In:
Genes & Development, Cold Spring Harbor Laboratory, Vol. 18, No. 20 ( 2004-10-15), p. 2485-2490
Abstract:
Three-dimensional organization of a gene locus is important for its regulation, as recently demonstrated for the β- globin locus. When actively expressed, the cis -regulatory elements of the β- globin locus are in proximity in the nuclear space, forming a compartment termed the Active Chromatin Hub (ACH). However, it is unknown which proteins are involved in ACH formation. Here, we show that EKLF, an erythroid transcription factor required for adult β- globin gene transcription, is also required for ACH formation. We conclude that transcription factors can play an essential role in the three-dimensional organization of gene loci.
Type of Medium:
Online Resource
ISSN:
0890-9369
,
1549-5477
Language:
English
Publisher:
Cold Spring Harbor Laboratory
Publication Date:
2004
detail.hit.zdb_id:
806684-X
detail.hit.zdb_id:
1467414-2
SSG:
12
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