In:
PLOS ONE, Public Library of Science (PLoS), Vol. 17, No. 12 ( 2022-12-13), p. e0277729-
Abstract:
This study evaluated the associations of liver fibrosis biomarkers [non-alcoholic fatty liver disease fibrosis score (NFS), fibrosis-4 (FIB-4), aspartate aminotransferase/platelet ratio index (APRI), and BARD score] with mortality in Korean adults aged ≥50 years. We analyzed 7,702 subjects who participated in Dong-gu Study. The associations of liber fibrosis biomarkers with mortality were investigated using Cox proportional hazards models. Overall mortality increased with increasing NFS level [adjusted hazard ratio (aHR) 4.3, 95% confidence interval (CI) 3.3–5.5 for high risk vs. low risk] , increasing FIB-4 level (aHR 3.5, 95% CI 2.9–4.4 for high risk vs. low risk), and increasing APRI level (aHR 3.5, 95% CI 2.1–5.8 for high risk vs. low risk) but not with BARD score. The Harrell’s concordance index for overall mortality for the NFS and FIB-4 was greater than that for the APRI and BARD score. In conclusion, NFS, FIB-4, and APRI showed a significant relationship with the overall mortality, and NFS and FIB-4 showed a significant relationship with the CVD mortality after adjustment for covariates. In addition, the NFS and FIB-4 were more predictive of overall mortality than the APRI and BARD score in Korean adults aged ≥50 years.
Type of Medium:
Online Resource
ISSN:
1932-6203
DOI:
10.1371/journal.pone.0277729
DOI:
10.1371/journal.pone.0277729.g001
DOI:
10.1371/journal.pone.0277729.g002
DOI:
10.1371/journal.pone.0277729.t001
DOI:
10.1371/journal.pone.0277729.t002
DOI:
10.1371/journal.pone.0277729.t003
DOI:
10.1371/journal.pone.0277729.t004
DOI:
10.1371/journal.pone.0277729.s001
DOI:
10.1371/journal.pone.0277729.r001
DOI:
10.1371/journal.pone.0277729.r002
DOI:
10.1371/journal.pone.0277729.r003
DOI:
10.1371/journal.pone.0277729.r004
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2022
detail.hit.zdb_id:
2267670-3
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