In:
International Journal of Cancer, Wiley, Vol. 135, No. 11 ( 2014-12), p. 2507-2515
Kurzfassung:
What's New? The serrated neoplasia pathway has attracted considerable attention as an alternative route for colorectal cancer development. This study shows that high microRNA‐31 expression is associated with CpG island methylator phenotype (CIMP)‐high status in serrated lesions with BRAF mutation. The data also indicate that miR‐31 may play a role in sessile serrated adenoma evolution. Moreover, not only do BRAF mutation and CIMP‐high status increase gradually from the rectum to the caecum but high miR‐31 expression does, too, suggesting that miR‐31 is a key molecule in the colorectal continuum concept. These novel data shed light on details of the colorectal serrated pathway.
Materialart:
Online-Ressource
ISSN:
0020-7136
,
1097-0215
Sprache:
Englisch
Verlag:
Wiley
Publikationsdatum:
2014
ZDB Id:
218257-9
ZDB Id:
1474822-8
Permalink