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  • Su, Yu  (4)
  • 1
    Online Resource
    Online Resource
    Aptamer-functionalized AuNCs nanogel for targeted delivery of docosahexaenoic acid to induce browning of white adipocytes
    Royal Society of Chemistry (RSC) ; 2023
    In:  Journal of Materials Chemistry B Vol. 11, No. 22 ( 2023), p. 4972-4979
    Details
    In: Journal of Materials Chemistry B, Royal Society of Chemistry (RSC), Vol. 11, No. 22 ( 2023), p. 4972-4979
    Abstract: Obesity, as a global public health concern, causes a series of metabolic disorders and other diseases. Browning of white fat (white adipocytes transforming to beige adipocytes) offers an attractive approach for obesity treatment. In the present study, aptamer-functionalized nanogel of gold nanoclusters (AuNCs), termed Apt-NG, was developed as the targeted delivery vehicle of browning agent docosahexaenoic acid (DHA). Apt-NG has multiple advantages, including nanoscale size, strong autofluorescence, low toxicity, and excellent targeting capability to white adipocytes. After treatment with DHA@Apt-NG, the morphology of lipid droplets changed evidently; meanwhile the triglyceride level decreased while the mitochondrial activity increased. The DHA@Apt-NG treatment effectively up-regulated the mRNA expression levels of Ucp1 , Pgc-1α , Pparg , and Prdm16 , which play important roles in browning of white adipocytes. This study provides a feasible strategy to achieve efficient browning of white adipocytes based on targeted delivery nanosystems, inspiring a new idea for obesity treatment.
    Type of Medium: Online Resource
    ISSN: 2050-750X , 2050-7518
    URL: Article
    DOI: 10.1039/D2TB02709G
    Language: English
    Publisher: Royal Society of Chemistry (RSC)
    Publication Date: 2023
    detail.hit.zdb_id: 2702241-9
    detail.hit.zdb_id: 2705149-3
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  • 2
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    Online Resource
    Browning of white adipocytes by gold nanocluster mediated electromagnetic induction heating hyperthermia
    Royal Society of Chemistry (RSC) ; 2022
    In:  Nanoscale Vol. 14, No. 4 ( 2022), p. 1187-1194
    Details
    In: Nanoscale, Royal Society of Chemistry (RSC), Vol. 14, No. 4 ( 2022), p. 1187-1194
    Abstract: Browning of white adipose tissue (WAT) is becoming an attractive therapeutic target for obesity. Great efforts have been made to develop effective approaches to induce browning. Unfortunately, the current methods suffer from a series of disadvantages, such as low efficiency, unsatisfactory stability, and side effects. Herein, we report a new approach to induce browning of 3T3-L1 white adipocytes based on electromagnetic induction heating (EIH) hyperthermia. In particular, adipocyte-targeting aptamer modified gold nanoclusters (Apt-AuNCs) were employed as the mediators of EIH. Apt-AuNCs had good biocompatibility and excellent targeting performance with white adipocytes. After Apt-AuNCs/EIH treatment, adipocytes with characteristic multilocular and small lipid droplets increased, and the content of triglycerides reduced effectively. Apt-AuNCs/EIH treatment also significantly increased the mitochondrial activity in adipocytes. Meanwhile, the mRNA levels of key genes that are involved in browning, for example UCP1, PRDM16, PPARγ, and PGC-1α, were upregulated. Finally, the induction mechanism of Apt-AuNCs/EIH on browning of white adipocytes was explained by the synergistic effects of EIH hyperthermia and pharmacological action of AuNCs. To the best of our knowledge, this is the first attempt on induction of browning by metal nanocluster-mediated EIH hyperthermia, thus providing an interesting and efficient channel for obesity treatment.
    Type of Medium: Online Resource
    ISSN: 2040-3364 , 2040-3372
    URL: Article
    DOI: 10.1039/D1NR07263C
    Language: English
    Publisher: Royal Society of Chemistry (RSC)
    Publication Date: 2022
    detail.hit.zdb_id: 2515664-0
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  • 3
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    Online Resource
    Anti-cancer effect of melittin-Au25(MHA)18 complexes on human cervical cancer HeLa cells
    Elsevier BV ; 2022
    In:  Journal of Drug Delivery Science and Technology Vol. 68 ( 2022-02), p. 103078-
    Details
    In: Journal of Drug Delivery Science and Technology, Elsevier BV, Vol. 68 ( 2022-02), p. 103078-
    Type of Medium: Online Resource
    ISSN: 1773-2247
    URL: Article
    DOI: 10.1016/j.jddst.2021.103078
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2022
    detail.hit.zdb_id: 2542935-8
    SSG: 15,3
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  • 4
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    Online Resource
    Engineering Metal Nanoclusters for Targeted Therapeutics: From Targeting Strategies to Therapeutic Applications
    Wiley ; 2021
    In:  Advanced Functional Materials Vol. 31, No. 51 ( 2021-12)
    Details
    In: Advanced Functional Materials, Wiley, Vol. 31, No. 51 ( 2021-12)
    Abstract: Metal nanoclusters (NCs) have recently attracted great interest in biomedical applications due to their ultrasmall size, good biocompatibility, and unique molecule‐like physical and chemical properties. Metal NCs can be rationally designed and integrated with various targeting moieties to achieve unique physicochemical properties and functions. For therapeutic applications, these multifunctional surface‐modified NCs can provide distinctive advantages over native metal NCs, such as improved therapeutic effects and reduced side effects. In this review, the design principles of targeting strategies for metal NCs and their composites, including passive and active targeting, and physical and chemical targeting are first discussed. The authors then focus on the recent achievements in the application of metal NCs in targeted therapeutics, including chemotherapy, phototherapy, and radiotherapy. Finally, the authors’ perspectives on the challenges and opportunities of developing metal NCs in targeted therapeutics, further paving their way for potential clinical applications are provided.
    Type of Medium: Online Resource
    ISSN: 1616-301X , 1616-3028
    URL: Issue
    URL: Article
    DOI: 10.1002/adfm.v31.51
    DOI: 10.1002/adfm.202105662
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 2029061-5
    detail.hit.zdb_id: 2039420-2
    SSG: 11
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