In:
Human Psychopharmacology: Clinical and Experimental, Wiley, Vol. 28, No. 1 ( 2013-01), p. 91-93
Abstract:
Antipsychotic drug action might include mechanisms related to normalising phospholipid and high‐energy metabolism. We applied brain metabolic imaging with 31 P magnetic resonance spectroscopy ( 31 P MRS) and two‐dimensional chemical shift imaging to assess changes of metabolism of phospholipids and high‐energy phosphates in schizophrenia patients at baseline (four antipsychotic‐naïve and three off antipsychotics) and at follow‐up, after 6 weeks of treatment with olanzapine. Results indicate a significant increase of adenosine‐triphosphate (ATP) in the right inferior temporal cortex and a trend towards ATP decrease in the left cerebellum. This suggests a shift in high‐energy phosphates (rather than phospholipids), possibly related to normalisation of functioning in these areas. Copyright © 2012 John Wiley & Sons, Ltd.
Type of Medium:
Online Resource
ISSN:
0885-6222
,
1099-1077
Language:
English
Publisher:
Wiley
Publication Date:
2013
detail.hit.zdb_id:
2001446-6
SSG:
15,3
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