In:
Organic & Biomolecular Chemistry, Royal Society of Chemistry (RSC), Vol. 21, No. 34 ( 2023), p. 6903-6913
Abstract:
An efficient one-pot synthesis of 1,2,5-trisubstituted-1,2-dihydro-3 H -pyrrole-3-thiones (up to 91% yield), representatives of essentially new heterocyclic systems, by the successive treatment of available propargylamines with acyl chlorides (PdCl 2 /CuI/Ph 3 P/Et 3 N, toluene, 40–45 °C, 3 h) and sodium sulfide (Na 2 S·9H 2 O, EtOH, 20–25 °C, 7 h) has been developed. The synthesis comprises the addition of sulfide anions to the formed aminoacetylenic ketones followed by dehydrative cyclization of the prototropically rearranged adducts.
Type of Medium:
Online Resource
ISSN:
1477-0520
,
1477-0539
Language:
English
Publisher:
Royal Society of Chemistry (RSC)
Publication Date:
2023
detail.hit.zdb_id:
2097583-1
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