In:
FEBS Letters, Wiley, Vol. 324, No. 1 ( 1993-06-07), p. 63-66
Abstract:
Cloned NMDA receptor channels of the NR1‐NR2A, NR1‐NR2B and NR1‐NR2C type show differences in argiotoxin 636 block. Mutations of an asparagine residue located at a homologous position in the TM2 region of all NMDA receptor subunits, which corresponds to the Q/R site of the AMPA receptors, alters the argiotoxin 636 ‐induced block. The results suggest that the toxin interacts at this amino acid position with the putative pore forming TM2 region of the NMDA receptor subunits. Sequence differences in the TM2 segment of NR2A and NR2C subunits are not responsible for the subtype‐specific sensitivity to argiotoxin 636 as revealed by site‐directed mutagenesis.
Type of Medium:
Online Resource
ISSN:
0014-5793
,
1873-3468
DOI:
10.1016/0014-5793(93)81533-6
Language:
English
Publisher:
Wiley
Publication Date:
1993
detail.hit.zdb_id:
1460391-3
SSG:
12
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