In:
Neuroimmunomodulation, S. Karger AG, Vol. 23, No. 5-6 ( 2016), p. 352-358
Abstract:
〈 b 〉 〈 i 〉 Objective: 〈 /i 〉 〈 /b 〉 To screen cytokines and chemokines and determine their dynamic changes in the serum and cerebrospinal fluid (CSF) of patients with neuromyelitis optica spectrum disorder (NMOSD). 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 Eight NMOSD with seropositive aquaporin-4 antibody (AQP4-IgG) were enrolled, as well as 8 matched patients with multiple sclerosis (MS) and 8 with noninflammatory neurological diseases, who were included as controls. In total, 102 cytokines and 34 chemokines were detected in the CSF and serum of NMOSD patients and controls. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 CSF interleukin (IL)-17A levels were significantly higher in NMOSD patients in the relapsing phase (27.15 ± 11.33) than in those in the remitting phase (10.04 ± 3.11, 〈 i 〉 p 〈 /i 〉 = 0.0017), and patients with MS (14.72 ± 3.20, 〈 i 〉 p 〈 /i 〉 = 0.0283) and other controls (10.39 ± 11.38, 〈 i 〉 p 〈 /i 〉 = 0.0021). CSF IL-6 levels were higher in the NMOSD patients in the relapsing phase (12.23 ± 3.47) than in those in the remitting phase (5.87 ± 2.78, 〈 i 〉 p 〈 /i 〉 = 0.0001), and MS patients (7.38 ± 2.35, 〈 i 〉 p 〈 /i 〉 = 0.0033) and other controls (7.50 ± 0.37, 〈 i 〉 p 〈 /i 〉 = 0.0043). CSF CCL19 levels were also significantly higher in NMOSD patients in the relapsing phase (35.87 ± 27.07) than in those in the remitting phase (10.71 ± 3.62, 〈 i 〉 p 〈 /i 〉 = 0.0215). Serum IL-19 levels were lower in NMOSD patients in the relapsing phase (6.23 ± 1.95) than in those in the remitting phase (10.72 ± 4.46, 〈 i 〉 p 〈 /i 〉 = 0.0092). Further, there was a positive, significant correlation between serum IL-9 concentration and the Expanded Disability Status Scale score in the NMOSD patients in the relapsing phase ( 〈 i 〉 p 〈 /i 〉 = 0.04). 〈 b 〉 〈 i 〉 Conclusion: 〈 /i 〉 〈 /b 〉 In addition to IL-6 and IL-17A, IL-16 and CCL19 act as proinflammatory cytokines/chemokines, while IL-19 plays a protective role in NMOSD pathogenesis.
Type of Medium:
Online Resource
ISSN:
1021-7401
,
1423-0216
Language:
English
Publisher:
S. Karger AG
Publication Date:
2016
detail.hit.zdb_id:
1483035-8
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