In:
Medical Physics, Wiley, Vol. 38, No. 4 ( 2011-04), p. 2045-2052
Abstract:
The authors compare two electron paramagnetic resonance imaging modalities at 250 MHz to determine advantages and disadvantages of those modalities for in vivo oxygen imaging. Methods: Electron spin echo (ESE) and continuous wave (CW) methodologies were used to obtain three‐dimensional images of a narrow linewidth, water soluble, nontoxic oxygen‐sensitive trityl molecule OX063 in vitro and in vivo . The authors also examined sequential images obtained from the same animal injected intravenously with trityl spin probe to determine temporal stability of methodologies. Results: A study of phantoms with different oxygen concentrations revealed a threefold advantage of the ESE methodology in terms of reduced imaging time and more precise oxygen resolution for samples with less than 70 torr oxygen partial pressure. Above , CW performed better. The images produced by both methodologies showed distributions with similar mean values. However, ESE images demonstrated superior performance in low regions while missing voxels in high regions. Conclusions: ESE and CW have different areas of applicability. ESE is superior for hypoxia studies in tumors.
Type of Medium:
Online Resource
ISSN:
0094-2405
,
2473-4209
Language:
English
Publisher:
Wiley
Publication Date:
2011
detail.hit.zdb_id:
1466421-5
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