In:
European Journal of Organic Chemistry, Wiley, Vol. 2014, No. 26 ( 2014-09), p. 5728-5734
Abstract:
New immunosuppressants are needed to assist therapeutic efforts to manage immunological diseases. Along with known compounds 1 – 4 , new diterpenes myrocin E ( 5 ), libertellenone J ( 6 ) and libertellenone K ( 7 ) were isolated from the culture of Phomopsis sp. S12, from the apparently normal seed of Illigera rhodantha (Hernandiaceae). The structures were elucidated by a combination of spectroscopic and computational approaches, in conjunction with the low‐temperature (100 K) single‐crystal X‐ray diffraction with copper K α radiation. Libertellenone J ( 6 ) was shown to reduce significantly the production of NO, IL‐1β, IL‐6 and TNF‐α with an IC 50 range of 2.2–10.2 μ M , and to decrease the levels of iNOS, IL‐1β, IL‐6 and TNF‐α mRNA expression in lipopolysaccharide‐activated macrophages with IC 50 values of 3.5–15.2 μ M . These significant results may inspire the development of new immunosuppressive agents.
Type of Medium:
Online Resource
ISSN:
1434-193X
,
1099-0690
DOI:
10.1002/ejoc.v2014.26
DOI:
10.1002/ejoc.201402491
Language:
English
Publisher:
Wiley
Publication Date:
2014
detail.hit.zdb_id:
1475010-7
Permalink