In:
Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics, Computers, Materials and Continua (Tech Science Press), Vol. 22, No. 4 ( 2015-09-15), p. 203-211
Abstract:
Liver cancer is one of the most lethal cancers, but our knowledge of the molecular mechanism underlying this process remains insufficient. Through deep sequencing and expression regulation analysis in liver cancer cells, we identified two novel factors, AKR1C2 (positive factor) and
NF1 (negative factor), as the AEG-1 downstream players in the process of metastasis in liver cancer. They were experimentally validated to have the capacities of regulating cell migration, cell invasion, cell proliferation, and EMT. Further clinic expression and animal model evidence confirmed their functions. Together, our findings provide a new insight into the pharmaceutical and therapeutic use of AEG-1 and downstream AKR1C2 and NF1.
Type of Medium:
Online Resource
ISSN:
0965-0407
DOI:
10.3727/096504015X14386062091352
Language:
English
Publisher:
Computers, Materials and Continua (Tech Science Press)
Publication Date:
2015
detail.hit.zdb_id:
1114699-0
detail.hit.zdb_id:
2044620-2
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