In:
PLOS Neglected Tropical Diseases, Public Library of Science (PLoS), Vol. 17, No. 9 ( 2023-9-22), p. e0011651-
Abstract:
Diagnosis of arbovirus infection or exposure by antibody testing is becoming increasingly difficult due to global expansion of arboviruses, which induce antibodies that may (cross-)react in serological assays. We provide a systematic review of the current knowledge and knowledge gaps in differential arbovirus serology. The search included Medline, Embase and Web of Science databases and identified 911 publications which were reduced to 102 after exclusion of studies not providing data on possible cross-reactivity or studies that did not meet the inclusion criteria regarding confirmation of virus exposure of reference population sets. Using a scoring system to further assess quality of studies, we show that the majority of the selected papers (N = 102) provides insufficient detail to support conclusions on specificity of serological outcomes with regards to elucidating antibody cross-reactivity. Along with the lack of standardization of assays, metadata such as time of illness onset, vaccination, infection and travel history, age and specificity of serological methods were most frequently missing. Given the critical role of serology for diagnosis and surveillance of arbovirus infections, better standards for reporting, as well as the development of more (standardized) specific serological assays that allow discrimination between exposures to multiple different arboviruses, are a large global unmet need.
Type of Medium:
Online Resource
ISSN:
1935-2735
DOI:
10.1371/journal.pntd.0011651
DOI:
10.1371/journal.pntd.0011651.g001
DOI:
10.1371/journal.pntd.0011651.g002
DOI:
10.1371/journal.pntd.0011651.g003
DOI:
10.1371/journal.pntd.0011651.g004
DOI:
10.1371/journal.pntd.0011651.g005
DOI:
10.1371/journal.pntd.0011651.g006
DOI:
10.1371/journal.pntd.0011651.g007
DOI:
10.1371/journal.pntd.0011651.t001
DOI:
10.1371/journal.pntd.0011651.t002
DOI:
10.1371/journal.pntd.0011651.t003
DOI:
10.1371/journal.pntd.0011651.s001
DOI:
10.1371/journal.pntd.0011651.s002
DOI:
10.1371/journal.pntd.0011651.s003
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2023
detail.hit.zdb_id:
2429704-5
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