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  • 1
    Online Resource
    Online Resource
    Perception–Action Integration Is Altered in Functional Movement Disorders
    Wiley ; 2023
    In:  Movement Disorders Vol. 38, No. 8 ( 2023-08), p. 1399-1409
    Details
    In: Movement Disorders, Wiley, Vol. 38, No. 8 ( 2023-08), p. 1399-1409
    Abstract: Although functional neurological movement disorders (FMD) are characterized by motor symptoms, sensory processing has also been shown to be disturbed. However, how the integration of perception and motor processes, essential for the control of goal‐directed behavior, is altered in patients with FMD is less clear. A detailed investigation of these processes is crucial to foster a better understanding of the pathophysiology of FMD and can systematically be achieved in the framework of the theory of event coding (TEC). Objective The aim was to investigate perception–action integration processes on a behavioral and neurophysiological level in patients with FMD. Methods A total of 21 patients and 21 controls were investigated with a TEC‐related task, including concomitant electroencephalogram (EEG) recording. We focused on EEG correlates established to reflect perception–action integration processes. Temporal decomposition allowed to distinguish between EEG codes reflecting sensory (S‐cluster), motor (R‐cluster), and integrated sensory–motor processing (C‐cluster). We also applied source localization analyses. Results Behaviorally, patients revealed stronger binding between perception and action, as evidenced by difficulties in reconfiguring previously established stimulus–response associations. Such hyperbinding was paralleled by a modulation of neuronal activity clusters, including reduced C‐cluster modulations of the inferior parietal cortex and altered R‐cluster modulations in the inferior frontal gyrus. Correlations of these modulations with symptom severity were also evident. Conclusions Our study shows that FMD is characterized by altered integration of sensory information with motor processes. Relations between clinical severity and both behavioral performance and neurophysiological abnormalities indicate that perception–action integration processes are central and a promising concept for the understanding of FMD. © 2023 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
    Type of Medium: Online Resource
    ISSN: 0885-3185 , 1531-8257
    URL: Issue
    URL: Article
    DOI: 10.1002/mds.v38.8
    DOI: 10.1002/mds.29458
    RVK:
    XA 10000
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2041249-6
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  • 2
    Online Resource
    Online Resource
    Processing of embedded response plans is modulated by an interplay of frontoparietal theta and beta activity
    American Physiological Society ; 2022
    In:  Journal of Neurophysiology Vol. 128, No. 3 ( 2022-09-01), p. 543-555
    Details
    In: Journal of Neurophysiology, American Physiological Society, Vol. 128, No. 3 ( 2022-09-01), p. 543-555
    Abstract: Even simple actions like opening a door require integration/binding and flexible reactivation of different motor elements. Yet, the neural mechanisms underlying the processing of such “embedded response plans” are largely elusive, despite theoretical frameworks, such as the theory of event coding, describing the involved cognitive processes. In a sample of n = 40 healthy participants, we combine time-frequency decomposition and various beamforming methods to examine the neurophysiological dynamics of such action plans, with special emphasis on the interplay of theta and beta frequency activity during the processing of these plans. We show that the integration and rule-guided reactivation of embedded response plans is modulated by a complex interplay of theta and beta activity. Pretrial beta-band activity (BBA) is related to different functional neuroanatomical structures that are activated in a consecutive fashion. Enhanced preparatory activity is positively associated with higher binding-related BBA in the precuneus/parietal areas, indicating that activity in the precuneus/parietal cortex facilitates the execution of an embedded action sequence. Increased preparation subsequently leads to reduced working memory retrieval demands. A cascading pattern of interactions between pretrial and within-trial activity indicates the importance of preparatory brain activity. The study shows that there are multiple roles of beta and theta oscillations associated with different functional neuroanatomical structures during the integration and reactivation of motor elements during actions. NEW & NOTEWORTHY Even simple actions like opening a door require integration/binding and flexible reactivation of different motor elements. Yet, the neural mechanisms underlying the processing of such “embedded response plans” are largely elusive. The study shows that there are multiple roles of beta and theta oscillations associated with different functional neuroanatomical structures during the integration and reactivation of motor elements during actions.
    Type of Medium: Online Resource
    ISSN: 0022-3077 , 1522-1598
    URL: Article
    DOI: 10.1152/jn.00537.2021
    RVK:
    XA 10000 ; XA 552555
    Language: English
    Publisher: American Physiological Society
    Publication Date: 2022
    detail.hit.zdb_id: 80161-6
    detail.hit.zdb_id: 1467889-5
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  • 3
    Online Resource
    Online Resource
    Increased perception-action binding in Tourette syndrome
    Oxford University Press (OUP) ; 2020
    In:  Brain Vol. 143, No. 6 ( 2020-06-01), p. 1934-1945
    Details
    In: Brain, Oxford University Press (OUP), Vol. 143, No. 6 ( 2020-06-01), p. 1934-1945
    Abstract: Gilles de la Tourette syndrome is a multifaceted neurodevelopmental disorder characterized by multiple motor and vocal tics. Research in Tourette syndrome has traditionally focused on the motor system. However, there is increasing evidence that perceptual and cognitive processes play a crucial role as well. Against this background it has been reasoned that processes linking perception and action might be particularly affected in these patients with the strength of perception-action binding being increased. However, this has not yet been studied experimentally. Here, we investigated adult Tourette patients within the framework of the ‘Theory of Event Coding’ using an experimental approach allowing us to directly test the strength of perception-action binding. We included 24 adult patients with Tourette syndrome and n = 24 healthy control subjects using a previously established visual-motor event file task with four levels of feature overlap requiring repeating or alternating responses. Concomitant to behavioural testing, EEG was recorded and analysed using temporal signal decomposition and source localization methods. On a behavioural level, perception-action binding was increased in Tourette patients. Tic frequency correlated with performance in conditions where unbinding processes of previously established perception-action bindings were required with higher tic frequency being associated with stronger perception-action binding. This suggests that perception-action binding is intimately related to the occurrence of tics. Analysis of EEG data showed that behavioural changes cannot be explained based on simple perceptual or motor processes. Instead, cognitive processes linking perception to action in inferior parietal cortices are crucial. Our findings suggest that motor or sensory processes alone are less relevant for the understanding of Tourette syndrome than cognitive processes engaged in linking and restructuring of perception-action association. A broader cognitive framework encompassing perception and action appears well suited to opening new routes for the understanding of Tourette syndrome.
    Type of Medium: Online Resource
    ISSN: 0006-8950 , 1460-2156
    URL: Article
    DOI: 10.1093/brain/awaa111
    RVK:
    XA 10000
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2020
    detail.hit.zdb_id: 1474117-9
    SSG: 12
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  • 4
    Online Resource
    Online Resource
    Neurophysiology of embedded response plans: age effects in action execution but not in feature integration from preadolescence to adulthood
    American Physiological Society ; 2021
    In:  Journal of Neurophysiology Vol. 125, No. 4 ( 2021-04-01), p. 1382-1395
    Details
    In: Journal of Neurophysiology, American Physiological Society, Vol. 125, No. 4 ( 2021-04-01), p. 1382-1395
    Abstract: Performing a goal-directed movement consists of a chain of complex preparatory mechanisms. Such planning especially requires integration (or binding) of various action features, a process that has been conceptualized in the “theory of event coding.” Theoretical considerations and empirical research suggest that these processes are subject to developmental effects from adolescence to adulthood. The aim of the present study was to investigate age-related modulations in action feature binding processes and to shed light on underlying neurophysiological development from preadolescence to early adulthood. We examined a group of healthy participants ( n = 61) between 10 and 30 yr of age, who performed a task that requires a series of bimanual response selections in an embedded paradigm. For an in-depth analysis of the underlying neural correlates, we applied EEG signal decomposition together with source localization analyses. Behavioral results across the whole group did not show binding effects in reaction times but in intraindividual response variability. From age 10 to 30 yr, there was a decrease in reaction times and reaction time variability but no age-related effect in action file binding. The latter were corroborated by Bayesian data analyses. On the brain level, the developmental effects on response selection were associated with activation modulations in the superior parietal cortex (BA7). The results show that mechanisms of action execution and speed, but not those of action feature binding, are subject to age-related changes between the age of 10 and 30 yr. NEW & NOTEWORTHY Different aspects of an action need to be integrated to allow smooth unfolding of behavior. We examine developmental effects in these processes and show that mechanisms of action execution and speed, but not those of action feature binding, are subject to age-related changes between the age of 10 and 30 yr.
    Type of Medium: Online Resource
    ISSN: 0022-3077 , 1522-1598
    URL: Article
    DOI: 10.1152/jn.00681.2020
    RVK:
    XA 10000 ; XA 552555
    Language: English
    Publisher: American Physiological Society
    Publication Date: 2021
    detail.hit.zdb_id: 80161-6
    detail.hit.zdb_id: 1467889-5
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