In:
Pathology International, Wiley, Vol. 50, No. 10 ( 2000-10), p. 793-800
Abstract:
To clarify the clinicopathological features of an atypical cystic duct (ACD) as defined by Tsuchiya’s criteria as a precancerous lesion of the breast, we used 200 whole mammary gland serial sections of breast cancer. Forty‐four (22%) of the 200 breast cancer patients had ACD breast lesions. The frequency of patients with ACD increased in premenopausal women ( P = 0.001). There was no correlation between the ACD‐present group and the ACD‐absent group for immunohistochemical status of the estrogen receptor (ER), progesterone receptor (PgR), p53, or c‐erbB2; Ki‐67 labeling index of cancer tissues; size of tumor, or lymph node metastases. A number of ACD lesions displayed continuity to cancer lesions. In 500 serial sections of a paraffin‐embedded tissue of a ACD case at 3 μm intervals, an apparent transition from ACD into ductal carcinoma in situ was observed. Immunohistochemical analysis using α ‐smooth muscle actin showed that myoepithelial cells of ACD stained strongly, and their nuclei and cytoplasm were thinning. In 16 of the 44 (36%) ACD‐present patients, carcinoma cells stained positive for p53. Within those 16 cases, 12 cases (75%) were positive for p53 in ACD lesions. There was a significant correlation between the expression of p53 protein in malignant cells and ACD ( P = 0.001). All 44 ACD lesions had no staining of c‐erbB2, regardless of staining in malignant lesions. The mean Ki‐67 labeling index of ACD lesions was low (0.3%), suggesting that ACD had a low proliferative rate. We suggest that ACD is the precancerous breast lesion because of a histologic continuum between ACD and malignancy, and because of p53 protein expression in ACD.
Type of Medium:
Online Resource
ISSN:
1320-5463
,
1440-1827
DOI:
10.1046/j.1440-1827.2000.01121.x
Language:
English
Publisher:
Wiley
Publication Date:
2000
detail.hit.zdb_id:
2008574-6
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