In:
FEBS Letters, Wiley, Vol. 205, No. 2 ( 1986-09-15), p. 313-317
Abstract:
The complete amino acid sequence of the large subunit (catalytic subunit) of human low‐Ca 2+ requiring‐calcium‐activated neutral protease (μCANP) was deduced from its cDNA base sequence. It is composed of 714 amino acid residues and its sequence is highly homologous to the chicken CANP sequence determined previously. Human μCANP, like chicken CANP, has a clear 4‐domain structure, and their fundamental structures are essentially the same, although their Ca 2+ sensitivities are significantly different. The role of each domain in the Ca 2+ sensitivity and protease activity of CANP is discussed on the basis of sequence comparison.
Type of Medium:
Online Resource
ISSN:
0014-5793
,
1873-3468
DOI:
10.1016/0014-5793(86)80919-X
Language:
English
Publisher:
Wiley
Publication Date:
1986
detail.hit.zdb_id:
1460391-3
SSG:
12
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