In:
Journal of Applied Toxicology, Wiley, Vol. 41, No. 7 ( 2021-07), p. 1021-1037
Abstract:
Hippocampal dentate gyrus of rat offspring exposed maternally to PTU, VPA, or GLY was subjected to global methylation analysis on PND 21. Genes downregulated on PND 77 were examined. PTU concurrently downregulated Creb , Arc , and Hes5 , suggesting an association with the diverse effects on neurogenesis. PTU also concurrently downregulated Epha7 and Pvalb , suggesting an association with progenitor cell reduction. VPA downregulated Vgf and Dpysl4 , suggesting an association with the aberrant synaptic plasticity. In contrast, GLY did not induce sustained downregulation.
Type of Medium:
Online Resource
ISSN:
0260-437X
,
1099-1263
Language:
English
Publisher:
Wiley
Publication Date:
2021
detail.hit.zdb_id:
1475015-6
Permalink