In:
Ophthalmic Research, S. Karger AG, Vol. 42, No. 2 ( 2009), p. 112-116
Abstract:
〈 i 〉 Aim: 〈 /i 〉 The present study was designed to evaluate the intraocular pressure (IOP)-lowering activity of topical application of the aqueous extract of 〈 i 〉 Aegle marmelos 〈 /i 〉 fruit in experimental animal models. 〈 i 〉 Materials and Methods: 〈 /i 〉 New Zealand white rabbits with normal and experimentally elevated IOP using water loading and steroid-induced models were included in this study. The IOP-lowering effect of 〈 i 〉 A. marmelos 〈 /i 〉 fruit extract in rabbits with experimentally elevated IOP was also compared with that of timolol 0.25%. 〈 i 〉 Results: 〈 /i 〉 In rabbits with normal IOP, the 〈 i 〉 A. marmelos 〈 /i 〉 fruit extract at a concentration of 1% showed the maximum IOP-lowering effect with 22.81% reduction from baseline IOP. The maximum IOP reduction achieved in water loading and steroid-induced models with the same concentration of 〈 i 〉 A. marmelos 〈 /i 〉 was 27.57 and 28.41% from baseline, respectively. The efficacy was comparable to that of timolol after 45 min of water loading in the water loading model, and during the first 2 h of treatment in the steroid-induced model. 〈 i 〉 Conclusion: 〈 /i 〉 〈 i 〉 A. marmelos 〈 /i 〉 fruit extract showed significant IOP-lowering activity in experimental animal models.
Type of Medium:
Online Resource
ISSN:
0030-3747
,
1423-0259
Language:
English
Publisher:
S. Karger AG
Publication Date:
2009
detail.hit.zdb_id:
1483177-6
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