In:
Chemistry – A European Journal, Wiley, Vol. 10, No. 19 ( 2004-10-04), p. 4894-4909
Abstract:
Gambierol is a polycyclic ether toxin, which has been isolated from the marine dinoflagellate Gambierdiscus toxicus . A series of gambierol analogues have been prepared from an advanced intermediate of our total synthesis of gambierol and investigated for their toxicity against mice, thus providing the first systematic structure–activity relationships (SAR) of this polycyclic ether class of marine toxin. The SAR studies described herein clearly indicate that 1) the C28C29 double bond within the H ring and the unsaturated side chain are the crucial structural elements required for exerting potent biological activity and 2) the C1 and C6 hydroxy groups, the C30 methyl group, and the C37C38 double bond have little influence on the degree of neurotoxicity against mice.
Type of Medium:
Online Resource
ISSN:
0947-6539
,
1521-3765
DOI:
10.1002/chem.200400355
Language:
English
Publisher:
Wiley
Publication Date:
2004
detail.hit.zdb_id:
1478547-X
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