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  • SAGE Publications  (6)
  • Takaso, Masashi  (6)
  • 1
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    Online Resource
    Origin of M2 Mϕ and its macrophage polarization by TGF-β in a mice intervertebral injury model
    SAGE Publications ; 2022
    In:  International Journal of Immunopathology and Pharmacology Vol. 36 ( 2022-01), p. 039463202211037-
    Details
    In: International Journal of Immunopathology and Pharmacology, SAGE Publications, Vol. 36 ( 2022-01), p. 039463202211037-
    Abstract: Studies have identified the presence of M1 and M2 macrophages (Mϕ) in injured intervertebral discs (IVDs). However, the origin and polarization-regulatory factor of M2 Mϕ are not fully understood. TGF-β is a regulatory factor for M2 polarization in several tissues. Here, we investigated the source of M2 Mϕ and the role of TGF-β on M2 polarization using a mice disc-puncture injury model. Methods To investigate the origin of M2 macrophages, 30 GFP chimeric mice were created by bone marrow transplantation. IVDs were obtained from both groups on pre-puncture (control) and post-puncture days 1, 3, 7, and 14 and CD86 (M1 marker)- and CD206 (M2 marker)-positive cells evaluated by flow cytometry ( n = 5 at each time point). To investigate the role of TGF-β on M2 polarization, TGF-β inhibitor (SB431542) was also injected on post-puncture days (PPD) 5 and 6 and CD206 expression was evaluated on day 7 by flow cytometry ( n = 5) and real time PCR ( n = 10). Results The proportion of CD86 + Mϕ within the GFP+ population was significantly increased at PPD 1, 3, 7, and 14 compared to control. CD206-positive cells in GFP-populations were significantly increased on PPD 7 and 14. In addition, the percentage of CD206-positive cells was significantly higher in GFP-populations than in GFP+ populations. TGF-β inhibitor reduced CD206-positive cells and Cd206 expression at 7 days after puncture. Conclusion Our findings suggest that M2 Mϕ following IVD injury may originate from resident Mϕ. TGF-β is a key factor for M2 polarization of macrophages following IVD injury.
    Type of Medium: Online Resource
    ISSN: 0394-6320 , 2058-7384
    URL: Article
    DOI: 10.1177/03946320221103792
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
    detail.hit.zdb_id: 2505963-4
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  • 2
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    Hip-spine syndrome: cross-sectional-study of spinal alignment in patients with coxalgia
    SAGE Publications ; 2019
    In:  HIP International Vol. 29, No. 1 ( 2019-01), p. 21-25
    Details
    In: HIP International, SAGE Publications, Vol. 29, No. 1 ( 2019-01), p. 21-25
    Abstract: Patients presenting with hip diseases often have coexisting spine disorders, a condition that is termed “hip-spine syndrome.” However, few reports have evaluated total spinal alignments in patients with coxalgia. In this study, we retrospectively examined the relationship between several clinical and x-ray parameters of the hip joints and spinal alignment in patients with coxalgia. Methods: 100 patients with coxalgia (24 men, 76 women; average age, 60.0 years; age range, 16–88 years) were included. We retrospectively evaluated the following clinical and x-ray findings of hip joints and total spinal alignment: range of motion (ROM) and pain score components of the Japanese Orthopaedic Association Hip Score; leg length discrepancy (LLD); osteoarthritis (OA) stage of the hip; spinal coronal balance (Cobb angle and C7-central sacral ventral line [CSVL]); and spinal sagittal balance (sagittal vertical axis [SVA] , pelvic tilt (PT), and pelvic incidence [PI]). Results: Significant positive correlations were detected between C7 - CSVL and LLD ( r = 0.35), whereas a significant negative correlation was found between SVA and hip ROM score ( r = −0.37). A significant positive correlation was also detected between SVA and OA stage of the hip ( r = 0.35). Conclusion: In the present study, large leg length discrepancy and hip pain may contribute to spinal coronal misalignment. In addition, advanced stage of OA and decreasing ROM of the hip may lead to increased spinal sagittal misalignment. These findings suggest that when evaluating spinal alignment, the progression of OA, LLD, and pain and ROM of the hip joint should be assessed.
    Type of Medium: Online Resource
    ISSN: 1120-7000 , 1724-6067
    URL: Article
    DOI: 10.1177/1120700018803236
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2019
    detail.hit.zdb_id: 1475775-8
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  • 3
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    Relationship between synovial inflammatory cytokines and progression of osteoarthritis after hip arthroscopy: Experimental assessment
    SAGE Publications ; 2018
    In:  Journal of Orthopaedic Surgery Vol. 26, No. 2 ( 2018-05-01), p. 230949901877092-
    Details
    In: Journal of Orthopaedic Surgery, SAGE Publications, Vol. 26, No. 2 ( 2018-05-01), p. 230949901877092-
    Abstract: Synovial membrane inflammation is the most commonly presenting finding during hip arthroscopy and may have a role in the pathomechanism of hip osteoarthritis (OA). The aim of this study was to determine the relationship between synovial cytokine levels and progression of OA after hip arthroscopy. Methods: We prospectively examined 20 patients (20 hips) who underwent arthroscopic hip surgery. For all patients, radiographs and severity of pain were evaluated preoperatively. During arthroscopy, we harvested a sample of the synovial membrane and determined the levels of six typical inflammatory cytokines with real-time polymerase chain reaction. We compared the levels of these cytokines in patients who showed OA progression and non-progression after hip arthroscopy. Results: Although the average age of patients who showed OA progression postoperatively tended to be higher, there were no significant differences in characteristics involving clinical assessment between patients who showed OA progression and those who showed non-progression. Intraoperative tumour necrosis factor α (TNFα) expression was significantly higher in patients who showed OA progression postoperatively ( p = 0.042). Conclusions: Elevation of TNFα level might be a predictor of OA progression after hip arthroscopy.
    Type of Medium: Online Resource
    ISSN: 2309-4990 , 2309-4990
    URL: Article
    DOI: 10.1177/2309499018770922
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2018
    detail.hit.zdb_id: 2128854-9
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  • 4
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    Radiographic and Clinical Outcomes From the Use of S2 Alar Screws in Surgery for Adult Spinal Deformity
    SAGE Publications ; 2018
    In:  Global Spine Journal Vol. 8, No. 7 ( 2018-10), p. 668-675
    Details
    In: Global Spine Journal, SAGE Publications, Vol. 8, No. 7 ( 2018-10), p. 668-675
    Abstract: Retrospective. Objectives: To evaluate the efficacy of S2 alar screws in surgery for correction of adult spinal deformity (ASD). Methods: We retrospectively reviewed the cases of 23 patients (mean follow-up: 18.5 months, minimum 12 months) who underwent corrective surgery for ASD using S2 alar screws as anchors for instrumentation of lower vertebrae. The background of the patients and their spinopelvic parameters (pelvic incidence [PI], pelvic tilt [PT] , lumbar lordosis [LL], thoracic kyphosis [TK] , sagittal vertical axis [SVA], and PI-LL) were evaluated. Results: LL was improved from 9.7 ± 20.5° and SVA from 141.0 ± 64.0 mm before surgery to 39.0 ± 9.6° and 51.7 ± 40.8 mm immediately after surgery, respectively, and 38.2 ± 12.7° and 70.5 ± 59.2 mm at final follow-up. In 13 patients without sufficient correction (postoperative PI-LL ≥10°), bone mineral density and postoperative LL were significantly less, and PI, PI-LL, and PT were significantly greater than in patients with postoperative PI-LL 〈 10°, suggesting that these are risk factors for undercorrection. In 5 patients, SVA increased more than 40 mm during follow-up. Postoperative LL was significantly less (31.4° vs 41.0°) and postoperative PI-LL was significantly greater (21.6° vs 9.3°) in these patients, suggesting a PI-LL mismatch induces postoperative progression of global malalignment. Conclusions: Use of S2 alar screws as anchors for instrumentation in ASD surgery should be restricted. Their use might be an option for patients with low PI, and without severe osteoporosis, in whom efficient surgical correction can be obtained.
    Type of Medium: Online Resource
    ISSN: 2192-5682 , 2192-5690
    URL: Article
    DOI: 10.1177/2192568218762378
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2018
    detail.hit.zdb_id: 2648287-3
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  • 5
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    Somnolence and Dizziness During Mirogabalin Treatment in Patients With Neuropathic Pain Related to Lumbar Disease Who Switched From Pregabalin: A Retrospective Study
    SAGE Publications ; 2023
    In:  Global Spine Journal Vol. 13, No. 5 ( 2023-06), p. 1319-1324
    Details
    In: Global Spine Journal, SAGE Publications, Vol. 13, No. 5 ( 2023-06), p. 1319-1324
    Abstract: Multicenter retrospective study. Objectives: To investigate adverse events (AEs) in patients with neuropathic pain related to lumbar disease who switched to mirogabalin from pregabalin. Methods: This study surveyed the records of 82 patients with peripheral neuropathic leg pain related to lumbar disease who switched to mirogabalin from pregabalin. We evaluated AEs associated with pregabalin and mirogabalin, the continuation rate of mirogabalin, and the pain-relieving effect at 4 weeks after switching from pregabalin to mirogabalin. We compared patients who switched due to lack of efficacy (LoE group) and patients who switched due to AEs (AE group). Results: The incidence rates of somnolence and dizziness with pregabalin were 12.2% and 14.6%, respectively, while the incidence rates with mirogabalin were reduced to 7.3% for somnolence and 4.9% for dizziness. The incidence of AEs with pregabalin was significantly higher in the AE group (LoE group: 11.1%, AE group 100%), especially for somnolence (LoE group: 3.2%, AE group: 47.1%) and dizziness (LoE group: 4.8%, AE: 52.9%). After switching, the incidences of AEs with mirogabalin were not significantly different between the 2 groups (LoE group: 15.9%, AE group: 23.5%), including for somnolence (LoE group: 7.9%, AE group: 5.9%) and dizziness (LoE group: 4.8%, AE group: 5.9%). There were no significant differences in continuation rate of mirogabalin or the pain-relieving effect between groups. Conclusions: The patients who experience somnolence and dizziness with pregabalin might be able to continue safely receiving treatment for their pain by switching to mirogabalin.
    Type of Medium: Online Resource
    ISSN: 2192-5682 , 2192-5690
    URL: Article
    DOI: 10.1177/21925682211031185
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2023
    detail.hit.zdb_id: 2648287-3
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  • 6
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    Occupational Characteristics of Low Back Pain Among Standing Workers in a Japanese Manufacturing Company
    SAGE Publications ; 2020
    In:  Workplace Health & Safety Vol. 68, No. 1 ( 2020-01), p. 13-23
    Details
    In: Workplace Health & Safety, SAGE Publications, Vol. 68, No. 1 ( 2020-01), p. 13-23
    Abstract: Low back pain (LBP) is a major public health problem that adversely affects the quality of life (QOL) of workers. The etiology of LBP is considered to be multi-factorial with individual, physical, and psychosocial factors contributing to its development and persistence. Although prevention of LBP in workers in the workplace is very important, only a small number of studies have assessed the risk factors and epidemiology of LBP among Japanese factory workers who stand as part of their job. This cross-sectional study investigated the prevalence of LBP in 691 factory employees who conducted their work while standing. Health-related QOL was evaluated using the Roland-Morris Disability Questionnaire (RDQ) to quantify the severity of LBP with the aim of identifying risk factors for LBP among workers who stand as part of their work in an electronics manufacturing company. We observed that the prevalence of LBP lasting for at least 48 hours within a week was 20.0% among participants, with female employees and those with a prior history of LBP having a significantly increased risk of developing LBP. The distribution of the RDQ score showed a negative regression curve among the employees, which was different from the normal distribution pattern reported previously in Japanese patients with LBP. These findings suggest that prolonged standing among factory workers poses an increased risk for LBP.
    Type of Medium: Online Resource
    ISSN: 2165-0799 , 2165-0969
    URL: Article
    DOI: 10.1177/2165079919853839
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2020
    detail.hit.zdb_id: 2649522-3
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