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Lifestyle modification program, LIFE is LIGHT, in patients with type 2 diabetes mellitus and obesity: Results from a 48‐week, multicenter, non‐randomized, parallel‐group, open‐label study

Galstyan, Gagik R. ; Valeeva, Farida V. ; Motkova, Svetlana I. ; [et al.]

Wiley ; 2021

In: Obesity Science & Practice Vol. 7, No. 4 ( 2021-08), p. 368-378

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In: Obesity Science & Practice, Wiley, Vol. 7, No. 4 ( 2021-08), p. 368-378

Abstract: Obesity is a potential risk factor for development of type 2 diabetes mellitus (T2DM). To achieve long‐term weight reduction in patients with T2DM and obesity using comprehensive lifestyle management program (LMP). Materials and methods This 48‐week interventional, multicenter, parallel‐group, open‐label study included patients aged ≥18 years with T2DM and a body mass index (BMI) of 27–40 kg/m 2 . The primary objective was to demonstrate a clinically significant weight reduction (≥5%) from baseline in intensive lifestyle modification (ILM) and standard treatment (ST) groups. Results The ILM group ( N = 100) received recommendations for dietary and physical activity, and behavioral counseling. The ST group ( N = 30) was managed in accordance with routine T2DM clinical practice. The patients in ST group were older (60.6 ± 8.9 vs. 54.6 ± 10.2 years in ILM group); overall more than 60% were women. At Week 48, the mean reduction in body weight was 5.8% (95% confidence interval [CI]: −6.9, −4.6) and 1.2% (95% CI: −2.6, 0.2) ( p 〈 0.001) in the ILM and ST group, respectively. At Week 48, a weight loss of ≥5% was achieved by 50% of patients in the ILM group versus 13.3% in the ST group ( p = 0.002). The decreases in BMI, waist‐to‐hip ratio and glycated hemoglobin (HbA1c) was significantly greater in the ILM versus ST group with between‐group differences of −1.63 ( p ≤ 0.001), −0.03 ( р ≤ 0.001) and −0.69% ( p = 0.002), respectively. Conclusion A clinically significant weight reduction (≥5%) was demonstrated in patients with obesity and T2DM with use of a comprehensive LMP, along with improvements in BMI, waist‐to‐hip ratio, and HbA1c.

Type of Medium: Online Resource

ISSN: 2055-2238 , 2055-2238

URL: Issue

URL: Article

DOI: 10.1002/osp4.v7.4

DOI: 10.1002/osp4.502

Language: English

Publisher: Wiley

Publication Date: 2021

detail.hit.zdb_id: 2836381-4

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Fig. 4. Changes in the thinking style of the program (%).

Andreeva, Svetlana I. ; Rudina, Larisa M. ; Savelyeva, Larisa V. ; [et al.]

Endocrinology Research Centre ; 2018

In: Problems of Endocrinology Vol. 64, No. 2 ( 2018-05-15), p. 93-104

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In: Problems of Endocrinology, Endocrinology Research Centre, Vol. 64, No. 2 ( 2018-05-15), p. 93-104

Abstract: Background. Despite the emergence of new modern classes of antihyperglycemic medications, lifestyle modification of patient with type 2 diabetes mellitus (T2DM) is a necessary component of the therapeutic approach in this disease. Clinically significant weight reduction and its maintenance is extremely important, but elusive goal for most patients with T2DM in the real clinical practice. The use of specially developed programs with involvement of the different profiles specialists (endocrinologists, dieticians, psychologists, instructors or сlinical exercise physiologists) can greatly contribute to this task. Aims — to study individual psychological characteristics in overweight (obese) patients with T2DM and to evaluate the dynamic of these characteristics, anthropometric, clinical and metabolic parameters during the comprehensive lifestyle modification program. Material and methods. The lifestyle modification program was developed. The main structural components of this program were dietary intervention, dosed individualized exercise intervention, specific model of team psychotherapeutic work (health coaching), comprehensive group education and dynamic medical support of patients with the adaptation of drug therapy. Psychological characteristics of patients, clinical and metabolic parameters and the level of physical activity were assessed before inclusion, at 3 and 12 months of follow-up. Results. The study was completed by 55 people of 60 (5 people dropped out of the study because of various reasons). There were not undesirable phenomena, directly related to participation in the program. At the end of the study we noted the positive dynamics of psychological characteristics in patients: 15% of men and 22% of women became less inclined to self-blame and hyper-responsibility; the locus of control in a relationship to own capabilities of health management changed from external to internal in 30% of women and 41% of men. 65% of participants achieved clinically significant weight loss (most patients reduced MT by 10% or more) and retained this result during 1 year. Improvement of clinical and metabolic parameters was also noted. Conclusions. The multidisciplinary lifestyle modification program in overweight (obese) patients with T2DM, the most important part of which was team psychotherapeutic work, showed high effectiveness of both the reduction of MT and the improvement of clinical and metabolic parameters in the long-term period.

Type of Medium: Online Resource

ISSN: 2308-1430 , 0375-9660

URL: Issue

URL: Article

DOI: 10.14341/probl2018642

DOI: 10.14341/probl9420

DOI: 10.14341/probl9420-2152

DOI: 10.14341/probl9420-2676

DOI: 10.14341/probl9420-2677

DOI: 10.14341/probl9420-2678

DOI: 10.14341/probl9420-2679

Language: Unknown

Publisher: Endocrinology Research Centre

Publication Date: 2018

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SUPPLEMENT 2. Rating of perceived exertion. Borg scale

Motkova, Svetlana I. ; Savelyeva, Larisa V. ; Rudina, Larisa M. ; [et al.]

Endocrinology Research Centre ; 2019

In: Diabetes mellitus Vol. 22, No. 2 ( 2019-06-23), p. 115-126

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In: Diabetes mellitus, Endocrinology Research Centre, Vol. 22, No. 2 ( 2019-06-23), p. 115-126

Abstract: BACKGROUND: Type 2 diabetes mellitus (T2DM) is a disease with high medical and social impact due to its wide and ever-increasing prevalence, high hospitalization and mortality rates. Despite the whole range of therapeutic options, lifestyle intervention remains as important as ever since it underlies guidelines of T2DM management. AIMS: To evaluate the effect of intensive lifestyle management approach on body weight reduction and on long-term maintenance of the achieved results in patients with T2DM. MATERIALS AND METHODS: We performed multicenter, interventional, prospective, non-randomized 12 month study. One hundred thirty overweight (obese) patients with T2DM included in the study were divided into two groups: group of lifestyle intervention (n=100) and control group (n=30). Patients in the group of lifestyle intervention participated in the intensive lifestyle modification and body weight reduction programme, which consisted of components: change in diet plan, physical exercise programme, cognitive behavioral techniques, educational and medical support. Clinical assessment and completing of patient questionnaires were performed at baseline, after 3 and 12 months. Patients in the control group did not attend programme, their clinical data were recorded during clinical visits every 3 months. RESULTS: Ninety patients (90%) in the group of lifestyle intervention and twenty nine patients (96.7%) in the control group completed the study and fulfilled protocol. After 12 months, patients in the group of lifestyle intervention lost 5.8% of their baseline weight and patients in the control group showed 1.2% decrease of their baseline weight. Body weight loss 5% was observed in 49.2% of patients in the group of lifestyle intervention and in 12.9% of patients in the control group (OR=6.54 [2.01; 21.33]; р=0.002). By the end of observation, delta reduction of glycated hemoglobin (HbA1c) in the intervention group was higher than in the control group (0.79% and 0.11%, respectively), the odds ratio for lowering HbA1c 0.5% from baseline between two groups was 14.10 [3.24; 61.30] (p0.001) in favor of the group of lifestyle intervention. 58.3% patients in the group of lifestyle intervention with baseline level of HbA1c 7% (n=48) achieved a HbA1c target of 7%; in the control group two patients (13.3%) out of fifteen with baseline level of HbA1c 7% achieved the target after 3 months and returned to baseline by the end of observation. CONCLUSIONS: Our results suggest that the programme of intensive lifestyle modification in patients with T2DM is highly efficient and safe.

Type of Medium: Online Resource

ISSN: 2072-0378 , 2072-0351

URL: Article

DOI: 10.14341/DM10001

DOI: 10.14341/DM10001-3462

DOI: 10.14341/DM10001-4036

DOI: 10.14341/DM10001-4038

DOI: 10.14341/DM10001-4133

DOI: 10.14341/DM10001-4134

DOI: 10.14341/DM10001-4135

DOI: 10.14341/DM10001-4136

DOI: 10.14341/DM10001-4137

DOI: 10.14341/DM10001-4037

DOI: 10.14341/DM10001-4039

Language: Unknown

Publisher: Endocrinology Research Centre

Publication Date: 2019

detail.hit.zdb_id: 2820710-5

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Сопроводительное письмо

Sozaeva, Leila S. ; Zilberman, Lubov I. ; Svetlova, Galina N. ; [et al.]

Endocrinology Research Centre ; 2018

In: Diabetes mellitus Vol. 21, No. 1 ( 2018-03-27), p. 48-57

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In: Diabetes mellitus, Endocrinology Research Centre, Vol. 21, No. 1 ( 2018-03-27), p. 48-57

Abstract: Background. Autoimmune polyglandular syndrome type 1 (APS type 1) is a rare inherited autoimmune disease caused by mutations in AIRE gene (autoimmune regulator) and characterized by list of components. Diabetes mellitus (DM) can be one of components of this disease. Aims. To show frequency of DM in patients with APS type 1 in Russia, to describe clinical and immunological aspects of DM in patients with APS type 1 Materials and methods. 113 patients have been enrolled in the study, 16 of them had DM (15/16) or impaired glucose tolerance (1/16). Antibodies against glutamate decarboxylase, tyrosine phosphatase, zinc transporter-8, insulin and -cells of pancreas were investigated in 30 patients with APS type 1 without DM and in 11 patients with APS type 1 and DM. ELISA test was used for detection autoantibodies. Results. Frequency of DM in patients with APS type 1 in Russia is 14.1% (16/113). Some patients had slow-progressive DM 19%(3/16). Antibodies against insulin and -cells were not specific and also were not sensitive markers for DM in APS type 1. Antibodies against tyrosine phosphatase and zinc transporter-8 test showed high specificity (100% и 97%), but low sensitivity (42% и 33,3%). Antibodies against glutamate decarboxylase were less specific (70%) and had very low sensitivity (58,3%). Conclusions. Frequency of DM in patients with APS type 1 in Russia is high to compare to other countries. 20% of Russian patients had slow-progressive course of DM. Antibodies against tyrosine phosphatase and zinc transporter-8 were the most specific for DM in patients with APS type 1, but sensitivity of these antibodies was low.

Type of Medium: Online Resource

ISSN: 2072-0378 , 2072-0351

URL: Article

DOI: 10.14341/DM9347

DOI: 10.14341/DM9347-1916

Language: Unknown

Publisher: Endocrinology Research Centre

Publication Date: 2018

detail.hit.zdb_id: 2820710-5

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