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  • Sklorz, Martin  (2)
  • Biology  (2)
  • 1
    Online Resource
    Online Resource
    Atmosphärische Aerosole: Quellen, Vorkommen, Zusammensetzung
    Wiley ; 2007
    In:  Chemie in unserer Zeit Vol. 41, No. 3 ( 2007-06), p. 220-230
    Details
    In: Chemie in unserer Zeit, Wiley, Vol. 41, No. 3 ( 2007-06), p. 220-230
    Abstract: The composition of the aerosol and its physical and chemical characteristics affect the behavior of the aerosols and its effects on the chemistry of the atmosphere, the climate of the earth and the human health. Atmospheric particles originate either from anthropogenic or natural sources and are emitted into the atmosphere directly (primary particles), or are formed from inorganic trace gases or gaseous organic substances (secondary particles). As soon as particles are in air, they can change size, composition and concentration due to various processes. The most important processes are coagulation, gas particle distribution, particle phases chemistry (e.g. oxidation, polymerization) and deposition. Beside some inorganic trace components tropospheric particles consist generally of sulfate, nitrate, ammonium, metals, water as well as elemental carbon (EC) and organic carbon compounds (OC). Although substantial progress in the characterisation of aerosols was made in recent time, the knowledge of the characteristics and the composition of the aerosol particles is still relatively limited. This applies in particular to the composition of the organic fraction of the particles which has a strong influence on the physicochemical, climate and for health‐relevant characteristics of the particles.
    Type of Medium: Online Resource
    ISSN: 0009-2851 , 1521-3781
    URL: Issue
    URL: Article
    DOI: 10.1002/ciuz.v41:3
    DOI: 10.1002/ciuz.200700414
    RVK:
    WA 15000
    RVK:
    VA 1120
    RVK:
    VA 3275
    Language: English
    Publisher: Wiley
    Publication Date: 2007
    detail.hit.zdb_id: 2006650-8
    detail.hit.zdb_id: 6904-8
    Location Call Number Limitation Availability
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  • 2
    Online Resource
    Online Resource
    In vitro genotoxicity of dibutyl phthalate on A549 lung cells at air–liquid interface in exposure concentrations relevant at workplaces
    Wiley ; 2021
    In:  Environmental and Molecular Mutagenesis Vol. 62, No. 9 ( 2021-11), p. 490-501
    Details
    In: Environmental and Molecular Mutagenesis, Wiley, Vol. 62, No. 9 ( 2021-11), p. 490-501
    Abstract: The ubiquitous use of phthalates in various materials and the knowledge about their potential adverse effects is of great concern for human health. Several studies have uncovered their role in carcinogenic events and suggest various phthalate‐associated adverse health effects that include pulmonary diseases. However, only limited information on pulmonary toxicity is available considering inhalation of phthalates as the route of exposure. While in vitro studies are often based on submerged exposures, this study aimed to expose A549 alveolar epithelial cells at the air–liquid interface (ALI) to unravel the genotoxic and oxidative stress‐inducing potential of dibutyl phthalate (DBP) with concentrations relevant at occupational settings. Within this scope, a computer modeling approach calculating alveolar deposition of DBP particles in the human lung was used to define in vitro ALI exposure conditions comparable to potential occupational DBP exposures. The deposited mass of DBP ranged from 0.03 to 20 ng/cm 2 , which was comparable to results of a human lung particle deposition model using an 8 h workplace threshold limit value of 580 μg/m 3 proposed by the Scientific Committee on Occupational Exposure Limits for the European Union. Comet and Micronucleus assay revealed that DBP induced genotoxicity at DNA and chromosome level in sub‐cytotoxic conditions. Since genomic instability was accompanied by increased generation of the lipid peroxidation marker malondialdehyde, oxidative stress might play an important role in phthalate‐induced genotoxicity. The results highlight the importance of adapting in vitro studies to exposure scenarios relevant at occupational settings and reconsidering occupational exposure limits for DBP.
    Type of Medium: Online Resource
    ISSN: 0893-6692 , 1098-2280
    URL: Issue
    URL: Article
    DOI: 10.1002/em.v62.9
    DOI: 10.1002/em.22464
    RVK:
    WA 15000
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 1497682-1
    SSG: 12
    Location Call Number Limitation Availability
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