In:
RSC Advances, Royal Society of Chemistry (RSC), Vol. 12, No. 12 ( 2022), p. 7133-7148
Abstract:
A series of new organic ligands (5 Z ,5 Z ′)-2,2′-(alkane-α,ω-diyldiselenyl)-bis-5-(2-pyridylmethylene)-3,5-dihydro-4 H -imidazol-4-ones (L) consisting of two 5-(2-pyridylmethylene)-3,5-dihydro-4 H -imidazol-4-one units linked with polymethylene chains of various lengths ( n = 2–10, where n is the number of CH 2 units) have been synthesized. The reactions of these ligands with CuCl 2 ·2H 2 O and CuClO 4 ·6H 2 O gave Cu 2+ or Cu 1+ containing mono- and binuclear complexes with Cu 2 LCl x ( x = 2–4) or CuL(ClO 4 ) y ( y = 1, 2) composition. It was shown that the agents reducing Cu 2+ to Cu 1+ in the course of complex formation can be both a ligand and an organic solvent in which the reaction is carried out. This fundamentally distinguishes the selenium-containing ligands L from their previously described sulfur analogs, which by themselves are not capable of reducing Cu 2+ during complexation under the same conditions. A higher cytotoxicity and reasonable selectivity to cancer cell lines for synthesized complexes of selenium-containing ligands was shown; unlike sulfur analogs, ligands L themselves demonstrate a high cytotoxicity, comparable in some cases to the toxicity of copper-containing complexes.
Type of Medium:
Online Resource
ISSN:
2046-2069
Language:
English
Publisher:
Royal Society of Chemistry (RSC)
Publication Date:
2022
detail.hit.zdb_id:
2623224-8
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