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  • 1
    Online Resource
    Online Resource
    Ultra-Early Intravenous Stroke Thrombolysis : Do All Patients Benefit Similarly?
    Ovid Technologies (Wolters Kluwer Health) ; 2013
    In:  Stroke Vol. 44, No. 10 ( 2013-10), p. 2913-2916
    Details
    In: Stroke, Ovid Technologies (Wolters Kluwer Health), Vol. 44, No. 10 ( 2013-10), p. 2913-2916
    Abstract: We previously reported increased benefit and reduced mortality after ultra-early stroke thrombolysis in a single center. We now explored in a large multicenter cohort whether extra benefit of treatment within 90 minutes from symptom onset is uniform across predefined stroke severity subgroups, as compared with later thrombolysis. Methods— Prospectively collected data of consecutive ischemic stroke patients who received IV thrombolysis in 10 European stroke centers were merged. Logistic regression tested association between treatment delays, as well as excellent 3-month outcome (modified Rankin scale, 0–1), and mortality. The association was tested separately in tertiles of baseline National Institutes of Health Stroke Scale. Results— In the whole cohort (n=6856), shorter onset-to-treatment time as a continuous variable was significantly associated with excellent outcome ( P 〈 0.001). Every fifth patient had onset-to-treatment time≤90 minutes, and these patients had lower frequency of intracranial hemorrhage. After adjusting for age, sex, admission glucose level, and year of treatment, onset-to-treatment time≤90 minutes was associated with excellent outcome in patients with National Institutes of Health Stroke Scale 7 to 12 (odds ratio, 1.37; 95% confidence interval, 1.11–1.70; P =0.004), but not in patients with baseline National Institutes of Health Stroke Scale 〉 12 (odds ratio, 1.00; 95% confidence interval, 0.76–1.32; P =0.99) and baseline National Institutes of Health Stroke Scale 0 to 6 (odds ratio, 1.04; 95% confidence interval, 0.78–1.39; P =0.80). In the latter, however, an independent association (odds ratio, 1.51; 95% confidence interval, 1.14–2.01; P 〈 0.01) was found when considering modified Rankin scale 0 as outcome (to overcome the possible ceiling effect from spontaneous better prognosis of patients with mild symptoms). Ultra-early treatment was not associated with mortality. Conclusions— IV thrombolysis within 90 minutes is, compared with later thrombolysis, strongly and independently associated with excellent outcome in patients with moderate and mild stroke severity.
    Type of Medium: Online Resource
    ISSN: 0039-2499 , 1524-4628
    URL: Article
    DOI: 10.1161/STROKEAHA.111.000819
    RVK:
    XA 10000
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2013
    detail.hit.zdb_id: 1467823-8
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  • 2
    Online Resource
    Online Resource
    Symptomatic Intracranial Hemorrhage After Stroke Thrombolysis : Comparison of Prediction Scores
    Ovid Technologies (Wolters Kluwer Health) ; 2014
    In:  Stroke Vol. 45, No. 3 ( 2014-03), p. 752-758
    Details
    In: Stroke, Ovid Technologies (Wolters Kluwer Health), Vol. 45, No. 3 ( 2014-03), p. 752-758
    Abstract: Several prognostic scores have been developed to predict the risk of symptomatic intracranial hemorrhage (sICH) after ischemic stroke thrombolysis. We compared the performance of these scores in a multicenter cohort. Methods— We merged prospectively collected data of patients with consecutive ischemic stroke who received intravenous thrombolysis in 7 stroke centers. We identified and evaluated 6 scores that can provide an estimate of the risk of sICH in hyperacute settings: MSS (Multicenter Stroke Survey); HAT (Hemorrhage After Thrombolysis); SEDAN (blood sugar, early infarct signs, [hyper]dense cerebral artery sign, age, NIH Stroke Scale); GRASPS (glucose at presentation, race [Asian] , age, sex [male], systolic blood pressure at presentation, and severity of stroke at presentation [NIH Stroke Scale] ); SITS (Safe Implementation of Thrombolysis in Stroke); and SPAN (stroke prognostication using age and NIH Stroke Scale)-100 positive index. We included only patients with available variables for all scores. We calculated the area under the receiver operating characteristic curve (AUC-ROC) and also performed logistic regression and the Hosmer–Lemeshow test. Results— The final cohort comprised 3012 eligible patients, of whom 221 (7.3%) had sICH per National Institute of Neurological Disorders and Stroke, 141 (4.7%) per European Cooperative Acute Stroke Study II, and 86 (2.9%) per Safe Implementation of Thrombolysis in Stroke criteria. The performance of the scores assessed with AUC-ROC for predicting European Cooperative Acute Stroke Study II sICH was: MSS, 0.63 (95% confidence interval, 0.58–0.68); HAT, 0.65 (0.60–0.70); SEDAN, 0.70 (0.66–0.73); GRASPS, 0.67 (0.62–0.72); SITS, 0.64 (0.59–0.69); and SPAN-100 positive index, 0.56 (0.50–0.61). SEDAN had significantly higher AUC-ROC values compared with all other scores, except for GRASPS where the difference was nonsignificant. SPAN-100 performed significantly worse compared with other scores. The discriminative ranking of the scores was the same for the National Institute of Neurological Disorders and Stroke, and Safe Implementation of Thrombolysis in Stroke definitions, with SEDAN performing best, GRASPS second, and SPAN-100 worst. Conclusions— SPAN-100 had the worst predictive power, and SEDAN constantly the highest predictive power. However, none of the scores had better than moderate performance.
    Type of Medium: Online Resource
    ISSN: 0039-2499 , 1524-4628
    URL: Article
    DOI: 10.1161/STROKEAHA.113.003806
    RVK:
    XA 10000
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2014
    detail.hit.zdb_id: 1467823-8
    Location Call Number Limitation Availability
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  • 3
    Online Resource
    Online Resource
    Abstract 62: GRASPS Score to Predict Risk of Clinically Relevant Symptomatic Intracranial Hemorrhage after Intravenous Tissue Plasminogen Activator
    Ovid Technologies (Wolters Kluwer Health) ; 2015
    In:  Stroke Vol. 46, No. suppl_1 ( 2015-02)
    Details
    In: Stroke, Ovid Technologies (Wolters Kluwer Health), Vol. 46, No. suppl_1 ( 2015-02)
    Abstract: Background: The NINDS Study definition of symptomatic hemorrhage (sICH) after intravenous tissue plasminogen activator (tPA), requiring only minimal early worsening and minimal petechial hemorrhage, is now widely recognized as overly inclusive. Clinically relevant sICH is better defined by at least moderate worsening and parenchymal hematoma. The 6-item GRASPS scale for predicting sICH was derived from the national US Get with the Guidelines - Stroke registry based on the NINDS Study definition. For use in clinical practice, it is desirable to recalibrate the GRASPS scale to predict more stringently defined symptomatic hemorrhage. Methods: We merged prospectively collected data of patients with consecutive ischemic stroke who received tPA in 7 stroke centers. We applied the GRASPS (glucose at presentation, race [Asian], age, sex [male] , systolic blood pressure at presentation, and severity of stroke at presentation [NIH Stroke Scale]) to predict Safe Implementation of Thrombolysis in Stroke (SITS)-defined sICH. To derive a monotonic predictive model, we used a generalized additive model framework and fit 6 different transformations of the GRASPS score: linear scale, log scale, without and with splines, and without and with local smoothing (“loess”) to identify any non-parametric patterns. Results: The final cohort comprised 5274 eligible patients, of whom 143 (2.7%) had symptomatic ICH per SITS criteria. Based on favorable residual deviance scores and Akaike's information criterion scores, the linear transformation of raw GRASPS scores provided the best fit. With this model, the area under the curve for predicting SITS sICH was 0.68 (95% CI 0.63-0.72). Risk score values for cardinal GRASPS scale points included 0.6% for GRASPS 50, 2.4% for GRASPS 70, and 9.5% for GRASPS 90. Conclusions: The GRASPS scale showed moderate performance in predicting SITS-defined symptomatic intracerebral hemorrhage after IV tPA. With the predictive values available from this study, the GRASPS score can be used to assess risk of clinically relevant symptomatic hemorrhage following thrombolytic therapy.
    Type of Medium: Online Resource
    ISSN: 0039-2499 , 1524-4628
    URL: Article
    DOI: 10.1161/str.46.suppl_1.62
    RVK:
    XA 10000
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2015
    detail.hit.zdb_id: 1467823-8
    Location Call Number Limitation Availability
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    Online Resource
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