In:
Acta Endocrinologica, Oxford University Press (OUP), Vol. 113, No. 2 ( 1986-10), p. 298-304
Abstract:
Abstract. Glucocorticoid induced hypertension has been regarded as independent of sodium (Na), in contrast to mineralocorticoid induced hypertension, which is Na + -dependent. These studies compare the effect of Na + depletion and potassium (K + ) loading on glucocorticoid hypertension induced by cortisol in conscious sheep. Cortisol (480 mg/d) for 5 days, in sheep on a normal chaff diet (90–140 mmol/d Na + , 200–250 mmol/d K + ) increased mean arterial pressure by 18 mmHg on day 5, increased plasma Na + concentration, reduced plasma K + concentration, and did not change urinary Na + excretion. Following Na + depletion (Na + loss 603 ± 49 mmol), cortisol increased mean arterial pressure from 70 ± 1 mmHg to 76 ± 3 mmHg on day 5 ( P 〈 0.001) and the increase in pressure was significantly less than the increase seen on the normal diet ( P 〈 0.05). Plasma Na + increased and plasma K + decreased. Urinary Na + and K + excretion was unchanged. KCl loading (700–900 mmol/day) for 10 days had no effect on the maximum rise in mean arterial pressure (+18 mmHg with cortisol in K + loaded sheep). Plasma Na + and K + fell, and urinary Na + excretion increased during the infusion. These studies show that Na + depletion, but not KCl loading, reduced cortisol induced hypertension in sheep. These data show that glucocorticoid hypertension is not independent of Na + status.
Type of Medium:
Online Resource
ISSN:
0804-4643
,
1479-683X
DOI:
10.1530/acta.0.1130298
Language:
Unknown
Publisher:
Oxford University Press (OUP)
Publication Date:
1986
detail.hit.zdb_id:
1485160-X
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