In:
Statistics in Medicine, Wiley, Vol. 39, No. 8 ( 2020-04-15), p. 1183-1198
Abstract:
There are many settings where individual person data (IPD) are not available, due to privacy or technical reasons, and one must work with IPD proxies, such as summary statistics, to approximate original IPD inferences, that is, the results of statistical analyses that would ideally have been performed on individual‐level data. For instance, in a distributed computing setting, as implemented in the DataSHIELD software framework, different centers can only share IPD proxies to obtain pooled IPD inferences. Such privacy requirements limit the scope of statistical investigation. For example, it can be challenging to perform between‐center random‐effect regression models. To increase modeling freedom we propose a method that only uses simple nondisclosive summaries of the original IPD as input, such as empirical marginal moments and correlation matrices, and generates artificial data compatible with those summary features. Specifically, data are generated from a Gaussian copula with marginal and joint components specified by the above summaries. The goal is to reproduce original IPD features in the artificial data, such that original IPD inferences are recovered from the artificial data. In an application example, and through simulations, we show that we can recover estimates of a multivariable IPD random‐effect logistic regression, from artificial data generated via the Gaussian copula using the above IPD summaries, suggesting the proposed approach provides a generally applicable strategy for distributed computing settings with data protection constraints.
Type of Medium:
Online Resource
ISSN:
0277-6715
,
1097-0258
Language:
English
Publisher:
Wiley
Publication Date:
2020
detail.hit.zdb_id:
1491221-1
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