In:
PLOS Neglected Tropical Diseases, Public Library of Science (PLoS), Vol. 15, No. 4 ( 2021-4-15), p. e0009327-
Abstract:
The SARS-CoV-2 pandemic has forced health authorities across the world to take important decisions to curtail its spread. Genomic epidemiology has emerged as a valuable tool to understand introductions and spread of the virus in a specific geographic location. Methodology/Principal findings Here, we report the sequences of 59 SARS-CoV-2 samples from inhabitants of the Colombian Amazonas department. The viral genomes were distributed in two robust clusters within the distinct GISAID clades GH and G. Spatial-temporal analyses revealed two independent introductions of SARS-CoV-2 in the region, one around April 1, 2020 associated with a local transmission, and one around April 2, 2020 associated with other South American genomes (Uruguay and Brazil). We also identified ten lineages circulating in the Amazonas department including the P.1 variant of concern (VOC). Conclusions/Significance This study represents the first genomic epidemiology investigation of SARS-CoV-2 in one of the territories with the highest report of indigenous communities of the country. Such findings are essential to decipher viral transmission, inform on global spread and to direct implementation of infection prevention and control measures for these vulnerable populations, especially, due to the recent circulation of one of the variants of concern (P.1) associated with major transmissibility and possible reinfections.
Type of Medium:
Online Resource
ISSN:
1935-2735
DOI:
10.1371/journal.pntd.0009327
DOI:
10.1371/journal.pntd.0009327.g001
DOI:
10.1371/journal.pntd.0009327.g002
DOI:
10.1371/journal.pntd.0009327.g003
DOI:
10.1371/journal.pntd.0009327.g004
DOI:
10.1371/journal.pntd.0009327.t001
DOI:
10.1371/journal.pntd.0009327.t002
DOI:
10.1371/journal.pntd.0009327.t003
DOI:
10.1371/journal.pntd.0009327.s001
DOI:
10.1371/journal.pntd.0009327.s002
DOI:
10.1371/journal.pntd.0009327.s003
DOI:
10.1371/journal.pntd.0009327.s004
DOI:
10.1371/journal.pntd.0009327.s005
DOI:
10.1371/journal.pntd.0009327.s006
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2021
detail.hit.zdb_id:
2429704-5
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