In:
International Archives of Allergy and Immunology, S. Karger AG, Vol. 182, No. 6 ( 2021), p. 535-545
Abstract:
〈 b 〉 〈 i 〉 Introduction: 〈 /i 〉 〈 /b 〉 Eosinophilic chronic rhinosinusitis (ECRS) is a refractory chronic disease defined by recurrent nasal polyps with severe eosinophilic infiltration. This is mainly due to enhanced type 2-dominant immune responses, but the underlying mechanism is still not fully understood. 〈 b 〉 〈 i 〉 Objective and Methods: 〈 /i 〉 〈 /b 〉 In the present study, we aimed to determine the characteristics of dendritic cells (DCs) and cytokine profiles of T cells in the peripheral blood of individuals with ECRS and age- and sex-matched healthy controls (HC). 〈 b 〉 〈 i 〉 Results and Conclusion: 〈 /i 〉 〈 /b 〉 The ratios of myeloid (m)DC1s to DCs and PD-L1 〈 sup 〉 + 〈 /sup 〉 mDC1s to mDC1s were higher in ECRS patients than in HC. The proportions of plasmacytoid (p)DCs in DCs, and human leukocyte antigen-DR 〈 sup 〉 + 〈 /sup 〉 pDCs and ILT3 〈 sup 〉 + 〈 /sup 〉 pDCs in pDCs were lower in ECRS patients than in HC. In a characterization of T cells, IL-4 〈 sup 〉 + 〈 /sup 〉 CD4 〈 sup 〉 + 〈 /sup 〉 , IFN-γ 〈 sup 〉 + 〈 /sup 〉 CD4 〈 sup 〉 + 〈 /sup 〉 , IL-4 〈 sup 〉 + 〈 /sup 〉 IFN-γ 〈 sup 〉 + 〈 /sup 〉 CD4 〈 sup 〉 + 〈 /sup 〉 , IL-4 〈 sup 〉 + 〈 /sup 〉 Foxp3 〈 sup 〉 + 〈 /sup 〉 CD4 〈 sup 〉 + 〈 /sup 〉 , IFN-γ 〈 sup 〉 + 〈 /sup 〉 Foxp3 〈 sup 〉 + 〈 /sup 〉 CD4 〈 sup 〉 + 〈 /sup 〉 , IFN-γ 〈 sup 〉 + 〈 /sup 〉 IL-4 〈 sup 〉 − 〈 /sup 〉 Foxp3 〈 sup 〉 − 〈 /sup 〉 CD4 〈 sup 〉 + 〈 /sup 〉 , IL-4 〈 sup 〉 + 〈 /sup 〉 CD8 〈 sup 〉 + 〈 /sup 〉 , IL-4 〈 sup 〉 + 〈 /sup 〉 IFN-γ 〈 sup 〉 + 〈 /sup 〉 CD8 〈 sup 〉 + 〈 /sup 〉 , and IL-4 〈 sup 〉 + 〈 /sup 〉 Foxp3 〈 sup 〉 + 〈 /sup 〉 CD8 〈 sup 〉 + 〈 /sup 〉 T-cell populations were significantly higher in ECRS patients than in HC. These results suggest that the enhanced immune regulation of mDC1, diminished capacity of pDCs, and increased proportion of the T-cell phenotypes in peripheral blood might be factors in ECRS pathogenesis.
Type of Medium:
Online Resource
ISSN:
1018-2438
,
1423-0097
Language:
English
Publisher:
S. Karger AG
Publication Date:
2021
detail.hit.zdb_id:
1482722-0
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