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  • 1
    Online-Ressource
    Online-Ressource
    American Society of Civil Engineers (ASCE) ; 1983
    In:  Journal of Geotechnical Engineering Vol. 109, No. 5 ( 1983-05), p. 766-771
    In: Journal of Geotechnical Engineering, American Society of Civil Engineers (ASCE), Vol. 109, No. 5 ( 1983-05), p. 766-771
    Materialart: Online-Ressource
    ISSN: 0733-9410 , 1944-8368
    Sprache: Englisch
    Verlag: American Society of Civil Engineers (ASCE)
    Publikationsdatum: 1983
    ZDB Id: 2115958-0
    ZDB Id: 2011408-4
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 2
    In: Communications Biology, Springer Science and Business Media LLC, Vol. 5, No. 1 ( 2022-09-02)
    Kurzfassung: The process of identifying suitable genome-wide association (GWA) studies and formatting the data to calculate multiple polygenic risk scores on a single genome can be laborious. Here, we present a centralized polygenic risk score calculator currently containing over 250,000 genetic variant associations from the NHGRI-EBI GWAS Catalog for users to easily calculate sample-specific polygenic risk scores with comparable results to other available tools. Polygenic risk scores are calculated either online through the Polygenic Risk Score Knowledge Base (PRSKB; https://prs.byu.edu ) or via a command-line interface. We report study-specific polygenic risk scores across the UK Biobank, 1000 Genomes, and the Alzheimer’s Disease Neuroimaging Initiative (ADNI), contextualize computed scores, and identify potentially confounding genetic risk factors in ADNI. We introduce a streamlined analysis tool and web interface to calculate and contextualize polygenic risk scores across various studies, which we anticipate will facilitate a wider adaptation of polygenic risk scores in future disease research.
    Materialart: Online-Ressource
    ISSN: 2399-3642
    Sprache: Englisch
    Verlag: Springer Science and Business Media LLC
    Publikationsdatum: 2022
    ZDB Id: 2919698-X
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  • 3
    Online-Ressource
    Online-Ressource
    ASTM International ; 1999
    In:  Geotechnical Testing Journal Vol. 22, No. 1 ( 1999), p. 44-
    In: Geotechnical Testing Journal, ASTM International, Vol. 22, No. 1 ( 1999), p. 44-
    Materialart: Online-Ressource
    ISSN: 0149-6115
    Sprache: Englisch
    Verlag: ASTM International
    Publikationsdatum: 1999
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 4
    Online-Ressource
    Online-Ressource
    Thomas Telford Ltd. ; 2006
    In:  Geosynthetics International Vol. 13, No. 6 ( 2006-12), p. 246-264
    In: Geosynthetics International, Thomas Telford Ltd., Vol. 13, No. 6 ( 2006-12), p. 246-264
    Kurzfassung: The compressive strength of a soil bag pile when compressed vertically and the shear strength when sheared laterally were evaluated by performing a series of full-scale loading tests. The effects of soil bag material, backfill soil type, number of soil bags in a pile and associated effects of the end restraint at the top and bottom ends of a soil bag pile were evaluated. The results of vertical compression tests showed that initial compaction of the backfill in the soil bags is effective in increasing the initial stiffness at small deformation, and that preloading is even more effective in increasing the overall stiffness and decreasing the creep deformation. The shear strength of a soil bag pile subjected to lateral shear is substantially smaller as compared with a high compressive strength when compressed vertically. It was found that the shear strength of well-graded granular backfill was partially mobilised in vertical compression tests but the mobilisation was even lower in the lateral shear tests. The soil bag pile showed highly anisotropic strength characteristics, resulting from no or negligible complementary shear stresses acting at the vertical interface between the horizontally adjacent soil bags and highly anisotropic reinforcing effects of geosynthetic cover sheets of soil bags.
    Materialart: Online-Ressource
    ISSN: 1072-6349 , 1751-7613
    Sprache: Englisch
    Verlag: Thomas Telford Ltd.
    Publikationsdatum: 2006
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  • 5
    Online-Ressource
    Online-Ressource
    Thomas Telford Ltd. ; 2004
    In:  Geosynthetics International Vol. 11, No. 5 ( 2004-10), p. 390-405
    In: Geosynthetics International, Thomas Telford Ltd., Vol. 11, No. 5 ( 2004-10), p. 390-405
    Kurzfassung: A closed-form approximate solution, based on the stress characteristics method, for the compressive strength of a cohesionless soil mass reinforced with multiple horizontally arranged geosynthetic reinforcement layers subjected to vertical load through rigid platens is presented. It is assumed that the stress–strain properties of the backfill are isotropic perfectly plastic, the friction angle at the interface between the backfill and the reinforcement is uniform, and the effects of the weight of the backfill can be ignored. Assuming that the length/height ratio of the respective soil layer, sandwiched by reinforcement layers, is sufficiently large, then several other simplifications are introduced in the numerical procedures. The solution is compared with the results of plane strain compression tests using large specimens of air-dried Toyoura sand reinforced with multiple layers of a polymer geogrid. The equivalent friction angles at the interface between the sand and the geogrid, treated as a platen having a 100% coverage ratio, which were previously back-calculated using a non-linear FEM analysis by the author, were used in the present approximate analysis. It is shown that, with known values of the angle of friction of the backfill and the interface friction angle, the compressive strength of a given reinforced soil mass can be estimated reasonably well.
    Materialart: Online-Ressource
    ISSN: 1072-6349 , 1751-7613
    Sprache: Englisch
    Verlag: Thomas Telford Ltd.
    Publikationsdatum: 2004
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  • 6
    Online-Ressource
    Online-Ressource
    Thomas Telford Ltd. ; 2003
    In:  Geosynthetics International Vol. 10, No. 1 ( 2003-02), p. 2-23
    In: Geosynthetics International, Thomas Telford Ltd., Vol. 10, No. 1 ( 2003-02), p. 2-23
    Kurzfassung: Four geosynthetic-reinforced soil modular block (GRS-MB) retaining walls that behaved differently during the 1999 Taiwan Chi-Chi earthquake were investigated by field surveying and soil testing. Pseudo-static analyses based on the two-wedge failure mechanism were performed to investigate the seismic stability of such GRS-MB walls. The analyses considered the structural function of the stacked block facing and the contribution of reinforcement-facing connection strength to the seismic stability of GRS-MB retaining walls. It was found that the facing-reinforcement connection strength and the block–block shear resistance strongly affect the seismic stability and seismic displacement of GRS-MB retaining walls. Newmark's sliding block theory together with a ‘displacement diagram’ were used to evaluate the seismic displacements of the investigated walls. The displacement analyses give the values of horizontal seismic displacement of the discrete modular block facing and the vertical settlement of the backfill soil. It was found that the calculated values of wall displacements were comparable with the measured ones when the structural effects of the facing were properly accounted for. The effect of buckling mode deformation of the stacked blocks on the horizontal displacement of the GRS-MB walls is also evaluated quantitatively.
    Materialart: Online-Ressource
    ISSN: 1072-6349 , 1751-7613
    Sprache: Englisch
    Verlag: Thomas Telford Ltd.
    Publikationsdatum: 2003
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 7
    Online-Ressource
    Online-Ressource
    Thomas Telford Ltd. ; 2004
    In:  Geosynthetics International Vol. 11, No. 2 ( 2004-04), p. 73-99
    In: Geosynthetics International, Thomas Telford Ltd., Vol. 11, No. 2 ( 2004-04), p. 73-99
    Kurzfassung: To evaluate the deformation characteristics of geosynthetic reinforcement under cyclic loading conditions, a series of tensile loading tests were performed on three types of polymer geogrid and one type of geocomposite using a wide variety of loading histories, including cyclic loading and sustained loading applied during otherwise monotonic loading. In order to separate the loading rate effects due to viscous properties from the rate-independent cyclic loading effects, cyclic loading was applied at five different frequencies for the same total period of cyclic loading at several base loads using two different load amplitudes. It is shown that the residual strain that develops during a given cyclic loading history is controlled essentially by the total period of cyclic loading, whereas it is independent of loading frequency (i.e. independent of the number of loading cycles). That is, the residual strain that develops during a given cyclic loading history is due mostly to the intrinsic viscous properties of the respective geosynthetic reinforcement type. The whole relationship between the tensile load and the tensile strain measured from the start to the end of the respective test, which consisted of monotonic loading and cyclic or sustained loading or both, was successfully simulated by a non-linear three-component rheology model with parameters that do not incorporate any rate-independent cyclic loading effects.
    Materialart: Online-Ressource
    ISSN: 1072-6349 , 1751-7613
    Sprache: Englisch
    Verlag: Thomas Telford Ltd.
    Publikationsdatum: 2004
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 8
    Online-Ressource
    Online-Ressource
    Thomas Telford Ltd. ; 2009
    In:  Geosynthetics International Vol. 16, No. 4 ( 2009-08), p. 301-326
    In: Geosynthetics International, Thomas Telford Ltd., Vol. 16, No. 4 ( 2009-08), p. 301-326
    Kurzfassung: ABSTRACT: Integral bridges, comprising a continuous bridge girder (i.e. deck) integrated to a pair of abutments without using hinged and movable shoes (i.e. bearings), have been constructed to alleviate several inherent drawbacks of conventional bridges. It is shown that this conventional type of integral bridge still has the following problems: (1) large residual settlements in the backfill, developing a bump immediately behind the abutments, and the development of high residual earth pressure on the back of the abutments by seasonal thermal expansion and contraction of the girder, as well as by traffic loads on the backfill; and (2) large detrimental deformation of the backfill by seismic loads. To alleviate these problems, it is proposed to reinforce the backfill with geosynthetic reinforcement that is firmly connected to the full-height rigid facings (i.e. abutments). A newly proposed integral bridge, called the GRS integral bridge, is constructed in stages: first, geosynthetic-reinforced backfill; second, pile foundations (if necessary); third, full-height rigid (FHR) facings (i.e. abutments); and finally a continuous girder integrated to the top of the two abutments, without using shoes. A series of static cyclic loading tests, laterally on the facing and vertically on the crest of the backfill, and shaking-table tests were performed on models of the conventional and new types of integral bridge, as well as two conventional bridge types comprising RC gravity-type abutments and geosynthetic-reinforced soil-retaining walls, both supporting a girder via shoes. The test results showed high static and dynamic performance of the GRS integral bridge, despite its simple structure and construction procedure, and therefore its low construction cost.
    Materialart: Online-Ressource
    ISSN: 1072-6349 , 1751-7613
    Sprache: Englisch
    Verlag: Thomas Telford Ltd.
    Publikationsdatum: 2009
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  • 9
    Online-Ressource
    Online-Ressource
    ASTM International ; 1993
    In:  Geotechnical Testing Journal Vol. 16, No. 1 ( 1993), p. 3-
    In: Geotechnical Testing Journal, ASTM International, Vol. 16, No. 1 ( 1993), p. 3-
    Materialart: Online-Ressource
    ISSN: 0149-6115
    Sprache: Englisch
    Verlag: ASTM International
    Publikationsdatum: 1993
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 10
    Online-Ressource
    Online-Ressource
    ASTM International ; 1999
    In:  Geotechnical Testing Journal Vol. 22, No. 1 ( 1999), p. 80-
    In: Geotechnical Testing Journal, ASTM International, Vol. 22, No. 1 ( 1999), p. 80-
    Materialart: Online-Ressource
    ISSN: 0149-6115
    Sprache: Englisch
    Verlag: ASTM International
    Publikationsdatum: 1999
    Standort Signatur Einschränkungen Verfügbarkeit
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