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  • 1
    In: Journal of the American Heart Association, Ovid Technologies (Wolters Kluwer Health), Vol. 8, No. 17 ( 2019-09-03)
    Abstract: Left ventricular ( LV ) involvement is common in arrhythmogenic right ventricular cardiomyopathy ( ARVC ). We aim to evaluate LV involvement in ARVC patients by cardiovascular magnetic resonance feature tracking. Methods and Results Sixty‐eight patients with ARVC and 30 controls were prospectively enrolled. ARVC patients were divided into 2 subgroups: the preserved LV ejection fraction (LVEF) group ( LVEF ≥55%, n=27) and the reduced LVEF group ( LVEF 〈 55%, n=41). Cardiovascular magnetic resonance with late gadolinium enhancement ( LGE ) and cardiovascular magnetic resonance feature tracking were performed in all subjects. LV global and regional (basal, mid, apical) peak strain ( PS ) in radial, circumferential and longitudinal directions were assessed, respectively. Right ventricular global PS in three directions were also analyzed. Compared with the controls, LV global and regional PS were all significantly impaired in the reduced LVEF group (all P 〈 0.05). However, only LV global longitudinal PS as well as mid and apical longitudinal PS were impaired in the preserved LVEF group (all P 〈 0.05), and all these parameters were significantly associated with right ventricular global radial PS ( r =−0.47, −0.47, and −0.49, respectively, all P 〈 0.001). The reduced LVEF group showed significantly higher prevalence of LGE (95.10% versus 63.00%, P =0.002) than the preserved LVEF group. Moreover, LV radial PS was significantly reduced in LV segments with LGE (33.15±20.42%, n=46) than those without LGE (41.25±15.98%, n=386) in the preserved LVEF group ( P =0.016). Conclusions In patients with ARVC , cardiovascular magnetic resonance feature tracking could detect early LV dysfunction, which was associated with LV myocardial LGE and right ventricular dysfunction.
    Type of Medium: Online Resource
    ISSN: 2047-9980
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2019
    detail.hit.zdb_id: 2653953-6
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  • 2
    In: Frontiers in Cardiovascular Medicine, Frontiers Media SA, Vol. 9 ( 2022-5-4)
    Type of Medium: Online Resource
    ISSN: 2297-055X
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2022
    detail.hit.zdb_id: 2781496-8
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  • 3
    In: Korean Journal of Radiology, XMLink, Vol. 20, No. 1 ( 2019), p. 114-
    Type of Medium: Online Resource
    ISSN: 1229-6929 , 2005-8330
    Language: English
    Publisher: XMLink
    Publication Date: 2019
    detail.hit.zdb_id: 2085349-X
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  • 4
    In: Frontiers in Cardiovascular Medicine, Frontiers Media SA, Vol. 8 ( 2021-10-11)
    Abstract: Objectives: Left ventricular (LV) involvement has been associated with unfavorable prognosis in arrhythmogenic cardiomyopathy (ACM). We aim to evaluate LV mechanics by cardiovascular magnetic resonance-feature tracking (CMR-FT) in ACM patients with right ventricular (RV) dysfunction. Methods: We retrospectively recruited ACM patients diagnosed according to the revised Task Force Criteria (rTFC) from January 2015 to July 2017. All patients underwent CMR examinations and collections of clinical, electrocardiographic data. The strain and dyssynchrony parameters of LV and RV were analyzed. These patients were followed, and primary study outcome was defined as a composite of cardiovascular events (arrhythmic events and heart transplantation), secondary study outcome included arrhythmic events. Results: Eighty-nine ACM patients (40.40 ± 13.98 years, 67.42% male) were included. LV and RV ejection fractions were 49.12 ± 12.02% and 22.28 ± 10.11%, respectively. During a median (IQR) follow-up for 18.20 (11.60-30.04) months, 30 patients experienced cardiovascular events which included 22 patients who experienced arrhythmic events. Patients with cardiovascular events had impaired LV global longitudinal strain (−10.82 ± 2.77 vs. −12.61 ± 3.18%, p = 0.010), impaired LV global circumferential strain (−11.81 ± 2.40 vs. −13.04 ± 2.83%, p = 0.044), and greater LV longitudinal dyssynchrony (LVLD) (80.98 ± 30.98 vs. 64.23 ± 25.51 ms, p = 0.012) than those without. After adjusting for age, sex, and other confounding factors, LVLD ≥89.15 ms was an independent risk factor for cardiovascular events (HR: 4.50, 95% CI: 1.94 to 10.42; p = 0.001) and for arrhythmic events (HR: 4.79, 95% CI: 1.74 to 13.20; p = 0.003). Conclusions: LVLD by CMR-FT was an independent risk factor for cardiovascular and arrhythmic events in ACM patients in advanced stage, which could provide prognostic value for this subtype.
    Type of Medium: Online Resource
    ISSN: 2297-055X
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2021
    detail.hit.zdb_id: 2781496-8
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  • 5
    In: Journal of Thoracic Imaging, Ovid Technologies (Wolters Kluwer Health), Vol. 37, No. 1 ( 2022-01), p. 26-33
    Abstract: Hypertension (HTN) patients suffer from increased risk of left ventricular (LV) diastolic dysfunction and LV hypertrophy (LVH). Evaluation of early LV diastolic function requires accurate noninvasive diagnostic tools. The aim of this study was to evaluate whether cardiovascular magnetic resonance feature-tracking (CMR-FT) could detect early LV dysfunction and evaluate LV-left atrium (LA) correlation in HTN patients. Materials and Methods: In all, 89 HTN patients and 38 age-matched and sex-matched controls were retrospectively enrolled and underwent CMR examination. HTN patients were divided into LVH (n=38) and non-LVH (n=51) groups. All LV deformation parameters were analyzed in radial, circumferential, and longitudinal directions, including peak strain, peak systolic strain rate and peak diastolic strain rate (PDSR), LA strain and strain rate (SR), including LA reservoir function (εs, SRs), conduit function (εe, SRe), and booster pump function (εa, SRa). Results: Compared with controls, the LV PDSR in radial, circumferential, and longitudinal directions and the LA reservoir and conduit function were significantly impaired in HTN patients regardless of LVH (all P 〈 0.05). LV longitudinal and radial PDSR were correlated with LA reservoir and conduit function (all P 〈 0.01). Among all LV and LA impaired deformation parameters, the longitudinal PDSR (in LV) and εe (in LA) were the most sensitive parameter for the discrimination between non-LVH and healthy volunteers, with an area under the curve of 0.70 (specificity 79%, sensitivity 55%) and 0.76 (specificity 95%, sensitivity 49%), respectively. The area under the curve reached 0.81 (specificity 82%, sensitivity 75%) combined with the longitudinal PDSR and εe. Conclusion: CMR-FT could detect early LV diastolic dysfunction in HTN patients, which might be associated with LA reservoir and conduit dysfunction.
    Type of Medium: Online Resource
    ISSN: 0883-5993
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2022
    detail.hit.zdb_id: 2048799-X
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  • 6
    In: World Neurosurgery, Elsevier BV, Vol. 119 ( 2018-11), p. e94-e105
    Type of Medium: Online Resource
    ISSN: 1878-8750
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2018
    detail.hit.zdb_id: 2530041-6
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  • 7
    Online Resource
    Online Resource
    Scientific Research Publishing, Inc. ; 2015
    In:  Journal of Materials Science and Chemical Engineering Vol. 03, No. 07 ( 2015), p. 154-161
    In: Journal of Materials Science and Chemical Engineering, Scientific Research Publishing, Inc., Vol. 03, No. 07 ( 2015), p. 154-161
    Type of Medium: Online Resource
    ISSN: 2327-6045 , 2327-6053
    Language: Unknown
    Publisher: Scientific Research Publishing, Inc.
    Publication Date: 2015
    detail.hit.zdb_id: 2781644-8
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  • 8
    Online Resource
    Online Resource
    The Electrochemical Society ; 2019
    In:  ECS Meeting Abstracts Vol. MA2019-04, No. 5 ( 2019-06-30), p. 260-260
    In: ECS Meeting Abstracts, The Electrochemical Society, Vol. MA2019-04, No. 5 ( 2019-06-30), p. 260-260
    Abstract: Nowdays, a series of transition-metal oxides (TMOs) such as MnO 2 , MoO 3 , Co 3 O 4 , CoO, and NiO have been widely studied as supercapacitive materials because of their low cost and high theoretical specific capacitance. As a low-oxidized cobalt compound, to date, CoO has been successfully applied as Li-ion battery anodes and showed satisfactory Li-ion storage capacities. The theoretical specific capacitance of CoO reaches 4292 F g -1 . This value is higher than that of NiO (2573 F g -1 ), MnO 2 (1370 F g -1 ), and Co 3 O 4 (3560 F g -1 ). However, the practical application of CoO is severely hindered by its easily oxidized character (CoO is oxidized to Co 3 O 4 after exposure in air) and the poor electrical conductivity (intrinsic semiconducting or insulating property). The poor conductivity is also one of the main reasons that limit the application of other TMOs in constructing high performance supercapacitors. To overcome these challgenges, we report a metallic Co doped CoO-based energy storage material by elaborately tailoring both the electrical conductivity and material configuration. The cobalt-doped CoO (denoted as CoO/Co) heterostructure is designed to improve the electrical conductivity. The metallic Co, acting as a current “expressway,” effectively improves the electrical conductivity of the composite, thus accelerating the electron transport. Additonally, an ultrathin layer of amorphous carbon is generated on the surface of heterostructure to prevent further oxidation of CoO/Co. This amorphous carbon shell serves as a surface stabilizer to hinder further oxidation of Co/CoO, thus sustaining good stability of supercapacitor. As a result, the as-prepared composite exhibits an excellent supercapacitor performance of 2165.7 F g -1 at a scanning rate of 10 mV s -1 . An asymmetric supercapacitor cell fabricated using the c and active carbon achieves a maximum energy density of 146.3 Wh kg -1 at a power density of 1800 W kg -1 , and the maximum of 27000 W kg -1 can be obtained with a remaining energy density of 63.0 Wh kg −1 . Even more importantly, such a composite also showed a good cycling ability and improved long-term storage stability. As this supercapacitive material can be prepared with a high yield by a facial low-cost route, it is highly expected that it could be a promising material for electrochemical energy storage in practical applications.
    Type of Medium: Online Resource
    ISSN: 2151-2043
    Language: Unknown
    Publisher: The Electrochemical Society
    Publication Date: 2019
    detail.hit.zdb_id: 2438749-6
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  • 9
    In: European Heart Journal - Cardiovascular Imaging, Oxford University Press (OUP), Vol. 23, No. 8 ( 2022-07-21), p. 1006-1015
    Abstract: Echocardiographic studies suggest that strain is related to myocardial fibrosis (MF) and ventricular arrhythmias (VA) in hypertrophic cardiomyopathy (HCM) patients. Cardiac magnetic resonance feature tracking (CMR-FT) also allows strain analysis, but little is known whether it provides incremental value to late gadolinium enhancement imaging (LGE). This study aimed to explore the relationship between CMR-FT-derived strain parameters and histopathology MF and VA and its incremental value to LGE in obstructive HCM (HOCM) patients undergoing septal myectomy. Methods and results One hundred and twenty-three symptomatic HOCM patients underwent CMR examination, followed by septal myectomy. The abnormally increased histological MF was defined as higher than the mean + 2 standard deviation (SD) of nine control autopsy subjects who had no history of cardiovascular disease. Septal strain parameters and septal LGE were evaluated at the site of surgical myectomy. Among HOCM patients without LGE, septal circumferential (P = 0.003), longitudinal (P = 0.001), and radial (P = 0.02) strains were significantly impaired in patients with increased histological MF than those without. Histological MF was significantly associated with septal circumferential strain (r = 0.32, P & lt; 0.001), septal longitudinal strain (r = 0.42, P & lt; 0.001), and septal radial strain (r = −0.27, P = 0.003). On multivariate analysis, septal longitudinal strain was independently associated with histological MF [β, 0.19 (0.05–0.34); P = 0.01], and VA [odds ratio, 1.10 (1.01–1.19); P = 0.02] . Moreover, septal longitudinal strain was incremental to septal %LGE in detecting increased MF (P = 0.001) and VA (P = 0.048). Conclusions Septal longitudinal strain at CMR is independently related to histological MF and occurrence of VA in HOCM patients. Moreover, it provides incremental value over LGE in detecting increased MF and VA.
    Type of Medium: Online Resource
    ISSN: 2047-2404 , 2047-2412
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2022
    detail.hit.zdb_id: 2042482-6
    detail.hit.zdb_id: 2647943-6
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  • 10
    In: European Heart Journal - Cardiovascular Imaging, Oxford University Press (OUP), Vol. 24, No. 4 ( 2023-03-21), p. 492-502
    Abstract: This study aims to validate and compare the feasibility of T1ρ and native longitudinal relaxation time (T1) mapping in detection of myocardial fibrosis in patients with non-ischaemic cardiomyopathy, focusing on the performance of both methods in identifying late gadolinium enhancement (LGE) grey zone. Methods and results Twenty-seven hypertrophic cardiomyopathy (HCM) patients, 16 idiopathic dilated cardiomyopathy (DCM) patients, and 18 healthy controls were prospectively enrolled for native T1 and T1ρ mapping imaging and then all the patients underwent enhancement scan for LGE extent and extracellular volume (ECV) values. In LGE positive patients, the LGE areas were divided into LGE core (6 SDs above remote myocardium) and grey zone (2–6 SDs above remote myocardium) according to the signal intensity of LGE. Both HCM and DCM patients showed significantly higher native T1 values and T1ρ values than controls no matter the presence of LGE (all P & lt; 0.01). There were significant differences in native T1 and T1ρ values among four different types of myocardia (LGE core, grey zone, remote area and control, P & lt; 0.0001). However, the T1ρ values of grey zone were significantly higher than control (P & lt; 0.01), while the native T1 values were not (P = 0.089). T1ρ values were significantly associated with both native T1 values (r = 0.54, P & lt; 0.001) and ECV values (r = 0.54, P & lt; 0.001). Conclusion T1ρ mapping is a feasible method to detect myocardial fibrosis in patients with non-ischaemic cardiomyopathy no matter the presence of LGE. Compared with native T1, T1ρ may serve as a better discriminator in the identification of LGE grey zone.
    Type of Medium: Online Resource
    ISSN: 2047-2404 , 2047-2412
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2023
    detail.hit.zdb_id: 2042482-6
    detail.hit.zdb_id: 2647943-6
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