBB (§P 〈 0.05) at 5 days
after tMCAO. Conclusios: The present study provided an evidence of Neumentix’s anti-inflammatory and neuroprotection
effect against BBB disruption on experimental tMCAO model mice, suggesting that Neumentix could be a potential therapeutic agent for stroke.
Type of Medium:
Online Resource
ISSN:
1567-2026
DOI:
10.2174/1567202617666200517105727
Language:
English
Publisher:
Bentham Science Publishers Ltd.
Publication Date:
2020
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