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  • Takada, Sanae  (4)
  • 1995-1999  (4)
Material
Publisher
Person/Organisation
Language
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  • 1995-1999  (4)
Year
  • 1
    Online Resource
    Online Resource
    Bleomycin-induced inflammation in synovial membrane and periarticular tissue of rats
    Elsevier BV ; 1996
    In:  Toxicology Letters Vol. 88 ( 1996-10), p. 98-
    Details
    In: Toxicology Letters, Elsevier BV, Vol. 88 ( 1996-10), p. 98-
    Type of Medium: Online Resource
    ISSN: 0378-4274
    URL: Article
    DOI: 10.1016/S0378-4274(96)80355-9
    Language: English
    Publisher: Elsevier BV
    Publication Date: 1996
    detail.hit.zdb_id: 1500784-4
    SSG: 12
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    Online Resource
  • 2
    Online Resource
    Online Resource
    Histological Examination on Achilles Tendon Lesions Induced by Quinolone Antibacterial Agents in Juvenile Rats
    SAGE Publications ; 1995
    In:  Toxicologic Pathology Vol. 23, No. 3 ( 1995-05), p. 385-392
    Details
    In: Toxicologic Pathology, SAGE Publications, Vol. 23, No. 3 ( 1995-05), p. 385-392
    Abstract: We examined the effects of the quinolone antibacterial agents pefloxacin (PFLX) and ofloxacin (OFLX) on the Achilles tendon of Sprague-Dawley rats. A single oral administration of PFLX 300 and 900 mg/kg or OFLX 900 mg/kg induced edema with mononuclear cell infiltration mainly in the inner sheath of the inner Achilles tendon just proximal to the tuber calcanei in rats killed on the next day. Cell infiltration was also seen in the adjacent synovial membrane and joint space. With progression of severity, the lesions extended to the surface tendon tissue, wherein irregularly arranged collagen bundles were detached from each other and nuclei of fibroblasts were pyknotic and fragmented. After 2-wk repeated administration, these lesions were replaced by fibrotic foci with regenerated tendon fibroblasts, and the incidence and severity were reduced in the OFLX but not PFLX groups. Coadministration of cyclosporin A with OFLX 300 mg/ kg induced these lesions despite the fact that neither induced lesions alone. The tendon lesions were induced in juvenile rats (4 wk of age) but not in young adults (12 wk). The articular cartilage of juvenile rats showed focal degeneration and/or cavitation in the tarsal joints after a single and 2-wk administration of PFLX or OFLX. Hydrocortisone slightly increased the incidence of OFLX-induced lesions in both the tendon and cartilage after a 2-wk administration. The occurrence of the tendon lesions is different from that of the Achilles tendon disorders reported in older humans, but they are thought to be a useful model for them.
    Type of Medium: Online Resource
    ISSN: 0192-6233 , 1533-1601
    URL: Article
    DOI: 10.1177/019262339502300315
    Language: English
    Publisher: SAGE Publications
    Publication Date: 1995
    detail.hit.zdb_id: 2056753-4
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  • 3
    Online Resource
    Online Resource
    Bleomycin-Induced Arthritis and Dermatitis in Rats
    SAGE Publications ; 1997
    In:  Toxicologic Pathology Vol. 25, No. 6 ( 1997-11), p. 549-555
    Details
    In: Toxicologic Pathology, SAGE Publications, Vol. 25, No. 6 ( 1997-11), p. 549-555
    Abstract: We investigated the effect of the antitumor drug bleomycin (BLM) on synovial membrane and periarticular deep dermis in 10-wk-old young adult rats. BLM was found to induce edema, mononuclear cell infiltration and necrosis of the synovial membrane in the knee and tarsal joint, and inflammation in the deep dermis of the plantar hindfoot and digital pulvini in these rats after subcutaneous administration of 20 mg/kg for 3 days. After a 4-wk recovery period, foci of degenerative collagen bundles were observed in the deep dermis of the plantar hindfoot in spite of complete recovery of the lesions in the other dermal and synovial membrane sites. The synovitis was determined to begin with vesiculation of the macrophage-type lining cells, followed by edema and cell infiltration, especially near ligament insertion sites in the knee joint. The early dermal lesion consisted of dissociation of endothelial and subendothelial cells in small blood vessels thought to be postcapillary venules, edema, and monocyte infiltration. The severity of arthritis was greater in young adults than juvenile rats. From these results, BLM was shown to have a toxic effect on synovial lining cells and to induce inflammation in the synovial membrane and periarticular dermis.
    Type of Medium: Online Resource
    ISSN: 0192-6233 , 1533-1601
    URL: Article
    DOI: 10.1177/019262339702500603
    Language: English
    Publisher: SAGE Publications
    Publication Date: 1997
    detail.hit.zdb_id: 2056753-4
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  • 4
    Online Resource
    Online Resource
    Inflammatory cytokine production induced by an analogue of muramyl dipeptide MDP-Lys(L18) in rat macrophage cultures and dog synovial fluid
    Springer Science and Business Media LLC ; 1996
    In:  Inflammation Vol. 20, No. 1 ( 1996-2), p. 43-56
    Details
    In: Inflammation, Springer Science and Business Media LLC, Vol. 20, No. 1 ( 1996-2), p. 43-56
    Type of Medium: Online Resource
    ISSN: 0360-3997 , 1573-2576
    URL: Article
    DOI: 10.1007/BF01487744
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 1996
    detail.hit.zdb_id: 2015610-8
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