In:
Asian Cardiovascular and Thoracic Annals, SAGE Publications, Vol. 20, No. 4 ( 2012-08), p. 398-403
Abstract:
Objectives: a history of myeloproliferative neoplasms is considered to increase the risks in cardiac surgery. In patients with myeloproliferative neoplasms, increased rates of perioperative infections and thromboembolic complications are suspected, but studies analyzing the impact of myeloproliferative neoplasms on results after cardiac surgery are lacking. Methods: 13 patients with the diagnosis of myeloproliferative neoplasm underwent cardiac surgery. These patients were matched to 36 controls. Matching criteria consisted of sex, age, diagnosis, and comorbidities. Patients were analyzed regarding laboratory parameters, blood transfusion demands, morbidity, and mortality. Results: compared to controls, patients with myeloproliferative neoplasms demonstrated a significantly lower body-mass index ( p 〈 0.01), creatinine ( p = 0.024), prothrombin time ( p = 0.001), and urea level ( p = 0.012). The perioperative leukocyte response ( p = 0.03) was ameliorated, and platelet counts ( p 〈 0.02) increased. Patients with myeloproliferative neoplasms had a reduced need for erythrocyte concentrates (54% vs. 86%, p = 0.047) but increased need for plasma and thrombocytes (15% vs. 0%, p = 0.07). Patients with myeloproliferative neoplasms had a significantly increased incidence of thromboembolic events compared to controls (31% vs. 3%, p = 0.014). Hospital mortality remained at zero, but mid-term survival was lower in patients with myeloproliferative neoplasms ( p = 0.078). Conclusions: myeloproliferative neoplasm as a concomitant diagnosis increases the risk of thromboembolic complications during cardiac surgery. Plasma and platelet substitutions have to be administered, although strokes were not associated with hemostatic treatment.
Type of Medium:
Online Resource
ISSN:
0218-4923
,
1816-5370
DOI:
10.1177/0218492312438562
Language:
English
Publisher:
SAGE Publications
Publication Date:
2012
detail.hit.zdb_id:
2044527-1
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