In:
The Open Biochemistry Journal, Bentham Science Publishers Ltd., Vol. 13, No. 1 ( 2019-12-31), p. 88-98
Abstract:
Multiple Sclerosis (MS) is a chronic inflammatory autoimmune disease of the Central Nervous System (CNS). Genetic, epigenetic and environmental factors interact together, contributing to the complex pathogenesis of the disease. In the last decades, the role of hypovitaminosis D on MS risk was hypothesised. Several factors drive the regulation of vitamin D status, including genetics. The current review summarises the literature evidence on the association between vitamin D and MS, with a focus on the genetic polymorphisms in vitamin D-related genes. The variants of the genes codifying Vitamin D Receptor (VDR), Vitamin D Binding Protein (VDBP) and CYP enzymes have been investigated, but the findings are controversial. Only a few studies have addressed the role of DHCR7 polymorphisms in MS risk.
Type of Medium:
Online Resource
ISSN:
1874-091X
DOI:
10.2174/1874091X01913010088
Language:
English
Publisher:
Bentham Science Publishers Ltd.
Publication Date:
2019
detail.hit.zdb_id:
2396170-3
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