In:
The EMBO Journal, Springer Science and Business Media LLC, Vol. 36, No. 3 ( 2017-02), p. 346-360
Abstract:
image miR‐34c‐5p is a novel player in TCR ‐stimulated human naive CD 4 T cells, emerging as a common link between cell activation and HIV replication. Its down‐regulation on HIV ‐1 or HIV ‐2 infection may be an anti‐viral cell response to limit HIV production. miR‐34c‐5p is a novel regulator of TCR ‐mediated naive CD 4 T‐cell activation. Small RNA ‐seq reveals stable miR levels in human naive CD 4 T cells exposed to HIV . HIV infection of TCR ‐activated naive CD 4 T cells results in miR‐34c‐5p down‐regulation. miR‐34c‐5p overexpression promotes HIV replication.
Type of Medium:
Online Resource
ISSN:
0261-4189
,
1460-2075
DOI:
10.15252/embj.201694335
Language:
English
Publisher:
Springer Science and Business Media LLC
Publication Date:
2017
detail.hit.zdb_id:
1467419-1
detail.hit.zdb_id:
586044-1
SSG:
12
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