In:
Natural Product Communications, SAGE Publications, Vol. 7, No. 11 ( 2012-11), p. 1934578X1200701-
Abstract:
Two new sesterterpenes, ophiobolin O (1) and 6-epi-ophiobolin O (2), together with the known ophiobolins G (3), H (4), and K (5), and 6-epi-ophiobolin K (6) were isolated from the marine derived fungus Aspergillus sp. The structures of these compounds were elucidated based on chemical and physicochemical evidence, including MS, UV, IR and NMR spectra. The stereochemistry of 1 was further confirmed by catalytic reaction of 5 with p-TsOH as a catalyst. Compounds 1 to 6 showed cytotoxicity against mouse leukemia cell line P388, with IC 50 values of 4.7, 9.3, 24.6, 105.7, 13.3 and 24.9 μM, respectively.
Type of Medium:
Online Resource
ISSN:
1934-578X
,
1555-9475
DOI:
10.1177/1934578X1200701102
Language:
English
Publisher:
SAGE Publications
Publication Date:
2012
detail.hit.zdb_id:
2430442-6
SSG:
15,3
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