In:
Journal of Intensive Care Medicine, SAGE Publications, Vol. 35, No. 9 ( 2020-09), p. 881-888
Abstract:
Vasopressin is used in conjunction with norepinephrine during treatment of patients with septic shock. Serum lactate is often used in monitoring of patients with sepsis; however, its importance as a therapeutic target is unclear. The objective of this study is to examine the relationship of vasopressin use on serum lactate levels in patients with sepsis. Methods: This study uses electronic heath records available via the Medical Information Mart for Intensive Care III. Patients were required to have a serum lactate monitoring during the intensive care unit (ICU) stay. The treatment was the administration of vasopressin between hours 3 and 18 of the ICU stay. Analysis was performed using a matched design. Results: Patients receiving vasopressin were more likely to have their serum lactate levels rise when compared to matched patients who did not receive vasopressin (odds ratio: 6.6; 95% confidence interval: 3.0-14.6, P 〈 .001). Patients who received vasopressin had a median increase in serum lactate of 0.3 mmol/L, while patients who did not receive vasopressin had a median decrease in serum lactate of 0.7 mmol/L ( P 〈 .001). There was no statistically significant difference between the control and treated groups’ lactate trajectories prior to possible administration of vasopressin ( P = .15). The results did not change significantly when norepinephrine initiation was used as the index time. Conclusions: In patients with sepsis, the administration of vasopressin was associated with a statistically significant difference in lactate change over the course of 24 hours when compared to matched patients who did not receive vasopressin.
Type of Medium:
Online Resource
ISSN:
0885-0666
,
1525-1489
DOI:
10.1177/0885066618794925
Language:
English
Publisher:
SAGE Publications
Publication Date:
2020
detail.hit.zdb_id:
2001472-7
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