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  • 1
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    Online Resource
    Genome‐wide identification and characterization of macrolide glycosyltransferases from a marine‐derived Bacillus strain and their phylogenetic distribution
    Wiley ; 2016
    In:  Environmental Microbiology Vol. 18, No. 12 ( 2016-12), p. 4770-4781
    Details
    In: Environmental Microbiology, Wiley, Vol. 18, No. 12 ( 2016-12), p. 4770-4781
    Abstract: Clarifying glycosyltrasferases (GTs) function is of significance for the development of GT inhibitors as drugs, and the use of GTs to glycodiversify small molecules in the search of drug leads. While many Actinomyces natural‐product GTs had been functionally characterized, our understanding towards Bacillus natural‐product GTs is so far very limited. Herein, genome‐wide identification of macrolide GT genes from marine‐derived Bacillus methylotrophicus B‐9987 revealed the presence of three macrolide GT genes bmmGT1 −3. While bmmGT1 was previously revealed to be involved in the biosynthesis of trans ‐acyltransferase (AT) polyketides compounds macrolactins (MLNs) and bacillaenes (BAEs), the functions of bmmGT2 and bmmGT3 were probed, demonstrating that they are capable to biochemically catalyze glycosylation of MLNs and BAEs as well but interestingly with different regioselectivity, affording four new MLNs analogs. Notably, further genome mining revealed that the orthologs of these three macrolide GT genes showed a regular distribution in the subtilis ‐ and the cereus ‐clade Bacillus strains; interestingly, bmmGT1 orthologs only occurred in the subtilis ‐clade Bacillus , and they were also found in the genomes of Streptomyces strains, suggesting their close phylogenetic relationship. These results provide the first significant insight into the important roles of Bacillus macrolide GTs in the biology of the species.
    Type of Medium: Online Resource
    ISSN: 1462-2912 , 1462-2920
    URL: Issue
    URL: Article
    DOI: 10.1111/emi.2016.18.issue-12
    DOI: 10.1111/1462-2920.13367
    Language: English
    Publisher: Wiley
    Publication Date: 2016
    detail.hit.zdb_id: 2020213-1
    SSG: 12
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  • 2
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    Small kernel 501 ( smk501 ) encodes the RUBylation activating enzyme E1 subunit ECR1 (E1 C‐TERMINAL RELATED 1) and is essential for multiple aspects of cellular events during kernel development in maize
    Wiley ; 2021
    In:  New Phytologist Vol. 230, No. 6 ( 2021-06), p. 2337-2354
    Details
    In: New Phytologist, Wiley, Vol. 230, No. 6 ( 2021-06), p. 2337-2354
    Abstract: RUBylation plays essential roles in plant growth and development through regulating Cullin‐RING ubiquitin E3 ligase (CRL) activities and the CRL‐mediated protein degradations. However, the function of RUBylation in regulating kernel development remains unclear. Through genetic and molecular analyses of a small kernel 501 ( smk501 ) mutant in maize ( Zea mays ), we cloned the smk501 gene, revealed its molecular function, and defined its roles in RUBylation pathway and seed development. Smk501 encodes a RUBylation activating enzyme E1 subunit ZmECR1 (E1 C‐TERMINAL RELATED 1) protein. Destruction in RUBylation by smk501 mutation resulted in less embryo and endosperm cell number and smaller kernel size. The transcriptome and proteome profiling, hormone evaluation and cell proliferation observation revealed that disturbing ZmECR1 expression mainly affects pathways on hormone signal transduction, cell cycle progression and starch accumulation during kernel development. In addition, mutant in zmaxr1 (Auxin resistant 1), another RUB E1 subunit, also showed similar defects in kernel development. Double mutation of zmecr1 and zmaxr1 lead to empty pericarp kernel phenotype. RUBylation is a novel regulatory pathway affecting maize kernel development, majorly through its functions in modifying multiple cellular progresses.
    Type of Medium: Online Resource
    ISSN: 0028-646X , 1469-8137
    URL: Issue
    URL: Article
    DOI: 10.1111/nph.v230.6
    DOI: 10.1111/nph.17354
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 208885-X
    detail.hit.zdb_id: 1472194-6
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  • 3
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    Characterization and Identification of Single Nucleotide Polymorphism Within the IGF‐1R Gene Associated with Growth Traits of Odontobutis potamophila
    Wiley ; 2018
    In:  Journal of the World Aquaculture Society Vol. 49, No. 2 ( 2018-04), p. 366-379
    Details
    In: Journal of the World Aquaculture Society, Wiley, Vol. 49, No. 2 ( 2018-04), p. 366-379
    Abstract: IGF‐1R plays a critical role in many physiological activities, such as development, growth, metabolism, and reproduction. Identification of genetic markers in the IGF‐1R gene significantly associated with important growth traits of Odontobutis potamophila may accelerate genetic improvement. In this study, we characterized the cDNA sequence of the IGF‐1R gene of O. potamophila , and our data revealed that IGF‐1R contained an open reading frame of 1650 bp, encoding a polypeptide of 549 amino acids (aa). Quantitative real‐time polymerase chain reaction demonstrated that IGF‐1R was ubiquitously expressed in all tested tissues, and the most predominant expression of IGF‐1R was detected in gonad. Moreover, IGF‐1R was expressed at different developmental stages from embryo to larva, and its highest expression level was found at the morula stage. In addition, we identified three single nucleotide polymorphisms (SNPs; 1777T 〉 C, 1704G 〉 A, and 1208G 〉 A) within IGF‐1R locus and found that one SNP (1208G 〉 A) was significantly associated with important growth traits of O. potamophila . Results showed that the overall length, body length, trunk width, caudal peduncle length, body weight, and body width in fish with AG genotype were significantly greater compared with those with GG genotype ( P 〈 0.05). However, the other two SNPs (1777T 〉 C and 1704G 〉 A) did not show significant associations with any growth traits. Therefore, SNPs within the IGF‐1R locus could be used as a selection criterion to improve growth traits of O. potamophila .
    Type of Medium: Online Resource
    ISSN: 0893-8849 , 1749-7345
    URL: Issue
    URL: Article
    DOI: 10.1111/jwas.2018.49.issue-2
    DOI: 10.1111/jwas.12504
    Language: English
    Publisher: Wiley
    Publication Date: 2018
    detail.hit.zdb_id: 2233509-2
    SSG: 21,3
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  • 4
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    Alterations of the Human Gut Microbiome in Chronic Kidney Disease
    Wiley ; 2020
    In:  Advanced Science Vol. 7, No. 20 ( 2020-10)
    Details
    In: Advanced Science, Wiley, Vol. 7, No. 20 ( 2020-10)
    Abstract: Gut microbiota make up the largest microecosystem in the human body and are closely related to chronic metabolic diseases. Herein, 520 fecal samples are collected from different regions of China, the gut microbiome in chronic kidney disease (CKD) is characterized, and CKD classifiers based on microbial markers are constructed. Compared with healthy controls (HC, n = 210), gut microbial diversity is significantly decreased in CKD ( n = 110), and the microbial community is remarkably distinguished from HC. Genera Klebsiella and Enterobacteriaceae are enriched, while Blautia and Roseburia are reduced in CKD. Fifty predicted microbial functions including tryptophan and phenylalanine metabolisms increase, while 36 functions including arginine and proline metabolisms decrease in CKD. Notably, five optimal microbial markers are identified using the random forest model. The area under the curve (AUC) reaches 0.9887 in the discovery cohort and 0.9512 in the validation cohort (49 CKD vs 63 HC). Importantly, the AUC reaches 0.8986 in the extra diagnosis cohort from Hangzhou. Moreover, Thalassospira and Akkermansia are increased with CKD progression. Thirteen operational taxonomy units are correlated with six clinical indicators of CKD. In conclusion, this study comprehensively characterizes gut microbiome in non‐dialysis CKD and demonstrates the potential of microbial markers as non‐invasive diagnostic tools for CKD in different regions of China.
    Type of Medium: Online Resource
    ISSN: 2198-3844 , 2198-3844
    URL: Issue
    URL: Article
    DOI: 10.1002/advs.v7.20
    DOI: 10.1002/advs.202001936
    Language: English
    Publisher: Wiley
    Publication Date: 2020
    detail.hit.zdb_id: 2808093-2
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  • 5
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    Metasurface‐Enabled High‐Resolution Liquid‐Crystal Alignment for Display and Modulator Applications
    Wiley ; 2022
    In:  Laser & Photonics Reviews Vol. 16, No. 1 ( 2022-01)
    Details
    In: Laser & Photonics Reviews, Wiley, Vol. 16, No. 1 ( 2022-01)
    Abstract: Optical metasurfaces are 2D flat elements that consist of spatially arranged meta‐atoms. By carefully designing the metasurface, it is possible to fully control the properties of light in amplitude, phase, and/or polarization. When merged with liquid crystals (LCs), a metasurface can act as a reconfigurable optical component enabling dynamical control of light. However, many reports ignore the influence of the meta‐atom's geometry on the orientation of LCs. Here, it is proposed to synergistically merge LCs and specially designed gold metasurfaces for multiple optical functions. Gold metasurfaces are designed as a template to align the LC molecules in a resolution of ≤2 µm. Meanwhile, the aligned LCs are used to actively control the polarization of the incident light, further achieving active modulation of the plasmonic resonances of gold metasurfaces. The synergistic mergence of LCs and metasurfaces can enable a designed optical device to work simultaneously in both visible and near infrared ranges, which is highly promising for multiple applications simultaneously, such as high‐resolution display, modulation, anti‐counterfeiting, beam deflection, LiDAR, etc.
    Type of Medium: Online Resource
    ISSN: 1863-8880 , 1863-8899
    URL: Issue
    URL: Article
    DOI: 10.1002/lpor.v16.1
    DOI: 10.1002/lpor.202100396
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 2266512-2
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  • 6
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    ChemInform Abstract: Amino Acid Salt Catalyzed Asymmetric Synthesis of 1,2-Diols with a Quaternary Carbon Center.
    Wiley ; 2016
    In:  ChemInform Vol. 47, No. 7 ( 2016-01), p. no-no
    Details
    In: ChemInform, Wiley, Vol. 47, No. 7 ( 2016-01), p. no-no
    Type of Medium: Online Resource
    ISSN: 0931-7597
    URL: Article
    DOI: 10.1002/chin.201607103
    Language: English
    Publisher: Wiley
    Publication Date: 2016
    detail.hit.zdb_id: 2110203-X
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  • 7
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    Double‐flow convolutional neural network for rapid large field of view Fourier ptychographic reconstruction
    Wiley ; 2021
    In:  Journal of Biophotonics Vol. 14, No. 6 ( 2021-06)
    Details
    In: Journal of Biophotonics, Wiley, Vol. 14, No. 6 ( 2021-06)
    Abstract: Fourier ptychographic microscopy is a promising imaging technique which can circumvent the space‐bandwidth product of the system and achieve a reconstruction result with wide field‐of‐view (FOV), high‐resolution and quantitative phase information. However, traditional iterative‐based methods typically require multiple times to get convergence, and due to the wave vector deviation in different areas, the millimeter‐level full‐FOV cannot be well reconstructed once and typically required to be separated into several portions with sufficient overlaps and reconstructed separately, which makes traditional methods suffer from long reconstruction time for a large‐FOV (of the order of minutes) and limits the application in real‐time large‐FOV monitoring of live sample in vitro. Here we propose a novel deep‐learning based method called DFNN which can be used in place of traditional iterative‐based methods to increase the quality of single large‐FOV reconstruction and reducing the processing time from 167.5 to 0.1125 second. In addition, we demonstrate that by training based on the simulation dataset with high‐entropy property (Opt. Express 28, 24 152 [2020]), DFNN could has fine generalizability and little dependence on the morphological features of samples. The superior robustness of DFNN against noise is also demonstrated in both simulation and experiment. Furthermore, our model shows more robustness against the wave vector deviation. Therefore, we could achieve better results at the edge areas of a single large‐FOV reconstruction. Our method demonstrates a promising way to perform real‐time single large‐FOV reconstructions and provides further possibilities for real‐time large‐FOV monitoring of live samples with sub‐cellular resolution.
    Type of Medium: Online Resource
    ISSN: 1864-063X , 1864-0648
    URL: Issue
    URL: Article
    DOI: 10.1002/jbio.v14.6
    DOI: 10.1002/jbio.202000444
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 2403788-6
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  • 8
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    Childhood overweight and obesity: age stratification contributes to the differences in metabolic characteristics
    Wiley ; 2023
    In:  Obesity
    Details
    In: Obesity, Wiley
    Abstract: The aim of this study was to identify the differential metabolic characteristics of children with overweight and obesity and understand their potential mechanism in different age stratifications. Methods Four hundred seventy‐three children were recruited and divided into two age stratifications: 〉 4 years (older children) and ≤4 years (younger children), and overweight and obesity were defined according to their BMI percentile. A one dimensional proton nuclear magnetic resonance ( 1 H‐NMR)–based metabolomics strategy combined with pattern recognition methods was used to identify the metabolic characteristics of childhood overweight and obesity. Results Four and sixteen potential biomarkers related to overweight and two and twenty potential biomarkers related to obesity were identified from younger and older children, respectively. Fluctuations in phenylalanine, tyrosine, glutamine, leucine, histidine, and ascorbate co‐occurred in children with obesity at two age stratifications. The disturbances in biosynthesis and metabolism of amino acids, lipid metabolism, and galactose metabolism disturbance were mainly involved in children with overweight and obesity. Conclusions The metabolic disturbances show a significant progression from overweight to obesity in children, and different metabolic characteristics were demonstrated in age stratifications. The changes in the levels of phenylalanine, tyrosine, glutamine, leucine, histidine, and ascorbate were tracked with the persistence of childhood obesity. These findings will promote the mechanistic understanding of childhood overweight and obesity.
    Type of Medium: Online Resource
    ISSN: 1930-7381 , 1930-739X
    URL: Article
    DOI: 10.1002/oby.23964
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2027211-X
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  • 9
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    Polymerizable Deep Eutectic Solvent‐Based Skin‐Like Elastomers with Dynamic Schemochrome and Self‐Healing Ability
    Wiley ; 2022
    In:  Small Vol. 18, No. 19 ( 2022-05)
    Details
    In: Small, Wiley, Vol. 18, No. 19 ( 2022-05)
    Abstract: Animal skin is a huge source of inspiration when it comes to multifunctional sensing materials. Bioinspired sensors integrated with the intriguing performance of skin‐like steady wide‐range strain detection, real‐time dynamic visual cues, and self‐healing ability hold great promise for next‐generation electronic skin materials. Here, inspired by the skins of a chameleon, cellulose nanocrystals (CNCs) liquid crystal skeleton is embedded into polymerizable deep eutectic solvent (PDES) via in situ polymerization to develop a skin‐like elastomer. Benefiting from the elastic ionic conductive PDES matrix and dynamic interfacial hydrogen bonding, this strategy has broken through the limitations that CNCs‐based cholesteric structure is fragile and its helical pitch is non‐adjustable, endowing the resulting elastomer with strain‐induced wide‐range (0–500%) dynamic structural colors and excellent self‐healing ability (78.9–90.7%). Furthermore, the resulting materials exhibit high stretch‐ability (1163.7%), strain‐sensing and self‐adhesive abilities, which make them well‐suitable for developing widely applicable and highly reliable flexible sensors. The proposed approach of constructing biomimetic skin‐like materials with wide‐range dynamic schemochrome is expected to extend new possibilities in diverse applications including anti‐counterfeit labels, soft foldable displays, and wearable optical devices.
    Type of Medium: Online Resource
    ISSN: 1613-6810 , 1613-6829
    URL: Issue
    URL: Article
    DOI: 10.1002/smll.v18.19
    DOI: 10.1002/smll.202201012
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 2168935-0
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  • 10
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    Thinopyrum intermedium TiAP1 interacts with a chitin deacetylase from Blumeria graminis f. sp. tritici and increases the resistance to Bgt in wheat
    Wiley ; 2022
    In:  Plant Biotechnology Journal Vol. 20, No. 3 ( 2022-03), p. 454-467
    Details
    In: Plant Biotechnology Journal, Wiley, Vol. 20, No. 3 ( 2022-03), p. 454-467
    Abstract: The biotrophic fungal pathogen Blumeria graminis f. sp. tritici ( Bgt ) is a crucial factor causing reduction in global wheat production. Wild wheat relatives, for example Thinopyrum intermedium , is one of the wild‐used parents in wheat disease‐resistant breeding. From T .  intermedium line, we identified the aspartic protease gene, TiAP1 , which is involved in resistance against Bgt . TiAP1 is a secreted protein that accumulates in large amounts at the infection sites of Bgt and extends to the intercellular space. Yeast two‐hybrid, luciferase complementation imaging and bimolecular florescent complimentary analysis showed that TiAP1 interacted with the chitin deacetylase (BgtCDA1) of Bgt . The yeast expression, purification and in vitro test confirmed the chitin deacetylase activity of BgtCDA1. The bombardment and VIGS‐mediated host‐induced gene silencing showed that BgtCDA1 promotes the invasion of Bgt . Transcriptome analysis showed the cell wall xylan metabolism, lignin biosynthesis‐related and defence genes involved in the signal transduction were up‐regulated in the transgenic TiAP1 wheat induced by Bgt . The TiAP1 in wheat may inactivate the deacetylation function of BgtCDA1, cause chitin oligomers expose to wheat chitin receptor, then trigger the wheat immune response to inhibit the growth and penetration of Bgt , and thereby enhance the resistance of wheat to pathogens.
    Type of Medium: Online Resource
    ISSN: 1467-7644 , 1467-7652
    URL: Issue
    URL: Article
    DOI: 10.1111/pbi.v20.3
    DOI: 10.1111/pbi.13728
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 2136367-5
    SSG: 12
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