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  • 1
    Online Resource
    Online Resource
    Fetal Growth Restriction: Comparison of Biometric Parameters
    MDPI AG ; 2022
    In:  Journal of Personalized Medicine Vol. 12, No. 7 ( 2022-07-11), p. 1125-
    Details
    In: Journal of Personalized Medicine, MDPI AG, Vol. 12, No. 7 ( 2022-07-11), p. 1125-
    Abstract: The aim of this study was to identify growth-restricted fetuses using biometric parameters and to assess the validity and clinical value of individual ultrasound parameters and ratios, such as transcerebellar diameter/abdominal circumference (TCD/AC), head circumference/abdominal circumference (HC/AC), and femur length/abdominal circumference (FL/AC). In a retrospective single-center cross-sectional study, the biometric data of 9292 pregnancies between the 15th and 42nd weeks of gestation were acquired. Statistical analysis included descriptive data, quantile regression estimating the 10th and 90th percentiles, and multivariable analysis. We obtained clinically noticeable results in predicting small-for-gestational-age (SGA) and fetal growth restriction (FGR) fetuses at advanced weeks of gestation using the AC with a Youden index of 0.81 and 0.96, respectively. The other individual parameters and quotients were less suited to identifying cases of SGA and FGR. The multivariable analysis demonstrated the best results for identifying SGA and FGR fetuses with an area under the curve of 0.95 and 0.96, respectively. The individual ultrasound parameters were better suited to identifying SGA and FGR than the ratios. Amongst these, the AC was the most promising individual parameter, especially at advanced weeks of gestation. However, the highest accuracy was achieved with a multivariable model.
    Type of Medium: Online Resource
    ISSN: 2075-4426
    URL: Article
    DOI: 10.3390/jpm12071125
    Language: English
    Publisher: MDPI AG
    Publication Date: 2022
    detail.hit.zdb_id: 2662248-8
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  • 2
    Online Resource
    Online Resource
    Update Reference Charts: Fetal Biometry between the 15th and 20th Week of Gestation
    S. Karger AG ; 2016
    In:  Fetal Diagnosis and Therapy Vol. 40, No. 3 ( 2016), p. 195-204
    Details
    In: Fetal Diagnosis and Therapy, S. Karger AG, Vol. 40, No. 3 ( 2016), p. 195-204
    Abstract: 〈 b 〉 〈 i 〉 Objective: 〈 /i 〉 〈 /b 〉 The aim of this study was to derive reference charts between the 15th and 20th week of gestation for biparietal diameter (BPD), occipito-frontal diameter (OFD), head circumference (HC), abdominal circumference (AC) and femur length (FL) compared to commonly used curves and to evaluate the impact of maternal body mass index (BMI), ultrasound equipment, fetal gender and nicotine abuse. 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 In a cross-sectional study of 4,265 low-risk pregnancies, biometric data were obtained between the 15th and 20th week of gestation. The statistical analysis included descriptive data, fitting regression curves for the 5th, 50th and 95th quantile as well as multivariate quantile regression analyses. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 Reference curves for BPD, OFD, HC, AC and FL showed a linear increase between the 15th and 20th week of gestation. New equations and reference charts are presented in this study. In a comparison of influence factors sex, BMI and ultrasound systems have an impact. 〈 b 〉 〈 i 〉 Conclusion: 〈 /i 〉 〈 /b 〉 As a result of the study, we determined current growth curves for BPD, OFD, HC, AC and FL for both sexes as well as for males and females separately. The updated growth curves for all biometric parameters differ from the curves used commonly in the last two decades.
    Type of Medium: Online Resource
    ISSN: 1015-3837 , 1421-9964
    URL: Article
    DOI: 10.1159/000443880
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2016
    detail.hit.zdb_id: 1482292-1
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  • 3
    Online Resource
    Online Resource
    Update Reference Charts: Fetal Biometry between the 15th and 42nd Week of Gestation
    Georg Thieme Verlag KG ; 2022
    In:  Zeitschrift für Geburtshilfe und Neonatologie Vol. 226, No. 06 ( 2022-12), p. 367-376
    Details
    In: Zeitschrift für Geburtshilfe und Neonatologie, Georg Thieme Verlag KG, Vol. 226, No. 06 ( 2022-12), p. 367-376
    Abstract: Objectives This study was designed to establish new reference charts for BPD (biparietal diameter), OFD (occipitofrontal diameter), HC (head circumference), CM (cisterna magna), TCD (transverse cerebellar diameter), PCV (posterior cerebral ventricle), AC (abdominal circumference), FL (femur length), and HL (humerus length) and extend known charts to 42 weeks of gestation. These new charts were compared to studies carried out by Snijders and Nicolaides, the INTERGROWTH 21st Project, and the WHO Fetal Growth Charts. Methods In this retrospective cross-sectional single-center study of 12,972 low-risk pregnancies, biometric data between the 15th and 42nd weeks of gestation were evaluated. Only one examination per pregnancy was selected for statistical analysis. Descriptive analysis for the 5th, 50th, and 95th quantile was performed for each parameter as listed above. Regression models were used to fit the mean and the SD at each gestational age. Results Initially the reference curves for BPD, OFD, HC, AC, FL, and HL show a linear increase, which changes into a cubic increase towards the end of pregnancy. The results of this study show statistically noticeable differences from the percentile curves of the studies listed above. Conclusions The percentile curves in this study differ from the commonly used ones. The presented standard curves can be used as a reference in prenatal diagnostics.
    Type of Medium: Online Resource
    ISSN: 0948-2393 , 1439-1651
    URL: Article
    DOI: 10.1055/a-1933-6723
    Language: English
    Publisher: Georg Thieme Verlag KG
    Publication Date: 2022
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  • 4
    Online Resource
    Online Resource
    Central nervous system biometry in fetuses with and without congenital heart diseases
    Springer Science and Business Media LLC ; 2022
    In:  Archives of Gynecology and Obstetrics Vol. 306, No. 6 ( 2022-03-17), p. 1885-1890
    Details
    In: Archives of Gynecology and Obstetrics, Springer Science and Business Media LLC, Vol. 306, No. 6 ( 2022-03-17), p. 1885-1890
    Abstract: To compare the fetal brain structures assessed in routine sonographic scans during the second and third trimesters in fetuses with and without congenital heart disease (CHD). Methods This is a retrospective cross-sectional single-center study. We measured the head circumference (HC), the transversal diameter of the cerebellum (TCD) and the sizes of the cisterna magna (CM), the cavum septi pellucidi (CSP) and the posterior ventricles (PV) between 20 and 41 weeks of gestation. We compared 160 fetuses with CHD (case group) to 160 fetuses of normal pregnancies (control group). Every patient was matched with a control, considering the gestational age at which the ultrasound was performed. We divided the CHD group into 3 subgroups: retrograde flow in the aortic arch (group 1), right heart anomaly with the antegrade flow in the aortic arch (group 2) and other CHDs with the antegrade flow in the aortic arch (group 3). Results The mean width of the PV was larger in fetuses of groups 1 and 3 in comparison to the control group ( P   〈  0.001, P  = 0.022; respectively). We found that the APGAR score at 5 min ( P   〈  0.001, P   〈  0.001; respectively) and gestational age at delivery ( P  = 0.006, P  = 0.001; respectively) were inferior in groups 1 and 3 compared to controls. Conclusions Central nervous system biometry is altered in fetuses with CHD. PV is enlarged in CHD fetuses especially with decreased oxygen levels in the aortic arch.
    Type of Medium: Online Resource
    ISSN: 1432-0711
    URL: Article
    DOI: 10.1007/s00404-022-06484-6
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2022
    detail.hit.zdb_id: 1458450-5
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