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  • Hindawi Limited  (6)
  • Sun, Wei  (6)
Materialart
Verlag/Herausgeber
  • Hindawi Limited  (6)
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Sprache
Erscheinungszeitraum
  • 1
    Online-Ressource
    Online-Ressource
    Influences of Anlotinib on Cytochrome P450 Enzymes in Rats Using a Cocktail Method
    Hindawi Limited ; 2017
    In:  BioMed Research International Vol. 2017 ( 2017), p. 1-7
    Details
    In: BioMed Research International, Hindawi Limited, Vol. 2017 ( 2017), p. 1-7
    Kurzfassung: The present study aimed to investigate the effect of anlotinib (AL3818) on pharmacokinetics of cytochrome P450 (CYP) enzymes (CYP1A2, CYP2C6, CYP2D1, CYP2D2, and CYP3A1/2) by using five cocktail probe drugs in vivo. After pretreatment for 7 days with anlotinib (treatment group) or saline (control group) by oral administration, probe drugs phenacetin, tolbutamide, omeprazole, metoprolol, and midazolam were administered to rats by oral administration. Blood samples were obtained at a series of time-points and the concentrations of five probe drugs in plasma were determined by a UHPLC-MS/MS method. The results showed that treatment with anlotinib had no significant effect on rat CYP1A2, CYP2D2, and CYP2C6. However, anlotinib had a significant inductive effect on CYP2D1 and CYP3A1/2. Therefore, caution is needed during the concomitant use of anlotinib with other drugs metabolized by CYP2D1 and CYP3A1/2 because of potential drug-anlotinib interactions.
    Materialart: Online-Ressource
    ISSN: 2314-6133 , 2314-6141
    URL: Article
    DOI: 10.1155/2017/3619723
    Sprache: Englisch
    Verlag: Hindawi Limited
    Publikationsdatum: 2017
    ZDB Id: 2698540-8
    Standort Signatur Einschränkungen Verfügbarkeit
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    Online-Ressource
  • 2
    Online-Ressource
    Online-Ressource
    Compression Performance of Newly Designed Replaceable Tubular Steel Piers
    Hindawi Limited ; 2020
    In:  Advances in Materials Science and Engineering Vol. 2020 ( 2020-06-22), p. 1-19
    Details
    In: Advances in Materials Science and Engineering, Hindawi Limited, Vol. 2020 ( 2020-06-22), p. 1-19
    Kurzfassung: To rapidly restore the seismic behaviour of a portal steel bridge column after an earthquake, the installation of replaceable tubular steel piers at the root of a portal steel bridge column is proposed herein. In this study, various tubular steel piers with different structural measures were designed; an axial compression test and a numerical simulation of the newly designed tubular steel piers were performed. The effects of parameters such as the structure of stiffening rib, the strength of LYP steel plate, the size of low-yield-point (LYP) steel plate, and the size of outer constrained steel plate were discussed. The results indicate that local buckling of steel tubular plates is likely to occur at the upper or lower end of those specimens, which belong to type II-A specimens with stiffened LYP steel tubular plates or type III-A specimens with T-shaped LYP steel plates, respectively. This led to the LYP steel plate cannot fully display its function. For type III-B and III-C specimens with embedded LYP steel plates and constrained steel plates on both sides, when the outer steel tubular plates buckle, the internally constrained LYP steel plates provide support for the outer steel tubular plates. The plastic deformation of the specimens is sufficient, and the deformation performance is good. For type IV-A specimens with LYP steel tubular plates and constrained steel plates on both sides, the mechanical behaviour of the new tubular steel piers is significantly improved, and increasing the height of the constrained LYP steel tubular plate can improve the compressive behaviour of the new tubular steel pier. Considering the effect of the steel plate thickness on bearing capacity and deformation performance, the thickness t w of the outer constrained steel plate should be equal to the thickness t of the common steel tubular plate, and the thickness t f of the LYP steel tubular plate should satisfy t  ≤  t f  ≤ 2 t . Finally, a design formula is proposed to calculate the axial bearing capacity of newly designed tubular steel piers with constrained LYP steel plates.
    Materialart: Online-Ressource
    ISSN: 1687-8434 , 1687-8442
    URL: Article
    DOI: 10.1155/2020/7476293
    Sprache: Englisch
    Verlag: Hindawi Limited
    Publikationsdatum: 2020
    ZDB Id: 2501025-6
    Standort Signatur Einschränkungen Verfügbarkeit
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    Online-Ressource
  • 3
    Online-Ressource
    Online-Ressource
    Influences of Corydalis decumbens on the Activities of CYP450 Enzymes in Rats with a Cocktail Approach
    Hindawi Limited ; 2019
    In:  BioMed Research International Vol. 2019 ( 2019-01-21), p. 1-9
    Details
    In: BioMed Research International, Hindawi Limited, Vol. 2019 ( 2019-01-21), p. 1-9
    Kurzfassung: Corydalis decumbens , a Traditional Chinese Medicine, has been widely used for the alternative and/or complementary therapy of hypertension, arrhythmias rheumatoid arthritis, sciatica, stroke, hemiplegia, paraplegia, and vascular embolism. The aim of this study was to determinate the potential effects of Corydalis decumbens on the five cytochrome P450 (CYP) enzyme activities (CYP1A2, CYP3A4, CYP2C9, CYP2C19, and CYP2D6) by cocktail approach. To evaluate whether concurrent use of Corydalis decumbens interferes with the effect of several prescription drugs, saline (control group) or Corydalis decumbens (XTW group) were administrated via gavage for 7 successive days. A probe cocktail solution (phenacetin, omeprazole, metoprolol, tolbutamide, and midazolam) was given 24 h after the last dose of saline or Corydalis decumbens . A specific and sensitive UHPLC–MS/MS method was validated for the determination of five substrates and their metabolites in control group and XTW group. Our results indicated that Corydalis decumbens could have inductive effects of CYP2C19 and inhibit the activities of CYP1A2 and CYP3A4. However, Corydalis decumbens had no significant influence on CYP2C9 and CYP2D6. The herb-drug interaction should require more attention by careful monitoring and appropriate drug dosing adjustments to the concurrent use of western medications which were metabolized by CYP1A2, CYP2C19, and CYP3A4 in human— Corydalis decumbens , Cytochrome P450, Cocktail, Pharmacokinetics, herb–drug interactions.
    Materialart: Online-Ressource
    ISSN: 2314-6133 , 2314-6141
    URL: Article
    DOI: 10.1155/2019/9614781
    Sprache: Englisch
    Verlag: Hindawi Limited
    Publikationsdatum: 2019
    ZDB Id: 2698540-8
    Standort Signatur Einschränkungen Verfügbarkeit
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    Online-Ressource
  • 4
    Online-Ressource
    Online-Ressource
    Pharmacokinetics Interaction between Imatinib and Genistein in Rats
    Hindawi Limited ; 2015
    In:  BioMed Research International Vol. 2015 ( 2015), p. 1-7
    Details
    In: BioMed Research International, Hindawi Limited, Vol. 2015 ( 2015), p. 1-7
    Kurzfassung: The objective of this work was to investigate the effect of orally administered genistein on the pharmacokinetics of imatinib and N-desmethyl imatinib in rats. Twenty-five healthy male SD (Sprague-Dawley) rats were randomly divided into five groups: A group (control group), B group (multiple dose of 100 mg/kg genistein for consecutive 15 days), C group (multiple dose of 50 mg/kg genistein for consecutive 15 days), D group (a single dose of 100 mg/kg genistein), and E group (a single dose of 50 mg/kg genistein). A single dose of imatinib is administered orally 30 min after administration of genistein (100 mg/kg or 50 mg/kg). The pharmacokinetic parameters of imatinib and N-desmethyl imatinib were calculated by DAS 3.0 software. The multiple dose of 100 mg/kg or 50 mg/kg genistein significantly ( P 〈 0.05 ) decreased the AUC 0 - t and C max of imatinib. AUC 0 - t and the C max of N-desmethyl imatinib were also increased, but without any significant difference. However, the single dose of 100 mg/kg or 50 mg/kg genistein has no effect on the pharmacokinetics of imatinib and N-desmethyl imatinib. Those results indicated that multiple dose of genistein (100 mg/kg or 50 mg/kg) induces the metabolism of imatinib, while single dose of genistein has no effect.
    Materialart: Online-Ressource
    ISSN: 2314-6133 , 2314-6141
    URL: Article
    DOI: 10.1155/2015/368976
    Sprache: Englisch
    Verlag: Hindawi Limited
    Publikationsdatum: 2015
    ZDB Id: 2698540-8
    Standort Signatur Einschränkungen Verfügbarkeit
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    Online-Ressource
  • 5
    Online-Ressource
    Online-Ressource
    Determination of Anlotinib, a Tyrosine Kinase Inhibitor, in Rat Plasma by UHPLC-MS/MS and Its Application to a Pharmacokinetic Study
    Hindawi Limited ; 2019
    In:  Journal of Analytical Methods in Chemistry Vol. 2019 ( 2019-12-10), p. 1-7
    Details
    In: Journal of Analytical Methods in Chemistry, Hindawi Limited, Vol. 2019 ( 2019-12-10), p. 1-7
    Kurzfassung: Anlotinib is a novel inhibitor of receptor kinase tyrosine with multitargets and has a broad spectrum of inhibitory action on tumor angiogenesis and growth. A simple and rapid UHPLC-MS/MS bioanalytical method was validated for the determination of anlotinib in rat plasma, using imatinib as an internal standard. An Acquity BEH C18 column was used to separate analytes. The eluents consisted of formic acid/water (0.1 : 100, v/v) and acetonitrile with a mobile phase. A triple quadrupole mass spectrometer was operated for the quantification with multiple reaction monitoring (MRM) to determine transitions: 408.2 ⟶ 339.1 for anlotinib, and 494.3 ⟶ 394.1 for imatinib. The validated range was 0.1–50 ng/mL for anlotinib. Mean recovery rate of anlotinib in plasma was ≥99.32% and reproducible. Also, the intra- and interday precisions were both below 15%. This robust method was successfully applied to support the pharmacokinetic study of anlotinib in rats.
    Materialart: Online-Ressource
    ISSN: 2090-8865 , 2090-8873
    URL: Article
    DOI: 10.1155/2019/5016757
    Sprache: Englisch
    Verlag: Hindawi Limited
    Publikationsdatum: 2019
    ZDB Id: 2654178-6
    Standort Signatur Einschränkungen Verfügbarkeit
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    Online-Ressource
  • 6
    Online-Ressource
    Online-Ressource
    The Effect of Glycyrrhetinic Acid on Pharmacokinetics of Cortisone and Its Metabolite Cortisol in Rats
    Hindawi Limited ; 2012
    In:  Journal of Biomedicine and Biotechnology Vol. 2012 ( 2012), p. 1-5
    Details
    In: Journal of Biomedicine and Biotechnology, Hindawi Limited, Vol. 2012 ( 2012), p. 1-5
    Kurzfassung: The purpose of this paper is to study pharmacokinetics of cortisone (E) and its metabolite cortisol (F) in rats after administration of glycyrrhetinic acid (GA) and cortisone. Healthy male SD rats were randomized to be given 20 mg/kg E or E combined with 10 mg/kg GA. Blood samples were collected at 5, 10, 20, 40, 60, 90, 120, 150, 180, and 240 min after administration. The serum concentrations of E and F were determined by HLPC and pharmacokinetic parameters were calculated using DASver2.0 software. The parameters of AUC ( 0 − t ) , AUC ( 0 − ∞ ) , and C max for E in the group of E + GA were significantly higher than those in the group of E ( P 〈 0.01 ); the half-time ( t 1 / 2 β ) was extended compared to E ( P 〈 0.05 ) and CL/F was dropped obviously ( P 〈 0.01 ). The rise in AUC ( 0 − t ) , AUC ( 0 − ∞ ) , and C max for cortisol in the group of E + GA was significantly compared to the group of E ( P 〈 0.01 ). CL/F was lower than E ( P 〈 0.01 ) and the half-time ( t 1 / 2 β ) was slightly extended. In this study, we find that GA restrains the metabolism of E and F and thus increases AUC, t 1 / 2 β , and C max of E and F, which may be related to its inhibition effect on 11 β -hydroxysteroid dehydrogenase (11 β -HSD).
    Materialart: Online-Ressource
    ISSN: 1110-7243 , 1110-7251
    URL: Article
    DOI: 10.1155/2012/856324
    Sprache: Englisch
    Verlag: Hindawi Limited
    Publikationsdatum: 2012
    ZDB Id: 2698540-8
    ZDB Id: 2512507-2
    SSG: 12
    Standort Signatur Einschränkungen Verfügbarkeit
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