In:
Pediatric Allergy and Immunology, Wiley, Vol. 27, No. 6 ( 2016-09), p. 580-590
Abstract:
We aimed to systematically review observational studies investigating the relationship between vitamin D levels and allergic rhinitis ( AR ). Methods Studies were selected if they evaluated the relationship between vitamin D levels and AR , and included studies that evaluated other allergic conditions if those studies also contained data on AR . We assessed the incidence and prevalence of AR according to vitamin D levels and compared vitamin D levels in patients with AR to levels in controls. Results Nineteen studies were selected. Of these, only seven focused solely on AR ; 10 studies evaluated the other allergic diseases as well as AR ; and two studies evaluated asthma primarily, but also included data on patients with AR . The pooled odds ratios ( OR s) for the incidence of AR according to vitamin D levels were not statistically significant for either children or adults. Lower vitamin D levels were associated with a higher AR prevalence only in children (pooled OR [95% confidence interval ( CI )], 0.75 [0.58, 0.98] ). The pooled mean vitamin D level in patients with AR was lower than that of controls only in children (pooled means difference [95% CI ], −7.63 [−13.08, −2.18] ). Conclusions Prior vitamin D levels were not related to developing AR , but lower vitamin D levels were associated with a higher AR prevalence only in children. There is insufficient evidence to support vitamin D supplementation for AR prevention. However, physicians should consider evaluating patients for vitamin D deficiency during AR management, especially in children.
Type of Medium:
Online Resource
ISSN:
0905-6157
,
1399-3038
DOI:
10.1111/pai.2016.27.issue-6
Language:
English
Publisher:
Wiley
Publication Date:
2016
detail.hit.zdb_id:
2008584-9
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