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  • 1
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    Online Resource
    Effects of physical activity on lung function and quality of life in asthmatic children: An updated systematic review and meta-analysis
    Frontiers Media SA ; 2023
    In:  Frontiers in Pediatrics Vol. 11 ( 2023-2-8)
    Details
    In: Frontiers in Pediatrics, Frontiers Media SA, Vol. 11 ( 2023-2-8)
    Abstract: The benefits of physical activity (PA) for asthmatic children were increasingly recognized, and as the design of studies on PA and asthma has become more refined in recent years, the latest evidence needed to be updated. We performed this meta-analysis to synthesize the evidence available from the last 10 years to update the effects of PA in asthmatic children. Methods A systematic search was conducted in three databases, PubMed, Web of Science, and Cochrane Library. Randomized controlled trials were included, and two reviewers independently conducted the inclusion screening, data extraction, and bias assessment. Results A total of 9 studies were included in this review after 3,919 articles screened. PA significantly improved the forced vital capacity (FVC) (MD 7.62; 95% CI: 3.46 to 11.78; p   & lt; 0.001), and forced expiratory flow between 25% and 75% of forced vital capacity (FEF 25–75 ) (MD 10.39; 95% CI: 2.96 to 17.82; p  = 0.006) in lung function. There was no significant difference in forced expiratory volume in the first second (FEV 1 ) (MD 3.17; 95% CI: −2.82 to 9.15; p  = 0.30) and fractional exhaled nitric oxide (FeNO) (MD −1.74; 95% CI: −11.36 to 7.88; p  = 0.72). Also, PA significantly improved the quality of life as assessed by the Pediatric Asthma Quality of Life Questionnaire (all items p   & lt; 0.05). Conclusions This review suggested that PA could improve FVC, FEF 25–75 , and quality of life in asthmatic children, but there was insufficient evidence of improvement in FEV 1 and airway inflammation. Systematic Review Registration https://www.crd.york.ac.uk/PROSPERO/ , identifier: CRD42022338984.
    Type of Medium: Online Resource
    ISSN: 2296-2360
    URL: Article
    DOI: 10.3389/fped.2023.1074429
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2023
    detail.hit.zdb_id: 2711999-3
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  • 2
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    Table_4.DOCX
    Frontiers Media SA ; 2023
    In:  Frontiers in Microbiology Vol. 14 ( 2023-7-25)
    Details
    In: Frontiers in Microbiology, Frontiers Media SA, Vol. 14 ( 2023-7-25)
    Abstract: Previous studies have found that unique patterns of gut microbial colonization in infancy associated with the development of allergic diseases. However, there is no research on the gut microbiota characteristics of AR children in Chinese Mainland. Objective To investigate the changes of gut microbial of AR children in Chinese Mainland and evaluate the correlation between gut microbial and clinical indexes. Methods In this clinical study, fecal samples from 24 AR children and 25 healthy control children (HCs) were comparative via next generation sequencing of the V3-V4 regions of the 16S rRNA gene. Analyzed the relationship between clinical features and gut microbial using Spearman correlation. Results Compared to HCs, AR children showed significant decreases in Shannon index and significant increases in Simpson index at both the family and genera levels (all p & lt; 0.05). In terms of bacterial composition, at the phylum level, AR children had higher abundance of Bacteroidetes than that in the HCs group ( p & lt; 0.05) and were significantly positively correlated with TNSS ( p & lt; 0.05). At the family level, AR children had higher abundance of Prevotellaceae and Enterobacteriaceae higher than that in the HCs group (all p & lt; 0.05) and had a significantly positive correlation with TNSS, eosinophils (EOS) and total immunoglobulin E (tIgE) (all p & lt; 0.05). At the genus level, reduced abundance of Agathobacter, Parasutterella, Roseburia and Subdoligranulum were also observed in the AR cohorts compared to HCs (all p & lt; 0.05) and significantly negatively associated with TNSS, EOS, tIgE, QOL, and FeNO (all p & lt; 0.05). Conclusion AR children in Chinese Mainland were characterized by reduced microbial diversity and distinguished microbial characteristics in comparison with HCs. The observations of this study offer proof that distinctive gut microbiota profiles were present in AR children and necessitate further investigation in the form of mechanistic studies.
    Type of Medium: Online Resource
    ISSN: 1664-302X
    URL: Article
    URL: Article
    URL: Article
    URL: Article
    URL: Article
    DOI: 10.3389/fmicb.2023.1208816
    DOI: 10.3389/fmicb.2023.1208816.s001
    DOI: 10.3389/fmicb.2023.1208816.s002
    DOI: 10.3389/fmicb.2023.1208816.s003
    DOI: 10.3389/fmicb.2023.1208816.s004
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2023
    detail.hit.zdb_id: 2587354-4
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  • 3
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    Network Embedding via Deep Prediction Model
    Institute of Electrical and Electronics Engineers (IEEE) ; 2023
    In:  IEEE Transactions on Big Data Vol. 9, No. 2 ( 2023-4-1), p. 455-470
    Details
    In: IEEE Transactions on Big Data, Institute of Electrical and Electronics Engineers (IEEE), Vol. 9, No. 2 ( 2023-4-1), p. 455-470
    Type of Medium: Online Resource
    ISSN: 2332-7790 , 2372-2096
    URL: Article
    DOI: 10.1109/TBDATA.2022.3194643
    Language: Unknown
    Publisher: Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2023
    detail.hit.zdb_id: 2833659-8
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  • 4
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    Efficacy and safety of house dust mite subcutaneous immunotherapy in polysensitized children with allergic asthma
    Elsevier BV ; 2023
    In:  Pulmonary Pharmacology & Therapeutics Vol. 78 ( 2023-02), p. 102187-
    Details
    In: Pulmonary Pharmacology & Therapeutics, Elsevier BV, Vol. 78 ( 2023-02), p. 102187-
    Type of Medium: Online Resource
    ISSN: 1094-5539
    URL: Article
    DOI: 10.1016/j.pupt.2022.102187
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2023
    detail.hit.zdb_id: 1471690-2
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  • 5
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    Effect of Probiotics on Respiratory Tract Allergic Disease and Gut Microbiota
    Frontiers Media SA ; 2022
    In:  Frontiers in Nutrition Vol. 9 ( 2022-2-22)
    Details
    In: Frontiers in Nutrition, Frontiers Media SA, Vol. 9 ( 2022-2-22)
    Abstract: Allergy is a hypersensitivity reaction triggered by specific cell or antibody-mediated immune mechanisms. Allergies have increased in industrialized countries in recent decades. The rise in allergic respiratory diseases such as allergic rhinitis (AR) and allergic asthma (AA) is a potential threat to public health. Searches were conducted using PubMed, Google Scholar and Medline using the following key terms: allergic rhinitis OR asthma AND probiotics, allergic airway inflammation AND immune disorders, probiotics OR gut microbiota AND allergic disease, probiotics AND inflammatory. Studies from all years were included, specifically those published within the last 10 years. Some review articles and their reference lists were searched to identify related articles. The role of microbiota in respiratory allergic diseases has attracted more and more attention. Pieces of evidence suggested that the development of allergic diseases causes a possible imbalance in the composition of the gut microbiota. Compared to colonized mice, germ-free mice exhibit exaggerated allergic airway responses, suggesting that microbial host interactions play an important role in the development of allergic diseases. Probiotics modulate both the innate and adaptive inflammatory immune responses, often used as dietary supplements to provide health benefits in gastrointestinal disorders. Probiotics may serve as immunomodulators and activators of host defense pathways. Besides, oral probiotics can modulate the immune response in the respiratory system. Recently, studies in humans and animals have demonstrated the role of probiotic in RA and AA. To understand the characterization, microbiota, and the potential role of probiotics intervention of AA/AR, this review provides an overview of clinical features of AA and AR, probiotics for the prevention and treatment of AR, AA, changes in gut microbiota, and their mechanisms of action.
    Type of Medium: Online Resource
    ISSN: 2296-861X
    URL: Article
    DOI: 10.3389/fnut.2022.821900
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2022
    detail.hit.zdb_id: 2776676-7
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  • 6
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    Network Structure and Transfer Behaviors Embedding via Deep Prediction Model
    Association for the Advancement of Artificial Intelligence (AAAI) ; 2019
    In:  Proceedings of the AAAI Conference on Artificial Intelligence Vol. 33, No. 01 ( 2019-07-17), p. 5041-5048
    Details
    In: Proceedings of the AAAI Conference on Artificial Intelligence, Association for the Advancement of Artificial Intelligence (AAAI), Vol. 33, No. 01 ( 2019-07-17), p. 5041-5048
    Abstract: Network-structured data is becoming increasingly popular in many applications. However, these data present great challenges to feature engineering due to its high non-linearity and sparsity. The issue on how to transfer the link-connected nodes of the huge network into feature representations is critical. As basic properties of the real-world networks, the local and global structure can be reflected by dynamical transfer behaviors from node to node. In this work, we propose a deep embedding framework to preserve the transfer possibilities among the network nodes. We first suggest a degree-weight biased random walk model to capture the transfer behaviors of the network. Then a deep embedding framework is introduced to preserve the transfer possibilities among the nodes. A network structure embedding layer is added into the conventional Long Short-Term Memory Network to utilize its sequence prediction ability. To keep the local network neighborhood, we further perform a Laplacian supervised space optimization on the embedding feature representations. Experimental studies are conducted on various real-world datasets including social networks and citation networks. The results show that the learned representations can be effectively used as features in a variety of tasks, such as clustering, visualization and classification, and achieve promising performance compared with state-of-the-art models.
    Type of Medium: Online Resource
    ISSN: 2374-3468 , 2159-5399
    URL: Article
    DOI: 10.1609/aaai.v33i01.33015041
    Language: Unknown
    Publisher: Association for the Advancement of Artificial Intelligence (AAAI)
    Publication Date: 2019
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  • 7
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    Efficacy and Safety of House Dust Mite Subcutaneous Immunotherapy in Polysensitized Children with Allergic Asthma
    Elsevier BV ; 2022
    In:  SSRN Electronic Journal
    Details
    In: SSRN Electronic Journal, Elsevier BV
    Type of Medium: Online Resource
    ISSN: 1556-5068
    URL: Article
    DOI: 10.2139/ssrn.4249980
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2022
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  • 8
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    Efecto de los probióticos en las enfermedades alérgicas del tracto respiratorio y la microbiota intestinal
    S. Karger AG ; 2022
    In:  Kompass Neumología Vol. 4, No. 2 ( 2022), p. 81-91
    Details
    In: Kompass Neumología, S. Karger AG, Vol. 4, No. 2 ( 2022), p. 81-91
    Abstract: La alergia es una reacción de hipersensibilidad activada por mecanismos inmunitarios específicos mediados por células o anticuerpos. Las alergias han aumentado en los países industrializados durante las últimas décadas. El aumento de las enfermedades respiratorias alérgicas, como la rinitis alérgica (RA) y el asma alérgica (AA), es una amenaza potencial para la salud pública. Se realizaron búsquedas en PubMed, Google Scholar y Medline utilizando los siguientes términos clave: allergic rhinitis OR asthma AND probiotics, allergic airway inflammation AND immune disorders, probiotics OR gut microbiota AND allergic disease, probiotics AND inflammatory. Se incluyeron estudios de todos los años, específicamente aquellos publicados en los últimos diez años. Se buscó en algunos artículos de revisión y en su lista de referencias para identificar artículos relacionados. El papel de la microbiota en las enfermedades alérgicas respiratorias ha atraído cada vez más atención. Algunas pruebas sugieren que el desarrollo de las enfermedades alérgicas provoca un desequilibrio en la composición de la microbiota intestinal. En comparación con ratones colonizados, los ratones sin gérmenes presentan respuestas alérgicas exageradas en las vías respiratorias, lo que indica que las interacciones microbianas con el huésped tienen un papel importante en el desarrollo de las enfermedades alérgicas. Los probióticos modulan tanto la respuesta inmune innata como la adaptativa, y a menudo se emplean como suplementos dietéticos que aportan beneficios a la salud en los trastornos gastrointestinales. Los probióticos pueden actuar como inmunomoduladores y activadores de las vías de defensa del huésped. Asimismo, los probióticos orales pueden modular la respuesta inmune en el sistema respiratorio. Estudios recientes en humanos y animales han demostrado el papel de los probióticos en la RA y la AA. Para entender la caracterización de la microbiota y el efecto potencial de los probióticos en la AA/AR, esta revisión ofrece un panorama de las características clínicas de la AA y la RA y del uso de probióticos para la prevención y el tratamiento de la RA, los cambios en la microbiota intestinal y sus mecanismos de acción.
    Type of Medium: Online Resource
    ISSN: 2624-9065 , 2624-9073
    URL: Article
    DOI: 10.1159/000525449
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2022
    detail.hit.zdb_id: 2986459-8
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