In:
Pediatric Anesthesia, Wiley, Vol. 27, No. 3 ( 2017-03), p. 290-299
Abstract:
Rett syndrome is associated with severe motor and communicative impairment making optimal postoperative pain management a challenge. There are case reports documenting reduced postoperative analgesic requirement in Rett syndrome. Aim The goal of this preliminary investigation was to compare postoperative analgesic management among a sample of girls with Rett syndrome compared to girls with and without developmental disability undergoing spinal fusion surgery. Method The medical records of eight girls with Rett syndrome (mean age = 13.2 years, sd = 1.9), eight girls with developmental disability (cerebral palsy; mean age = 13.1 years, sd = 2.0), and eight girls without developmental disability (adolescent idiopathic scoliosis; mean age = 13.4, sd = 1.8) were reviewed. Data related to demographics, medications, and route of drug administration were recorded. Results Girls with Rett syndrome received significantly fewer morphine equivalent opioids postoperatively ( M = 0.26 mg·kg −1 ·day −1 , sd = 0.10) compared to girls with adolescent idiopathic scoliosis ( M = 0.47mg·kg −1 ·day −1 , sd = 0.13; 95% CI −0.34 to −0.08; P = 0.001) and girls with CP ( M = 0.40 mg·kg −1 per day, sd = 0.14; 95% CI −0.27 to −0.02; P = 0.01). Girls with Rett syndrome received significantly fewer opioid patient‐controlled analgesic ( PCA ) bolus doses (given by proxy; M = 42.63, sd = 17.84) compared to girls with adolescent idiopathic scoliosis ( M = 98.25, sd = 52.77; 95% CI −96.42 to −14.83; P = 0.01). There was also some evidence indicating girls with Rett syndrome received fewer bolus doses compared to girls with CP ( M = 80.88, sd = 38.93; 95% CI −79.05 to 2.55; P = 0.06). On average, girls with Rett syndrome also received smaller total doses of acetaminophen, diazepam, and hydroxyzine. Conclusion This study highlights possible discrepancies in postoperative pain management specific to girls with Rett syndrome and suggests further investigation is warranted to determine best practice for postoperative analgesic management for this vulnerable patient population.
Type of Medium:
Online Resource
ISSN:
1155-5645
,
1460-9592
DOI:
10.1111/pan.2017.27.issue-3
Language:
English
Publisher:
Wiley
Publication Date:
2017
detail.hit.zdb_id:
2008564-3
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