In:
FEBS Letters, Wiley, Vol. 377, No. 2 ( 1995-12-18), p. 267-270
Kurzfassung:
The ability of the 72 kDa gelatinase A to cleave the amyloid protein precursor (APP) was investigated. HeLa cells were transfected with an APP 695 plasmid. The cells were incubated with gelatinase A, which cleaved the 110 kDa cell‐surface APP, releasing a 100 kDa form of the protein. A peptide homologous to the β‐secretase site was cleaved by gelatinase A adjacent to a glutamate residue at position −3 (βA4 numbering system). A peptide homologous to the α‐secretase site was not cleaved. The results demonstrate that 72 kDa gelatinase A is not an α‐secretase, but that it may have a β‐secretase activity.
Materialart:
Online-Ressource
ISSN:
0014-5793
,
1873-3468
DOI:
10.1016/0014-5793(95)01358-X
Sprache:
Englisch
Verlag:
Wiley
Publikationsdatum:
1995
ZDB Id:
1460391-3
SSG:
12
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