In:
Nephron, S. Karger AG, Vol. 145, No. 5 ( 2021), p. 481-485
Abstract:
〈 b 〉 〈 i 〉 Introduction: 〈 /i 〉 〈 /b 〉 Low serum testosterone is related to increased mortality in male dialysis patients. An association of vitamin D status with serum androgen levels with concordant seasonal variation has been described, but it is undecided whether vitamin D supplementation improves testosterone levels. 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 In a randomized, placebo-controlled, and double-blind manner, we investigated the effects of an oral vitamin D supplementation in healthy subjects and hemodialysis patients on testosterone levels. One hundred three healthy individuals received cholecalciferol 800 IE/day ( 〈 i 〉 n 〈 /i 〉 = 52) or placebo ( 〈 i 〉 n 〈 /i 〉 = 51) for 12 weeks. Thirty-three hemodialysis patients received cholecalciferol adapted to their serum levels following current guidelines ( 〈 i 〉 n 〈 /i 〉 = 15) or placebo ( 〈 i 〉 n 〈 /i 〉 = 18) for 12 weeks. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 In healthy individuals, 25(OH)D3 levels rose significantly in the verum group (38.1 ± 13.7 vs. 72.5 ± 15.4 nmol/L, 〈 i 〉 p 〈 /i 〉 & #x3c; 0.001), whereas in the placebo group, levels dropped (37.7 ± 14.7 vs. 31.9 ± 13.1, 〈 i 〉 p 〈 /i 〉 & #x3c; 0.001). Testosterone levels did not change significantly (verum, males: 20.9 ± 6.6 vs. 20.5 ± 7.9 nmol/L, 〈 i 〉 p 〈 /i 〉 = 0.6; verum, females: 0.9 ± 0.5 vs. 0.92 ± 0.5, 〈 i 〉 p 〈 /i 〉 = 0.4; placebo, males: 18.5 ± 10.2 vs. 21.8 ± 16.5, 〈 i 〉 p 〈 /i 〉 = 0.07, placebo, females: 1.6 ± 4.2 vs. 1.6 ± 4.9, 〈 i 〉 p 〈 /i 〉 = 0.6). In dialysis patients, the mean cholecalciferol level was only 32.3 ± 17.8 nmol/L, with only 2% of the values being within the normal range. Cholecalciferol levels normalized in the verum group (29.4 ± 11.2 vs. 87.8 ± 22.3, 〈 i 〉 p 〈 /i 〉 & #x3c; 0.001), whereas levels dropped further in the placebo group (33.6 ± 16.6 vs. 24.6 ± 8.0 nmol/L, 〈 i 〉 p 〈 /i 〉 & #x3c; 0.001). Testosterone levels did not change significantly (verum, males: 8.0 ± 3.7 vs. 7.8 ± 3.8, 〈 i 〉 p 〈 /i 〉 = 0.8; verum, females: 1.3 ± 1.0 vs. 1.2 ± 1.0 nmol/L, 〈 i 〉 p 〈 /i 〉 = 0.5; placebo, males: 11.9 ± 5.0 vs. 11.6 ± 4.0 nmol/L, 〈 i 〉 p 〈 /i 〉 = 0.6; placebo, females: 0.8 ± 0.5 vs. 0.7 ± 0.4 nmol/L, 〈 i 〉 p 〈 /i 〉 = 0.8). 〈 b 〉 〈 i 〉 Conclusion: 〈 /i 〉 〈 /b 〉 Serum testosterone levels in hemodialysis patients and healthy individuals are independent from vitamin D status and cannot be significantly increased by cholecalciferol supplementation.
Type of Medium:
Online Resource
ISSN:
1660-8151
,
2235-3186
Language:
English
Publisher:
S. Karger AG
Publication Date:
2021
detail.hit.zdb_id:
2810853-X
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